GENDER-SPECIFIC ASSOCIATION OF VARIANTS IN THE<i>AKR1C1</i>GENE WITH DIMENSIONAL ANXIETY IN PATIENTS WITH PANIC DISORDER: ADDITIONAL EVIDENCE FOR THE IMPORTANCE OF NEUROSTEROIDS IN ANXIETY?

Quast, Carina; Reif, Andreas; Brückl, Tanja; Weber, Heike; Mattheisen, Manuel; Cichon, Sven; Lang, Thomas; Hamm, Alfons O.; Fehm, Lydia; Ströhle, Andreas; Arolt, Volker; Domschke, Katharina; Kircher, Tilo; Wittchen, Hans‐Ulrich; Pauli, Paul; Gerlach, Alexander L.; Alpers, Georg W.; Deckert, Jürgen; Rupprecht, Rainer; Binder, Elisabeth B.; Erhardt, Angelika

doi:10.1002/da.22229

Cited by 16 publications

(10 citation statements)

References 55 publications

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“…Unlike estrogen, there are not extensive data documenting the specific neural systems regulated by progesterone, so it is difficult to propose neurobiological pathways. However, promising data suggest that progesterone may play an important regulatory role in gene expression within several systems (e.g., serotonin, Gamma-Amino Butyric acid) that are thought to be important in anxiety and/or depression (Arbo, Andrade, Osterkamp, Gomez, & Ribeiro, 2014; Bethea & Centeno, 2008; Bethea & Reddy, 2015; Lu, Eshleman, Janowsky, & Bethea, 2003; Quast et al, 2014; Schüle, Nothdurfterb, & Rupprecht, 2014). It is likely that progesterone activates genetic effects via the same mechanisms as those proposed for estrogen during puberty (e.g., differential production of neurotransmitters and/or their receptors), although this possibility awaits investigation.…”

Section: Discussionmentioning

confidence: 99%

Differential Effects of Estrogen and Progesterone on Genetic and Environmental Risk for Emotional Eating in Women

Klump

O'Connor

Hildebrandt

et al. 2016

Clinical Psychological Science

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Recent data show shifts in genetic and environmental influences on emotional eating across the menstrual cycle, with significant shared environmental influences during pre-ovulation, and primarily genetic effects during post-ovulation. Factors driving differential effects are unknown, although increased estradiol during pre-ovulation and increased progesterone during post-ovulation are thought to play a role. We indirectly investigated this possibility by examining whether overall levels of estradiol and progesterone differentially impact genetic and environmental risk for emotional eating in adult female twins (N = 571) drawn from the MSU Twin Registry. Emotional eating, estradiol levels, and progesterone levels were assessed daily and then averaged to create aggregate measures for analysis. As predicted, shared environmental influences were significantly greater in twins with high estradiol levels, whereas additive genetic effects increased substantially across low versus high progesterone groups. Results highlight significant and differential effects of ovarian hormones on etiologic risk for emotional eating in adulthood.

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Section: Discussionmentioning

confidence: 99%

Differential Effects of Estrogen and Progesterone on Genetic and Environmental Risk for Emotional Eating in Women

Klump

O'Connor

Hildebrandt

et al. 2016

Clinical Psychological Science

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“…13,14 A recent genome-wide copy number variation study also found an excess of common duplications in a region on 16p11.2. 15 Genome-wide association (GWA) studies of PD [11][12][13][14][15][16][17][18][19][20][21] have not yet established risk loci, though 1 genetic 12,14,22,23 and functional 12,22 data have recently implicated variation in TMEM132D.…”

Section: Introductionmentioning

confidence: 99%

Candidate genes in panic disorder: meta-analyses of 23 common variants in major anxiogenic pathways

et al. 2015

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The utilization of molecular genetics approaches in examination of panic disorder (PD) has implicated several variants as potential susceptibility factors for panicogenesis. However, the identification of robust PD susceptibility genes has been complicated by phenotypic diversity, underpowered association studies and ancestry-specific effects. In the present study, we performed a succinct review of case-control association studies published prior to April 2015. Meta-analyses were performed for candidate gene variants examined in at least three studies using the Cochrane Mantel-Haenszel fixed-effect model. Secondary analyses were also performed to assess the influences of sex, agoraphobia co-morbidity and ancestry-specific effects on panicogenesis. Meta-analyses were performed on 23 variants in 20 PD candidate genes. Significant associations after correction for multiple testing were observed for three variants, TMEM132D rs7370927 (T allele: odds ratio (OR)=1.27, 95% confidence interval (CI): 1.15-1.40, P=2.49 × 10(-6)), rs11060369 (CC genotype: OR=0.65, 95% CI: 0.53-0.79, P=1.81 × 10(-5)) and COMT rs4680 (Val (G) allele: OR=1.27, 95% CI: 1.14-1.42, P=2.49 × 10(-5)) in studies with samples of European ancestry. Nominal associations that did not survive correction for multiple testing were observed for NPSR1 rs324891 (T allele: OR=1.22, 95% CI: 1.07-1.38, P=0.002), TPH1 rs1800532 (AA genotype: OR=1.46, 95% CI: 1.14-1.89, P=0.003) and HTR2A rs6313 (T allele: OR=1.19, 95% CI: 1.07-1.33, P=0.002) in studies with samples of European ancestry and for MAOA-uVNTR in female PD (low-active alleles: OR=1.21, 95% CI: 1.07-1.38, P=0.004). No significant associations were observed in the secondary analyses considering sex, agoraphobia co-morbidity and studies with samples of Asian ancestry. Although these findings highlight a few associations, PD likely involves genetic variation in a multitude of biological pathways that is diverse among populations. Future studies must incorporate larger sample sizes and genome-wide approaches to further quantify the observed genetic variation among populations and subphenotypes of PD.

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“…Zwei der wichtigsten weiblichen Geschlechtshormone -Estradiol und Progesteron -übernehmen mit ihren Neurosteroiden wichtige modulierende Funktionen in serotonergen, dopaminergen und GA-BA-ergen Systemen (2)(3)(4)(5)(6)(7)(8). Eine Veränderung der peripheren Hormonkonzentrationen bzw.…”

Section: Discussionunclassified

“…Eine Veränderung der peripheren Hormonkonzentrationen bzw. der Relationen der Hormone untereinander, kann bei entsprechend disponierten Frauen zu einer Dysfunktionalität in den jeweiligen Transmittersystemen führen (2)(3)(4)(5)(6)(7)(8). Wieso manche Frauen hier besonders sensitiv sind und andere nicht, ist nicht bekannt.…”

Section: Discussionunclassified

Depression bei Frauen

Krüger¹

2015

Nervenheilkunde

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ZusammenfassungFrauen leiden häufig im Zusammenhang mit reproduktiven Ereignissen, also vor der Menstruation, während und nach der Schwangerschaft und in den Wechseljahren an affektiven Erkrankungen. Dieses liegt an den komplexen Zusammenhängen zwischen weiblichen Geschlechtshormonen und Neurotransmittern, aber natürlich auch an den Einflüssen belastender oder sich verändernder Lebensumstände. Affektive Symptome können in diesen Zusammenhängen erstmals manifest werden, und in Symptomausprägung oder Schwere variieren. Wochenbetterkrankungen betreffen fast 20% aller Frauen und bergen das Risiko der Schädigung des Kindes durch Vernachlässigung, durch komorbide Zwangssymptome und im extremen Fall durch Infantizid. Die Ursachen der Wochenbettdepression, die sich meist sechs Wochen nach der Geburt manifestiert, sind nicht geklärt. Die Therapie umfasst psychopharmakologische und psychotherapeutische Interventionen, erstere in Abhängigkeit davon, ob die Patientin stillen kann oder möchte. Die Perimenopause ist im Leben einer Frau die Zeit mit dem höchsten Depressionsund Angsterkrankungsrisiko. Hier sind die Zusammenhänge zwischen hormonellen Veränderungen und der psychischen Symptomatik gut belegt. Behandlungsstrategien beinhalten demnach sowohl hormonelle als auch psychopharmakologische, in manchen Fällen auch psychotherapeutische Interventionen.

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GENDER-SPECIFIC ASSOCIATION OF VARIANTS IN THEAKR1C1GENE WITH DIMENSIONAL ANXIETY IN PATIENTS WITH PANIC DISORDER: ADDITIONAL EVIDENCE FOR THE IMPORTANCE OF NEUROSTEROIDS IN ANXIETY?

Cited by 16 publications

References 55 publications

Differential Effects of Estrogen and Progesterone on Genetic and Environmental Risk for Emotional Eating in Women

Differential Effects of Estrogen and Progesterone on Genetic and Environmental Risk for Emotional Eating in Women

Candidate genes in panic disorder: meta-analyses of 23 common variants in major anxiogenic pathways

Depression bei Frauen

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