Gender-specific associations of genetic variants with metabolic syndrome components in the Tunisian population

Elouej, Sahar; Rejeb, Imen; Attaoua, Redha; Nagara, Majdi; Sallem, O.K.; Kamoun, Inès; Chargui, Mariem; Jamoussi, H.; Turki, Z.; Abid, Abdelmajid; Slama, C. Ben; Bahri, Sonia; Romdhane, Habiba Ben; Abdelhak, Sonia; Kéfi, Rym; Grigorescu, Florin

doi:10.3109/07435800.2016.1141945

Cited by 22 publications

(19 citation statements)

References 38 publications

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“…No study was interested in measuring the association between rs4420638 polymorphism and obesity previously. No association was reported for the rs4420638 with MetS, T2D, and HBP; similar results were observed in a Tunisian population [27].…”

Section: Discussionsupporting

confidence: 75%

Association study of APOE gene polymorphisms with diabetes and the main cardiometabolic risk factors, in the Algerian population

Boulenouar

Benchekor

Djellouli

et al. 2019

Egypt J Med Hum Genet

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Background: Metabolic syndrome (MetS) represents a combination of at least three primary metabolic abnormalities among which obesity, hyperglycemia, dyslipidemia, and high blood pressure (HBP); once combined, they increase the cardiovascular risk significantly. APOE gene is considered as a genetic risk factor for cardiovascular diseases, and it has been linked to MetS or related disorders in several populations. Our study aimed to analyze, for the first time, the association of three APOE gene polymorphisms with MetS risk and its components in a general Algerian population sample, and to highlight the potential influence of these polymorphisms on individual susceptibility to MetS, diabetes, high blood pressure, and obesity, which has never been studied before in the Algerian population. Results: The rs439401 showed a significant association with hypertension. The T allele confers a high risk of hypertension with an odds ratio (OR) of 1.46 (95% CI [1.12-1.9], p = 0.006). The rs4420638 polymorphism was significantly associated with obesity in the general population. The G allele provides protection against obesity; the resulting OR is 0.48 (95% CI [0.29-0.81], p = 0.004). Conclusions: Although APOE variants were not associated with the risk of MetS, the APOE polymorphism alleles were associated with some of the metabolic parameters in Algerian subjects. The relation of APOE rs439401 alleles with high blood pressure seems indicative of a state of stress of the population.

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Section: Discussionsupporting

confidence: 75%

Association study of APOE gene polymorphisms with diabetes and the main cardiometabolic risk factors, in the Algerian population

Boulenouar

Benchekor

Djellouli

et al. 2019

Egypt J Med Hum Genet

View full text Add to dashboard Cite

show abstract

“…The G allele of rs4420638 seems to confer a protective effect against obesity (OR 0.48,, p = 0.004), no study was interested in measuring association between rs4420638 polymorphism and obesity previously. No association was reported for the rs4420638 with MetS, T2D and HBP similar results were observed in Tunisian population (Elouej et al, 2016).…”

Section: Discussionsupporting

confidence: 72%

Genetic variants on chromosome 19 (rs439401 and rs4420638) are associated with obesity and high blood pressure in the Algerian population

et al. 2019

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Metabolic syndrome (MetS) represents a combination of at least three primary metabolic abnormalities from among obesity, hyperglycemia, dyslipidemia, and high blood pressure, once combined, they increase significantly the cardiovascular risk. The APOE gene is considered as a genetic risk factor for cardiovascular diseases, it has been linked to MetS or its traits in several populations. Our study aimed to analyze the association of three APOE gene polymorphisms with MetS risk and its components in a general population sample, and to highlight the potential influence of these polymorphisms on individual susceptibility to MetS. We performed this work using a population-based, cross-sectional study of a representative sample of 787 individuals (378 men and 409 women, aged between 30 and 64 years) recruited in the city of Oran, Algeria (the ISOR Study); the subjects were genotyped for four polymorphisms, rs7412, rs429358, rs4420638 and rs439401, located in the APOE gene, using the KASPar technology. rs439401 showed a significant association with hypertension (HBP). The T allele confers a high risk of hypertension with an odds ratio (OR) of 1.46 (95 % CI [1.12–1.9], p = 0.006). rs4420638 was significantly associated with obesity in the general population. The G allele provides protection against obesity, the resulting OR is 0.48 (95 % CI [0.29–0.81], p = 0.004). Although APOE variants were not associated with the risk of MetS, the APOE polymorphism alleles were associated with some of the metabolic parameters in Algerian subjects. The relation of APOE rs439401 alleles with a HBP is likely to be indicative of a state of stress of the population.

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“…The result of GWAS also confirmed that changes around the KLF14 gene locus are closely related to HDL‐C levels, metabolic syndrome, and atherosclerosis . These studies have implicated a group of highly correlated SNPs including rs4731702 and rs972283 ~14 kb upstream of KLF14 .…”

Section: Klf14 and Cholesterol Metabolismmentioning

confidence: 59%

“…The result of GWAS also confirmed that changes around the KLF14 gene locus are closely related to HDL-C levels, metabolic syndrome, and atherosclerosis. 27,[31][32][33] These studies have implicated a group of highly correlated SNPs including rs4731702 and rs972283~14 kb upstream of KLF14. 27,31 Recently, researchers utilized chromatin state maps to annotate an interval, and identified a~1.6 kb enhancer~5 kb upstream of KLF14, which encompassed five T2D-associated variants and showed marked tissuespecificity.…”

Section: Klf14 and Cholesterol Metabolismmentioning

confidence: 99%

The role of KLF14 in multiple disease processes

2020

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Kruppel‐like factor 14 (KLF14) is a newly identified member of the KLF family. Expression of KLF14 is induced by TGF‐β in intrauterine and ectodermal tissue. Initial researches on KLF14 focused on its role in lipid and glucose metabolism. In recent years, however, the role of KLF14 in regulating cell signaling pathways, cell proliferation and differentiation has been explored. Moreover, the research has gradually extended into the field of tumorigenesis and immune regulation. This paper aims to briefly review the functions of KLF14 in physiologyical and pathological process.

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Gender-specific associations of genetic variants with metabolic syndrome components in the Tunisian population

Abstract: Our results reveal new candidate genes for MetS in the Tunisian population and suggest that the genetic basis of this syndrome is gender dependent. Further studies are necessary to understand why these associations differ between males and females.

Cited by 22 publications

References 38 publications

Association study of APOE gene polymorphisms with diabetes and the main cardiometabolic risk factors, in the Algerian population

Association study of APOE gene polymorphisms with diabetes and the main cardiometabolic risk factors, in the Algerian population

Genetic variants on chromosome 19 (rs439401 and rs4420638) are associated with obesity and high blood pressure in the Algerian population

The role of KLF14 in multiple disease processes

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