Gender-Specific Associations of Perceived Stress and Coping Strategies with C-Reactive Protein in Middle-Aged and Older Men and Women

Shimanoe, Chisato; Otsuka, Yasuko; Hara, Megumi; Nanri, Hinako; Nishida, Yuichiro; Nakamura, Kazuyo; Higaki, Yasuki; Imaizumi, Takeshi; Taguchi, Naoko; Sakamoto, Tatsuhiko; Horita, Mikako; Shinchi, Koichi; Tanaka, Keitaro

doi:10.1007/s12529-013-9341-y

Cited by 26 publications

(45 citation statements)

References 42 publications

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“…These findings are consistent with previous studies showing that blood-based biomarkers of inflammation and insulin resistance are related to positive affect/happiness (Matsunaga et al, 2011;Steptoe et al, 2008), well-being (Boehm & Kubzansky, 2012;Osama & Shehab Ael, 2015;Phillips & Perry, 2015;Steptoe et al, 2012), optimism (Ikeda et al, 2011;Roy et al, 2010), psychological resilience or 'hardiness' (Fields, Hoyt, Linnville, & Moore, 2015;Sandvik et al, 2013), and perceived stress (Aschbacher et al, 2013;BarbosaÀLeiker et al, 2014;Shimanoe et al, 2014). Although longitudinal research is needed, our findings suggest the possibility that resilience, optimism, happiness, and low perceived stress might serve as protective factors against insulin resistance and inflammation and their associated negative health outcomes in both schizophrenia and HCs.…”

Section: Discussionsupporting

confidence: 92%

Positive mental health in schizophrenia and healthy comparison groups: relationships with overall health and biomarkers

Edmonds

Martin

Palmer

et al. 2016

Aging & Mental Health

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Positive mental health in schizophrenia and healthy comparison groups: relationships with overall health and biomarkers. Objective: Positive psychological factors (PPFs) have been reported to have a significant impact on health in the general population. However, little is known about the relationship of these factors with mental and physical health in schizophrenia. Method: One hundred and thirty-five outpatients with schizophrenia and 127 healthy comparison subjects (HCs), aged 26-65 years, were evaluated with scales of resilience, optimism, happiness, and perceived stress. Measures of mental and physical health were also obtained. Regression analyses examined associations of a PPF composite with health variables. Results: Relative to the HCs, the schizophrenia group had lower levels of PPFs. However, there was considerable heterogeneity, with over one-third of schizophrenia participants having values within the 'normative' range. The PPF composite was positively related to mental and physical health variables and with biomarkers of inflammation and insulin resistance. The relationship between PPFs and mental health was particularly strong for individuals with schizophrenia. Conclusion: A sizable minority of adults with chronic schizophrenia have levels of resilience, optimism, happiness, and perceived stress similar to HCs. Psychosocial interventions to enhance PPFs should be tested in patients with serious mental illnesses, with the goal of improving their mental health (beyond controlling symptoms of psychosis) and their physical health.

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Section: Discussionsupporting

confidence: 92%

Positive mental health in schizophrenia and healthy comparison groups: relationships with overall health and biomarkers

Edmonds

Martin

Palmer

et al. 2016

Aging & Mental Health

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“…The last two categories were merged in the analysis because of the small number of incident colorectal cancer cases. The one-year test-retest reliability of this question was fair to good21 (weighted κ = 0.55)22, which is similar to that reported in the INTERHEART study (weighted κ = 0.53)23.…”

Section: Methodssupporting

confidence: 83%

“…Another measurement problem is the use of a single question to measure perceived stress in the present study. The single-item measure used in the present study showed fair to good test-retest reliability22 and satisfactory content, criterion, and construct validity35. However, compared with a multiple-item measure, a single-item measure is more influenced by random measurement error, which leads to a decrease in the power to detect a true effect36.…”

Section: Discussionmentioning

confidence: 59%

Perceived Stress and Colorectal Cancer Incidence: The Japan Collaborative Cohort Study

Kikuchi¹,

Nishiyama

Sawada

et al. 2017

Sci Rep

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Colorectal cancer is the third most common cancer worldwide, and many risk factors for colorectal cancer have been established. However, it remains uncertain whether psychological stress contributes to the onset of colorectal cancer. Therefore, we conducted a large-scale prospective cohort study to confirm the association between perceived stress and colorectal cancer incidence. We identified 680 cases of colon cancer and 330 cases of rectal cancer during a maximum of 21-year follow-up of 61,563 Japanese men and women. Cox regression analysis adjusted for potential confounders revealed a significant association of perceived stress with rectal cancer incidence but not with colon cancer incidence. This finding is partly consistent with that from only one previous study that addressed an association between perceived stress and the risk of colorectal cancer. However, studies on this topic are sparse and warrant further exploration.

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“…Five coping behaviors were extracted from a dispositional version of the General Coping Questionnaire or the Brief COPE, and were assessed using one question: “How do you cope with various problems and unfavorable events you experience in daily life?” Participants answered this question by indicating the frequency (from 4 response categories: “seldom,” “sometimes,” “often,” “very often”) at which they use each of the following coping strategies: (1) “I express my negative feelings and thoughts”, (2) “I consult with someone close and ask for encouragement”, (3) “I try to interpret the problem in a favorable way”, (4) “I try hard to solve the problem” and (5) “I let the problem take its own course.” These coping behaviors were defined as “emotional expression,” “emotional support seeking,” “positive reappraisal,” “problem solving” and “disengagement,” respectively. The weighted kappa based on the 1‐year reproducibility survey was 0.41 for emotional expression, 0.49 for emotional support seeking, 0.30 for positive reappraisal, 0.48 for problem solving and 0.31 for disengagement . Because each coping behavior was examined as an ordinal variable, not a continuous variable following the normal distribution, the levels of each coping behavior were dichotomized to be included as an outcome variable in a mixed linear model, under the assumptions of the liability threshold model .…”

Section: Methodsmentioning

confidence: 99%

“…Perceived stress in daily life was assessed by a single question: “How much stress did you feel during the last year?” Participants chose from 4 response categories: (1) “I felt much stress”, (2) “I felt moderate stress”, (3) “I felt little stress” and (4) “I felt no stress at all.” The perceived stress level was classified as “high” for categories 1 and 2, and “low” for categories 3 and 4. The weighted kappa statistic for this question was 0.55 in a 1‐year reproducibility survey on a random sample ( N = 431) of study participants …”

Section: Methodsmentioning

confidence: 99%

A genome‐wide association study of coping behaviors suggests FBXO45 is associated with emotional expression

Shimanoe

Hachiya

Hara

et al. 2018

Genes Brain and Behavior

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Individuals use coping behaviors to deal with unpleasant daily events. Such behaviors can moderate or mediate the pathway between psychosocial stress and health-related outcomes. However, few studies have examined the associations between coping behaviors and genetic variants. We conducted a genome-wide association study (GWAS) on coping behaviors in 14088 participants aged 35 to 69 years as part of the Japan Multi-Institutional Collaborative Cohort Study. Five coping behaviors (emotional expression, emotional support seeking, positive reappraisal, problem solving and disengagement) were measured and analyzed. A GWAS analysis was performed using a mixed linear model adjusted for study area, age and sex. Variants with suggestive significance in the discovery phase (N = 6403) were further examined in the replication phase (N = 7685). We then combined variant-level association evidence into gene-level evidence using a gene-based analysis. The results showed a significant genetic contribution to emotional expression and disengagement, with an estimation that the 19.5% and 6.6% variance in the liability-scale was explained by common variants. In the discovery phase, 12 variants met suggestive significance (P < 1 × 10 ) for association with the coping behaviors and perceived stress. However, none of these associations were confirmed in the replication stage. In gene-based analysis, FBXO45, a gene with regulatory roles in synapse maturation, was significantly associated with emotional expression after multiple corrections (P < 3.1 × 10 ). In conclusion, our results showed the existence of up to 20% genetic contribution to coping behaviors. Moreover, our gene-based analysis using GWAS data suggests that genetic variations in FBXO45 are associated with emotional expression.

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Gender-Specific Associations of Perceived Stress and Coping Strategies with C-Reactive Protein in Middle-Aged and Older Men and Women

Abstract: Both perceived stress and coping strategies may be associated with systemic inflammation in Japanese men, yet caution must be exercised before accepting the stress-inflammation-disease pathway.

Cited by 26 publications

References 42 publications

Positive mental health in schizophrenia and healthy comparison groups: relationships with overall health and biomarkers

Positive mental health in schizophrenia and healthy comparison groups: relationships with overall health and biomarkers

Perceived Stress and Colorectal Cancer Incidence: The Japan Collaborative Cohort Study

A genome‐wide association study of coping behaviors suggests FBXO45 is associated with emotional expression

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