Gender-specific associations of serum sex hormone-binding globulin with features of metabolic syndrome in children

Al-Daghri, Nasser M.; Khan, Nasiruddin; Sabico, Shaun; Al‐Attas, Omar S.; Alokail, Majed S.; Kumar, Sudhesh

doi:10.1186/s13098-016-0134-8

Cited by 8 publications

(4 citation statements)

References 39 publications

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“…Recent studies have shown that low SHBG levels are predictive of higher risk for developing hypertension [5], T2D [6], and MetS [7,8]. A cross-sectional study showed that SHBG is a sensitive predictor of MetS in Arab adolescents [9]. There are limited data available about the association between circulating serum SHBG levels and MetS in the Saudi male population.…”

Section: Introductionmentioning

confidence: 99%

Serum Sex Hormone Binding Globulin (SHBG) Relation with Different Components of Metabolic Syndrome in Men with Type 2 Diabetes

et al. 2017

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Sex hormone binding globulin (SHBG) is demonstrated to be decreased in subjects with metabolic syndrome (MetS). The aim of the present study was to investigate the association of SHBG in relation to MetS components among men with type 2 diabetes (T2D). This cross-sectional study was carried out among 429 Saudi T2D male patients aged >30 years. Metabolic syndrome was defined using International Diabetes Federation (IDF) criteria. Fasting blood glucose (FBG), HbA1c, albumin, and lipid parameter were measured. Gonadal hormones, namely total testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and SHBG were determined using ELISA. The SHBG levels of the MetS group was significantly lower than non-MetS group 47.25±31.03 nmol/l vs. 56.55±37.84 nmol/l; p=0.013. As the MetS score increases, SHBG and HDL levels decrease while weight, BMI, waist circumference, SBP, DBP, FBG, HbA1c, TC, and TG levels increase. SHBG correlated with age, BMI, TG, HDL, TT, free testosterone, and bio-available testosterone. This is the first study that provides detailed analyses of SHBG with MetS components in male diabetic subjects. The mean serum SHBG levels gradually declined with the addition of MetS components in T2D men. TT, free testosterone, and bio-available testosterone remained independently associated with SHBG by multivariable regression analysis.

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Section: Introductionmentioning

confidence: 99%

Serum Sex Hormone Binding Globulin (SHBG) Relation with Different Components of Metabolic Syndrome in Men with Type 2 Diabetes

et al. 2017

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“…There is a large body of scientific evidence confirming the role of sex hormones in the development of MetS. An inverse association between serum SHBG levels and the prevalence of MetS has been observed in children aged 12–16 years, with SHBG being a more sensitive marker of MetS in boys, but not in girls, indicating sexual dimorphism already at an early age [ 234 ]. At older ages, an association between lower SHBG levels and MetS is still observed in both males and females, while total and free testosterone levels are lower in males and higher in females with MetS [ 235 – 237 ].…”

Section: Metabolic Syndromementioning

confidence: 99%

Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases

et al. 2023

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Metabolic diseases, such as obesity, metabolic syndrome (MetS) and type 2 diabetes (T2D), are now a widespread pandemic in the developed world. These pathologies show sex differences in their development and prevalence, and sex steroids, mainly estrogen and testosterone, are thought to play a prominent role in this sexual dimorphism. The influence of sex hormones on these pathologies is not only reflected in differences between men and women, but also between women themselves, depending on the hormonal changes associated with the menopause. The observed sex differences in gut microbiota composition have led to multiple studies highlighting the interaction between steroid hormones and the gut microbiota and its influence on metabolic diseases, ultimately pointing to a new therapy for these diseases based on the manipulation of the gut microbiota. This review aims to shed light on the role of sexual hormones in sex differences in the development and prevalence of metabolic diseases, focusing on obesity, MetS and T2D. We focus also the interaction between sex hormones and the gut microbiota, and in particular the role of microbiota in aspects such as gut barrier integrity, inflammatory status, and the gut–brain axis, given the relevance of these factors in the development of metabolic diseases.

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“…found that lower SHBG was more significantly related to developing metabolic diseases than lower TT in community-dwelling men older than 70 years in Perth, Western Australia ( 21 ). And another cross-sectional research found that SHBG was a highly sensitive predictor of MetS in Arab adolescents ( 22 ). However, few studies have examined the relationship between serum SHBG levels and MetS in populations of Chinese men.…”

Section: Introductionmentioning

confidence: 99%

Gonadal hormones and metabolic syndrome in middle-aged and elderly males: results from a prospective cohort study in China

Zhang,

Chen,

et al. 2024

Front. Endocrinol.

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BackgroundResearch has shown that gonadal hormones are involved in metabolic pathways relevant to metabolic syndrome (MetS). Nevertheless, no longitudinal study has been conducted on the association between SHBG and MetS in Chinese. The objective of our study was to determine whether there is any association between middle-aged and elderly males in China.MethodsA total of 531 eligible male subjects, aged above 40 years or older, without MetS at baseline, were recruited. Sex hormone binding globulin (SHBG), total testosterone (TT), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were measured. A harmonized definition and recommended thresholds for the Chinese population were used to determine metabolic syndrome.ResultsDuring 3.2 years of follow-up, 20.7% of subjects had developed MetS. Compared with the non-MetS group, subjects in the new-onset MetS group had significantly lower SHBG (43.5 nmol/L [28.8, 74.9] vs 53.7nmol/L [33.8, 115.0], P=0.0018), TT (18.1nmol/L [13.6–21.7] vs 19.5nmol/L[15.0–23.6], P=0.0204), and LH (5.13mIU/L [3.63–7.29] vs 5.87mIU/L [4.05–8.36]) at baseline. The incidence of MetS was decreased according to elevated SHBG quartiles (Q1:26.9%, Q2:22.7%, Q3:21.1%, Q4:12.1%, P for trend =0.0035), TT (Q1: 25.2%, Q2:23.7%, Q3: 17.3%, Q4: 16.7%, P for trend=0.0425), and LH (Q1:25.0%, Q2:21.8%, Q3: 21.8%, Q4: 14.3%, P for trend=0.0411). Compared with those in quartile 4, the OR[CI] of incident MetS for participants in Quartile 1 was 2.33[1.13–4.79] after multiple adjustments. But associations between incident MetS and different quartiles of LH, TT, and FSH were not observed after multiple adjustments. In the subgroup analyses, the significant association between SHBG level and Mets was detected in subjects over 60 years or older, with normal BMI, without insulin resistance, and with eGFR ≥90 mL/min per 1.73m2.ConclusionCompared with TT, LH, and FSH, a lower level of SHBG is significantly related to the incidence of MetS among middle-aged and elderly males in China.

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Gender-specific associations of serum sex hormone-binding globulin with features of metabolic syndrome in children

Cited by 8 publications

References 39 publications

Serum Sex Hormone Binding Globulin (SHBG) Relation with Different Components of Metabolic Syndrome in Men with Type 2 Diabetes

Serum Sex Hormone Binding Globulin (SHBG) Relation with Different Components of Metabolic Syndrome in Men with Type 2 Diabetes

Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases

Gonadal hormones and metabolic syndrome in middle-aged and elderly males: results from a prospective cohort study in China

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