Gender-specific contribution of cardiometabolic index and lipid accumulation product to left ventricular geometry change in general population of rural China

Wang, Haoyu; Sun, Yingxian; Zhao, Li; Guo, Xiaofan; Chen, Shuang; Ye, Ning; Tian, Yichen; Zhang, Lijun

doi:10.1186/s12872-018-0798-0

Cited by 25 publications

(18 citation statements)

References 61 publications

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“…After excluding people with pregnancy, malignant tumor and mental disease, the survey recruited a total of 11,956 participants (age ≥ 35 years) between January 2013 and August 2013 at 26 rural villages across Liaoning province in China. Details regarding the design and rationale of NCRCHS has been fully displayed elsewhere [26–28]. In the present study, 3808 participants were further excluded due to their missing values of covariates.…”

Section: Methodsmentioning

confidence: 99%

“…Prior studies have delineated data collection and measurements in detail [26–28]. In brief, after cardiologists and nursed completed a training course and passed an exam, they were certificated for conducting questionnaires which collected data about demographic information, health-related behavior, anthropometric parameters and the use of lipid-lowering drug (at least one type versus no).…”

Section: Methodsmentioning

confidence: 99%

“…The subjects were reminded of keeping an overnight fasting with 12 h before the investigation. Details about the process of blood sample transportation, storage and laboratory tests were extensively described in our previous studies [26–28].…”

Section: Methodsmentioning

confidence: 99%

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Assessing the performance of monocyte to high-density lipoprotein ratio for predicting ischemic stroke: insights from a population-based Chinese cohort

Wang

Shi

Yi³

et al. 2019

Lipids Health Dis

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Background Monocyte to high-density lipoprotein cholesterol ratio (MHR) is a recently emerged measure of inflammation and oxidative stress and has been used to predict multiple cardiovascular abnormalities, but data relative to ischemic stroke are lacking. The goal of this study was to estimate the associations of MHR and prevalent ischemic stroke among a large cohort of general Chinese population. Method The study analyzed 8148 individuals (mean age: 54.1 years; 45.7% males) enrolled in a cross-sectional population-based Northeast China Rural Cardiovascular Health Study (NCRCHS). We identified 194 patients admitted from January and August 2013 with ischemic stroke. Results After adjustment for age, sex, and potential confounders, each standard deviation (SD) increment of MHR was predictive to a greater odd of ischemic stroke (odds ratio, 1.276; 95% confidence interval [CI], 1.082–1.504), with subjects in the highest quartile of MHR levels having a 1.6-fold higher risk of prevalent ischemic stroke (95% CI, 1.045–2.524) as compared with those in the lowest quartile. Moreover, smoothing curve showed a linear positive pattern of this association. The area under the curve (AUC) significantly increased ( P = 0.042) to 0.808 (95% CI, 0.779–0.837) when the combined MHR was added to the baseline logistic regression model with ischemic stroke risk factors. Also, MHR (0.004) significantly improved integrated discrimination improvement when added to the baseline model. Conclusions The present study demonstrated for the first time a linear relation between MHR levels and the odds of ischemic stroke in a large community-based population. The MHR, a marker of high atherosclerotic burden, demonstrated incremental predictive value over traditional clinical risk factors, thus providing clinical utility in risk stratification in subjects presenting with ischemic stroke. These findings had implications for strategies aimed at lowering MHR to prevent adverse cardiovascular and cerebrovascular outcomes.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Assessing the performance of monocyte to high-density lipoprotein ratio for predicting ischemic stroke: insights from a population-based Chinese cohort

Wang

Shi

Yi³

et al. 2019

Lipids Health Dis

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“…Thus, VAI could be a reliable marker in identifying VAT dysfunction and systemic metabolic disturbances including T2DM, hyperuricemia, and cardiovascular diseases [8,9,12,32]. Similarly, LAP, as an index for intra-abdominal fat accumulation, could predict insulin resistance-related metabolic disorders [14,33,34]. One prospective study reported LAP was independently associated with the risk of incident cardiovascular diseases among women at a median of 8.6-year follow-up [35].…”

Section: Discussionmentioning

confidence: 99%

Body Adiposity Index Is Predictive of Weight Loss after Roux-en-Y Gastric Bypass

Liu

Zhu

et al. 2021

Ann Nutr Metab

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Background/Aims: Roux-en-Y gastric bypass (RYGB) is one of the most effective therapies for morbid obesity, yet some patients who have taken the surgery still undergo insufficient weight loss. Visceral adiposity index (VAI), lipid accumulation product (LAP), body adiposity index (BAI), and cardiometabolic index (CMI) have been regarded as clinical indicators of adiposity phenotypes that associated closely with obesity-related metabolic diseases. However, no studies have evaluated the relationship between these indexes and weight loss after bariatric surgery. In this prospective study, we aimed to evaluate whether VAI, LAP, BAI, and CMI would predict postoperative weight loss outcomes after RYGB. Methods: This study included 38 men and 67 women who have undergone RYGB between January 2017 and May 2018 and recorded their %TWL (percent of total weight loss), %EBMIL (percent of excess body mass index loss), %EWL (percent of excess weight loss), anthropometric indices, and biochemical parameters before and 12 months after the surgery. In addition, VAI, LAP, BAI, and CMI were measured with anthropometric measures or lipid profiles using related equations and analyzed with metabolic characteristics. Results: Subjects with lower BAI (<32.54 in men and 37.39 in women) displayed higher %EBMIL and %EWL 12 months after surgery. BAI was independently associated with %EWL 12 months after surgery in both men and women (both p < 0.05). The area under the receiver operating characteristic curve for BAI was significantly higher (0.773 in men and 0.818 in women) than VAI, LAP, and CMI. Conclusions: BAI serves as a reliable surrogate marker of the weight loss outcome after RYGB. The predictivity of adiposity indexes in beneficial outcomes after weight loss therapies is of important referential value for the implementation and optimization of individualized and refined weight loss treatments for obese patients.

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“…Также данный индекс успешно применяется для идентификации лиц с высоким метаболическим риском при некоторых заболеваниях (псориазе, синдроме поликистозных яичников, гипосоматотропизме) [18,26,27]. Кроме того, обнаружена связь индекса LAP с атерогенностью липидного профиля крови и размерами липопротеинов [28], вязкостью крови [29], показателями давления [30,31], геометрией левого желудочка [32], концентрацией тиреотропного гормона [33], употреблением алкоголя [34,35], курением [36], уровнем физической активности [37,38], уровнем аланинаминотрансферазы [39], воспалительными биомаркерами и адипонектином [40], а также с показателями общей смертности [41].…”

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Lipid accumulation product or lap as an up-to-date clinical biochemical marker of human obesity

Kaneva¹,

Bojko²

2019

Health Risk Analysis

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Ожирение является важной медико-социальной проблемой, поскольку представляет серьезную угрозу для здоровья населения вследствие частого развития тяжелых сопутствующих заболеваний. Самым опасным видом ожирения считается висцеральное ожирение. Своевременная диагностика висцерального ожирения как на скрининговых осмотрах условно здорового населения, так и у лиц с сердечно-сосудистыми заболеваниями становится важным направлением как первичной, так и вторичной профилактики. В обзоре рассматривается современный маркер висцерального ожирения-индекс накопления липидов (lipid accumulation product-LAP). Этот индекс, предложенный H.S. Kahn в 2005 г., рассчитывается на основании двух переменных-обхвата талии (см) и уровня триглицеридов (ммоль/л), измеренного натощак. Одновременное использование биохимического и антропометрического показателей при расчете индекса LAP позволяет не только оценивать характер распределения жира в организме, но и отражать функциональное состояние жировой ткани. Индекс LAP широко используется в качестве маркера метаболических нарушений (метаболического синдрома, диабета, инсулинорезистентности, неалкогольной жировой болезни печени) и предиктора сердечно-сосудистых заболеваний. Кроме того, индекс LAP, обладая способностью идентифицировать фенотип ожирения, позволяет проводить градацию среди людей с избыточным весом на «метаболически здоровых» и «метаболически больных», а среди лиц с нормальным весом выявлять пациентов с метаболическим ожирением. Во многих исследованиях продемонстрировано, что индекс LAP обладает хорошим диагностическим и прогностическим потенциалом в отношении метаболических и сердечно-сосудистых заболеваний и является более точным маркером кардиометаболического риска, чем общепринятые антропометрические показатели. В обзоре представлены диапазоны варьирования, половые и возрастные особенности значений индекса LAP, а также характер и степень их изменения при ряде заболеваний. Освещены преимущества и недостатки применения индекса LAP на практике. Ключевые слова: индекс накопления липидов (LAP), обхват талии, триглицериды, индекс массы тела, ожирение, метаболический синдром, сердечно-сосудистые заболевания.

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Gender-specific contribution of cardiometabolic index and lipid accumulation product to left ventricular geometry change in general population of rural China

Cited by 25 publications

References 61 publications

Assessing the performance of monocyte to high-density lipoprotein ratio for predicting ischemic stroke: insights from a population-based Chinese cohort

Assessing the performance of monocyte to high-density lipoprotein ratio for predicting ischemic stroke: insights from a population-based Chinese cohort

Body Adiposity Index Is Predictive of Weight Loss after Roux-en-Y Gastric Bypass

Lipid accumulation product or lap as an up-to-date clinical biochemical marker of human obesity

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