Gender Specific Differences in a New Apoe-/-:Ins2+/Akita Mouse Model of Hyperglycemia-Induced Atherosclerosis

Venegas-Pino, Daniel E.; Hong, Bin; Pickersgill, Nicholas A.; Shi, Yan; Werstuck, Geoff H.

doi:10.1016/j.cjca.2014.07.587

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Hyperglycemia and Glucosamine-supplementstion Induce Similar1

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2015

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“…Consistent with previous findings, both hyperglycemia and glucosamine-supplementation significantly accelerated atherogenesis at the aortic sinus, relative to controls (Figure 2) [21][22][23]. Atherosclerotic lesion area was not significantly different between the three models of accelerated atherosclerosis.…”

Section: Hyperglycemia and Glucosamine-supplementstion Induce Similarsupporting

confidence: 91%

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Glucosamine-induced ER Stress Accelerates Atherogenesis: A Potential Link between Diabetes and Cardiovascular Disease

Dang¹,

Beriault²,

Deng³

et al. 2015

J Mol Genet Med

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Background: Cardiovascular disease is the leading cause of death worldwide and is responsible for three out of four deaths in diabetic individuals. Our lack of understanding of the molecular mechanisms linking diabetes and atherosclerosis impedes the development of effective treatment strategies. Hyperglycemia and glucosaminesupplementation have been shown to induce endoplasmic reticulum (ER) stress and activate the unfolded protein response (UPR) in murine models of atherosclerosis. We hypothesize that diabetes/hyperglycemia promotes atherosclerosis by a mechanism involving glucosamine-induced ER stress/UPR activation and that attenuation of ER stress, using the chemical chaperone 4-phenylbutyric acid (4PBA), will slow the accelerated development of atherosclerosis.

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Section: Hyperglycemia and Glucosamine-supplementstion Induce Similarsupporting

confidence: 91%

“…ApoE-/-mice were crossed with Ins2+/Akita mice to produce ApoE-/-:Ins2+/Akita offspring (n=4/group) [23]. Five-week-old female ApoE-/-mice were randomly divided into three groups (n=12/group): control, 5% glucosamine-supplemented and STZ-injected groups.…”

Section: Animal Modelsmentioning

confidence: 99%