Gender-specific expression of multiple estrogen receptors, growth hormone receptors, insulin-like growth factors and vitellogenins, and effects of 17β-estradiol in the male tilapia (Oreochromis mossambicus)

Davis, Lori K.; Pierce, Andrew L.; Hiramatsu, Naoshi; Sullivan, Craig V.; Hirano, Tetsuya; Grau, E. Gordon

doi:10.1016/j.ygcen.2008.03.002

Cited by 101 publications

(55 citation statements)

References 49 publications

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“…Intrapituitary regulators, including gonadotropin and inhibin/activin, provide autocrine/paracrine control over GH synthesis and secretion [96]. In rainbow trout, estrogen treatment significantly reduces food conversion, body growth, and the expression of GHRs, IGFs, and IGFRs [97]. At the somatotroph level, receptor expression of a multitude of neuroendocrine factors integrates the signals from various regulators [96].…”

Section: Other Neuropeptides and Neurotransmittersmentioning

confidence: 99%

Neuroendocrine regulation of somatic growth in fishes

Dai

Zhang

Zhuo

et al. 2015

Sci. China Life Sci.

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Growth is a polygenic trait that is under the influence of multiple physiological pathways regulating energy metabolism and muscle growth. Among the possible growth-regulating pathways in vertebrates, components of the somatotropic axis are thought to have the greatest influence. There is growing body of literature focusing on the somatotropic axis and its role regulating growth in fish. This includes research into growth hormone, upstream hypothalamic hormones, insulin-like growth factors, and downstream signaling molecules. Many of these signals have both somatic effects stimulating the growth of tissues and metabolic effects that play a role in nutrient metabolism. Signals of other endocrine axes exhibit profound effects on the function of the somatotropic axis in vivo. In this review we highlight recent advances in our understanding of the teleost fish endocrine somatotropic axis, including emerging research using genetic modified models. These studies have revealed new aspects and challenges associated with regulation of the important steps of somatic growth. somatic growth, endocrine regulation, fish Citation:

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Section: Other Neuropeptides and Neurotransmittersmentioning

confidence: 99%

Neuroendocrine regulation of somatic growth in fishes

Dai

Zhang

Zhuo

et al. 2015

Sci. China Life Sci.

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“…Specific primer pairs and probes used for qrtPCR of GH receptor (GHR), PRL receptor (PRLR), and SL receptor (SLR) are reported by Pierce et al (2007). IGF-I and -II qrtPCR is described by Davis et al (2008). For detection of glucocorticoid (cortisol) receptor (GR; GenBank accession no.…”

Section: Plasma Parametersmentioning

confidence: 99%

Gene expression of growth hormone family and glucocorticoid receptors, osmosensors, and ion transporters in the gill during seawater acclimation of Mozambique tilapia, Oreochromis mossambicus

et al. 2010

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This study characterized endocrine and ionoregulatory responses accompanying seawater (SW) acclimation in Mozambique tilapia (Oreochromis mossambicus). Changes in plasma hormones and gene expression of hormone receptors, putative osmosensors, and ion transporters in the gill were measured. Transfer of freshwater (FW)-acclimated tilapia to SW resulted in a marked elevation in plasma osmolality and a significant rise in plasma growth hormone (GH) levels at 12 hr and 14 days after transfer. Significant reductions in plasma prolactin (PRL(177) and PRL(188)) levels also occurred in SW-transferred fish; no effect of transfer upon plasma cortisol or insulin-like growth factor I was observed. Gene expression of GH receptor increased strongly 6 hr after transfer, whereas PRL receptor was lower than controls at 12 hr. By contrast, mRNA levels of somatolactin and glucocorticoid receptors were unaffected by SW transfer. Osmotic stress transcription factor 1 mRNA levels rose significantly between 3 and 12 hr, whereas the calcium-sensing receptor was unaffected. Aquaporin-3 gene expression was strongly down-regulated during SW acclimation from 12 hr until the conclusion of the experiment. Na(+)/K(+)/2Cl(-) cotransporter gene expression increased significantly 3 hr after transfer, whereas expression of Na(+)/Cl(-) cotransporter, specific to FW-type chloride cells, declined by 6 hr into SW acclimation. The response of Na(+)/H(+) exchanger was less pronounced, but showed a similar pattern to that of the Na(+)/Cl(-) cotransporter. These results suggest that acquisition of hyposmoregulatory mechanisms in Mozambique tilapia entails the coordinated interaction of systemic hormones with local factors in the gill, including hormone receptors, ion transporters, and osmosensors.

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“…Of interest, higher expression of the short OmPRLR2 variant in tilapia males than in females may indicated that prolactin signaling is gender specific and inhibited at the receptor level in males. Recently, gender-specific differences were also found in the expression of a variety of other tilapia receptors, including growth hormone receptor and several estrogen receptors (Davis et al, 2008).…”

Section: Two Variants Of Tilapia Prlr2 Are Expressedmentioning

confidence: 99%