2011
DOI: 10.4161/fly.5.3.15572
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Gender-specific prandial response to dietary restriction and oxidative stress inDrosophila melanogaster

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Cited by 12 publications
(9 citation statements)
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“…This effect is not limited to H 2 O 2 , as many supplements have been found to reduce feeding in flies [97], and this may extend to other oxidative stressors including paraquat and menadione. While several studies have detected reduced feeding in response to paraquat-containing food [102,103], others detected no difference [68]. Contrary to the latter study, our data suggest that feeding is significantly reduced in the three genotypes tested in assays that measured feeding over either 2h or 24h (Fig 1).…”
Section: Starvation As a Confounding Factor In Stress Assayscontrasting
confidence: 99%
“…This effect is not limited to H 2 O 2 , as many supplements have been found to reduce feeding in flies [97], and this may extend to other oxidative stressors including paraquat and menadione. While several studies have detected reduced feeding in response to paraquat-containing food [102,103], others detected no difference [68]. Contrary to the latter study, our data suggest that feeding is significantly reduced in the three genotypes tested in assays that measured feeding over either 2h or 24h (Fig 1).…”
Section: Starvation As a Confounding Factor In Stress Assayscontrasting
confidence: 99%
“…Thus, resveratrol uptake should not be much different among these three diets. On the other hand, we previously demonstrated that female flies on the DR and high-fat diets increased food intake in volume by about twofold, when compared to those on the standard base diet (Zeng et al 2011;Boyd et al 2011). Thus, flies ingested about twofold more resveratrol on the DR or high-fat diet, when compared to the base diet with the same concentration of resveratrol.…”
Section: Discussionmentioning
confidence: 83%
“…While label dynamics—including absorption, elimination, and metabolism—are a theoretical concern, previous studies have shown that accumulation of the radioactive tracer over 24 hours is nearly equivalent to the actual rate of ingestion (Carvalho et al 2006; Carvalho et al 2005; Ja et al 2009). Additionally, it has been shown on multiple diets that only ~5% of the consumed tracer is excreted within the 24-h feeding period (Zeng et al 2011). We show that tracer accumulation is reasonably linear over two days and relative differences in consumption between diets remain stable during this period (Supplementary Fig.…”
Section: Discussionmentioning
confidence: 99%