Gender-specific prevalence and risk factors of mild cognitive impairment among older adults in Chongming, Shanghai, China

Abstract

ObjectiveThis study explores the gender differences in the prevalence of mild cognitive impairment (MCI) and the correlation between multiple influencing factors.Materials and methodsThe sample was comprised of 1325 relatively healthy participants aged ≥ 60 years in a Shanghai community-dwelling (557 males and 768 females). Cognitive function was assessed by Mini-Mental State Examination (MMSE). The Instrumental Activities of Daily Living (IADL) scale was used to assess the activities of daily living.ResultsThe overall prevalence of MCI was 15.2%, with 10.2% in men and 18.9% in women. In older male subjects, those with higher the Geriatric Depression Scale (GDS) scores [odds ratio (OR) = 1.07, 95% confidence interval (CI) = 1.01–1.14] and hypertension (OR = 2.33, 95% CI = 1.15–4.73) had a higher risk of MCI. female subjects who were illiterate (OR = 2.95, 95% CI = 1.82–4.78), had a farming background (OR = 1.69, 95% CI = 1.05–2.72), and a history of stroke (OR = 1.96, 95% CI = 1.07–3.59) had a higher risk of MCI, but this was not true for males. However, Male subjects who never smoked were less likely to have MCI (OR = 0.22, 95% CI = 0.09–0.54). Additionally, the prevalence of MCI was lower in older women with high grip strength (OR = 0.96, 95% CI = 0.92–0.99) and hyperlipidemia (OR = 0.45, 95% CI = 0.22–0.96).ConclusionThe prevalence of MCI was higher in the population of elderly women compared to men. Moreover, it was found that members with MCI tended to having higher GDS scores, smoking, and hypertension; whereas a history of farming, illiteracy, stroke, grip strength, and hyperlipidemia were correlated with MCI in women.

Predictors of probable attention deficit hyperactivity disorder in elderly patients with mild cognitive impairment visiting a memory clinic

“…However, current research findings on gender differences in the prevalence and influencing factors of MCI remain inconsistent. Although some studies found no gender difference in the prevalence of MCI, 29–31 other studies found that the prevalence of MCI was higher in females than in males 32,33 . Furthermore, the rate of progression to AD in patients with MCI is higher in females than in males, 34,35 and females with MCI may be more likely to have pre‐dementia.…”

The Managing Cancer and Living Meaningfully (CALM) Intervention Alleviates Chemotherapy-Related Cognitive Impairment in Patients with Breast Cancer by Modulating Pan-Immune-Inflammation Values

“… 23 Abebe et al 24 assessed cognitive function in patients with BC. The MMSE has been widely applied in cognitive studies of Chinese patients 25 - 27 and its reliability and validity have been verified previously. 28 , 29 MMSE scores ≤26 were considered to indicate cognitive impairment, while scores of 27 to 30 were considered normal.…”

Association of Unhealthy Lifestyle and Genetic Risk Factors With Mild Cognitive Impairment in Chinese Older Adults

“…To our knowledge, no studies have focused on the association between lifestyle and genetic risk ( APOE and MTHFR ) in the development of MCI, and most have focused on single lifestyle factors or the APOE gene instead of combined factors . A cross-sectional study of Chinese adults aged 80 years or older showed that healthy lifestyle was associated with better cognitive function in older adults, regardless of APOE genotype .…”

“…There is a wealth of evidence that individuals who have healthy diets, get regular physical activity, limit alcohol consumption, and do not smoke can reduce their risk of MCI . Some studies have combined lifestyle factors into healthy lifestyle scores to investigate their association with other diseases, such as dementia and cardiovascular disease .…”