Gender specific short stature in male adolescents with obsessive-compulsive disorder

Hu, Yu-Pei; Wehrly, Rebecca; Gorrindo, Tristan; Hezel, Dianne M.; Gironda, Christina; Jenike, Michael A.; Stewart, S. Evelyn

doi:10.1016/j.jocrd.2012.07.009

Cited by 3 publications

(4 citation statements)

References 45 publications

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“…OCD is clinically and genetically associated with TS and is considered along with ADHD to constitute the “TS triad.” 1 Thus, it is notable that short stature has been reported to be common in adolescent males, but not females, with OCD. 12 Blunted nocturnal growth hormone secretion, decreased pituitary gland volume, and delayed onset of puberty have all been observed in OCD patients. 12 Abnormal serotonin neurotransmission in the brain has been suggested to occur in OCD, and some serotonin receptor subtypes (1D and 2C) play a role in the neuroendocrine regulation of growth hormone.…”

Section: Discussionmentioning

confidence: 99%

“… 12 Blunted nocturnal growth hormone secretion, decreased pituitary gland volume, and delayed onset of puberty have all been observed in OCD patients. 12 Abnormal serotonin neurotransmission in the brain has been suggested to occur in OCD, and some serotonin receptor subtypes (1D and 2C) play a role in the neuroendocrine regulation of growth hormone. 13 Because of the genetic link between OCD and TS, it is possible that these mechanisms may contribute to shorter stature in individuals with tic disorders.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Tics and Shorter Stature: Should We Be Looking for an Association?

Holleb¹,

Rabin²,

Kurlan³

2014

Tremor and Other Hyperkinetic Movements

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Tics and Shorter Stature: Should We Be Looking for an Association?

Holleb¹,

Rabin²,

Kurlan³

2014

Tremor and Other Hyperkinetic Movements

View full text Add to dashboard Cite

“…1 Thus, it is notable that short stature has been reported to be common in adolescent males, but not females, with OCD. 12 Blunted nocturnal growth hormone secretion, decreased pituitary gland volume, and delayed onset of puberty have all been observed in OCD patients. 12 Abnormal serotonin neurotransmission in the brain has been suggested to occur in OCD, and some serotonin receptor subtypes (1D and 2C) play a role in the neuroendocrine regulation of growth hormone.…”

Section: Discussionmentioning

confidence: 99%

“…12 Blunted nocturnal growth hormone secretion, decreased pituitary gland volume, and delayed onset of puberty have all been observed in OCD patients. 12 Abnormal serotonin neurotransmission in the brain has been suggested to occur in OCD, and some serotonin receptor subtypes (1D and 2C) play a role in the neuroendocrine regulation of growth hormone. 13 Because of the genetic link between OCD and TS, it is possible that It is believed that long-term treatment of ADHD with stimulant medications is associated with a small but significant reduction in growth, 14 and it has been suggested that the mechanism involves druginduced dopamine transporter blockade and resultant elevated dopamine levels in the hypothalamus.…”

Section: Discussionmentioning

confidence: 99%

Tics and Shorter Stature: Should We Be Looking for an Association?

Holleb¹,

Rabin²,

Kurlan³

2014

Tremor and Other Hyperkinetic Movements

View full text Add to dashboard Cite

Background: Tic disorders have commonly occurring and well recognized comorbidities including obsessive-compulsive disorder (OCD) and attention deficit hyperactivity disorder (ADHD). Shorter stature is not generally appreciated as an associated feature. Methods: Case reports and a literature review. Results: We describe four recently encountered patients with tics and shorter stature. The literature suggests that in addition to OCD and ADHD, shorter stature may also commonly accompany tic disorders. A variety of neuroendocrine mechanisms have been proposed. Discussion: The potential associations between shorter stature and tic disorders and the common comorbidities OCD and ADHD deserve more attention. More research is needed to establish the strength of these associations and the underlying neurobiological mechanisms.

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Fathers' “not just right experiences” predict obsessive–compulsive symptoms in their sons: Family study of a non-clinical Italian sample

Sica

Caudek

Bottesi

et al. 2013

Journal of Obsessive-Compulsive and Related Disorders

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The heart of the obsessional process may be considered the subject's underlying impression that -something is wrong‖. Therefore, the phenomenon labeled -not just right experiences‖ (NJREs) has increasingly been receiving attention since it captures the subjective sense that -something isn't just as it should be‖. In the present study we sought to add to the evidence that NJREs may be a putative psychological marker of OCD. To this aim, measures of NJREs, obsessive-compulsive (OC) symptoms and OC-related cognitions were completed by 382 undergraduates (43.2% females), 318 mothers and 288 fathers. NJREs correlations between parents and children were typically in the small-medium range of magnitude and comparable to correlations both for OC beliefs and symptoms. A series of hierarchical multiple regression analyses showed that fathers' (but not mothers') NJREs predicted OC symptomatology in their sons even when parents' anxiety symptoms and their level of OC-related beliefs were controlled. This relationship generally also held for single symptom dimensions such as washing, checking, ordering, and mental neutralizing symptoms. On the contrary, none of parents' psychological variables considered in the present study predicted OC symptoms in daughters. The possible role of NJREs as a marker of OCD is discussed.

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Gender specific short stature in male adolescents with obsessive-compulsive disorder

Cited by 3 publications

References 45 publications

Tics and Shorter Stature: Should We Be Looking for an Association?

Tics and Shorter Stature: Should We Be Looking for an Association?

Tics and Shorter Stature: Should We Be Looking for an Association?

Fathers' “not just right experiences” predict obsessive–compulsive symptoms in their sons: Family study of a non-clinical Italian sample

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