This study makes an effort to finds out the relationship of gender inequality towards macroeconomic variables in Pakistan using annual time series data 2000-2020. The dependent variable is GDP, whereas independent variables are working Force engagement Ratio of Male, working Force engagement Ratio of Female, Gender similarly Index, and Openness of Trade using ordinary least square Stata, Augmented Dickey-Fuller (ADF) unit root test is used. Research findings show that GDP is a dependent variable, which has a positive relationship with independent variables that can be more effectively achieved by adopting the suggested and concluded policies of this research work. In the light of this research article, there are some following suggestions to solve the problem of gender inequality in the education sector and job opportunities.