Gene- and Activation-specific Mechanisms for Insulin Inhibition of Basal and Glucocorticoid-induced Insulin-like Growth Factor Binding Protein-1 and Phosphoenolpyruvate Carboxykinase Transcription

Yeagley, David; Guo, Shaodong; Unterman, Terry G.; Quinn, Patrick G.

doi:10.1074/jbc.m101215200

Cited by 105 publications

(81 citation statements)

References 66 publications

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“…FKHR was first identified as a transcription factor involved in a translocation with PAX3 in alveolar rhab-domyosarcoma (10 -12). It also has an important role in apoptosis, glucose homeostasis, cell cycle regulation, and as a nuclear receptor cofactor (13)(14)(15)(16)(17)(18). We now report that FKHR is induced in decidualizing endometrium and participates in PKA signal transduction through its ability to interact and transcriptionally cooperate with C/EBP␤.…”

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confidence: 83%

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Cyclic AMP-induced Forkhead Transcription Factor, FKHR, Cooperates with CCAAT/Enhancer-binding Protein β in Differentiating Human Endometrial Stromal Cells

Christian¹,

Zhang²,

Schneider-Merck³

et al. 2002

Journal of Biological Chemistry

172

132

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During the menstrual cycle, ovarian estradiol and progesterone stimulate the ordered growth and differentiation of endometrial tissue compartments. In the human, this includes synchronous growth and coiling of the spiral arteries, secretory transformation of glandular epithelium, migration of bone marrow-derived cells, and decidualization of the stroma, which is thought to be essential for blastocyst implantation and subsequent formation of a hemochorial placenta. Decidualization of human endometrial stromal (ES)

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confidence: 83%

“…been reported (14,17). Selective expression vectors for the activating or inhibiting isoform of C/EBP␤, pSG/LAP, and pSG/LIP, respectively, have also been described previously (4).…”

Section: Camp-induced Fkhr Cooperates With C/ebp␤mentioning

confidence: 99%

Cyclic AMP-induced Forkhead Transcription Factor, FKHR, Cooperates with CCAAT/Enhancer-binding Protein β in Differentiating Human Endometrial Stromal Cells

Christian¹,

Zhang²,

Schneider-Merck³

et al. 2002

Journal of Biological Chemistry

172

132

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“…Such interactions may be particularly significant to the regulation of carbohydrate metabolism, where GCs and insulin have opposing actions. Glucose 6 phosphatase (Nakae et al, 2001) pyruvate dehydrogenase kinase 4 (Furuyama et al, 2003;Kwon et al, 2004), glucose 6 phosphate transporter (Kallwellis-Opara et al, 2003) and insulin-like growth factor binding protein 1 (Yeagley et al, 2001) are cooperatively regulated by GR and FoxO transcription factors. Insulin causes inactivation of FoxOs via Akt-mediated phosphorylation, thereby antagonizing GC-induced gene expression.…”

Section: A Clarkmentioning

confidence: 99%

Anti-inflammatory functions of glucocorticoid-induced genes

Clark

2007

Molecular and Cellular Endocrinology

238

193

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“…DAF-16 and its mammalian homologues, including FKHR (FOXO1), FKHRL1 (FOXO3a), and AFX (FOXO4) interact directly with IRSs from the IGFBP-1 promoter in a sequence-specific fashion in in vitro assays and in cells (1,5,9,19,20). In liver-derived cells, FOXO proteins stimulate the activity of promoters for IGFBP-1 (1), glucose-6 phosphatase (21,22), and PEPCK (23,24). In other cell types, FOXO proteins also stimulate the expression of proteins that inhibit cell cycle progression, including p27…”

mentioning

confidence: 99%

Phosphorylation of Serine 256 Suppresses Transactivation by FKHR (FOXO1) by Multiple Mechanisms

Zhang¹,

Gan²,

Pan³

et al. 2002

Journal of Biological Chemistry

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279

241

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FKHR is a member of the FOXO subfamily of Forkhead transcription factors, which are important targets for insulin and growth factor signaling. FKHR contains three predicted protein kinase B phosphorylation sites (Thr-24, Ser-256, and Ser-319) that are conserved in other FOXO proteins. We have reported that phosphorylation of Ser-256 is critical for the ability of insulin and insulin-like growth factors to suppress transactivation by FKHR (Guo, S., Rena, G., Cichy, S., He, X., Cohen, P., and Unterman, T. (1999) J. Biol. Chem. 274, 17184 -17192) and for its exclusion from the nucleus (Rena, G., Prescott, A. R., Guo, S., Cohen, P., and Unterman, T. G. Recent studies have revealed that FOXO Forkhead transcription factors are important targets for mediating effects of insulin and growth factors on gene expression downstream from phosphatidylinositol 3-kinase (PI3K) and protein kinase B (PKB; also known as Akt) (1-13). Early findings in this laboratory revealed that Forkhead transcription factors interact with insulin response sequences (IRSs) in the insulin-like growth factor-binding protein-1 (IGFBP-1) and phosphoenolpyruvate carboxykinase (PEPCK) genes (14, 15) and that signaling by PI3K and PKB mediate the ability of insulin to suppress basal IGFBP-1 promoter activity through an IRS (16). Subsequent studies in Caenorhabditis elegans provided genetic evidence that DAF-16, a member of the FOXO subfamily of Forkhead transcription factors, is a major target for signaling by the insulin/IGF receptor-PI3K-PKB pathway in the nematode (17, 18). DAF-16 and its mammalian homologues, including FKHR (FOXO1), FKHRL1 (FOXO3a), and AFX (FOXO4) interact directly with IRSs from the IGFBP-1 promoter in a sequence-specific fashion in in vitro assays and in cells (1,5,9,19,20). In liver-derived cells, FOXO proteins stimulate the activity of promoters for IGFBP-1 (1), glucose-6 phosphatase (21,22), and PEPCK (23,24). In other cell types, FOXO proteins also stimulate the expression of proteins that inhibit cell cycle progression, including p27 Kip (25), Rb2 (26), and GADD45 (27,28), and proteins that promote cells death, including Bim (29) and Fas ligand (5). Thus, the ability to suppress transactivation by FOXO Forkhead proteins is important for insulin to regulate hepatic production of IGFBP-1 and glucose and for effects of growth factors on cell proliferation and survival.Several critical features distinguish FOXO proteins from other Forkhead family members and make them uniquely suited as mediators of insulin and growth factor action. X-ray crystallographic studies with the DBD of HNF-3␥ indicated that the DNA binding motif of Forkhead proteins, named the Forkhead box, or FOX box, contains three ␣-helices, a wing-like

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Gene- and Activation-specific Mechanisms for Insulin Inhibition of Basal and Glucocorticoid-induced Insulin-like Growth Factor Binding Protein-1 and Phosphoenolpyruvate Carboxykinase Transcription

Cited by 105 publications

References 66 publications

Cyclic AMP-induced Forkhead Transcription Factor, FKHR, Cooperates with CCAAT/Enhancer-binding Protein β in Differentiating Human Endometrial Stromal Cells

Cyclic AMP-induced Forkhead Transcription Factor, FKHR, Cooperates with CCAAT/Enhancer-binding Protein β in Differentiating Human Endometrial Stromal Cells

Anti-inflammatory functions of glucocorticoid-induced genes

Phosphorylation of Serine 256 Suppresses Transactivation by FKHR (FOXO1) by Multiple Mechanisms

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