Gene and cell therapy for muscle regeneration

Stilhano, Roberta Sessa; Silva, Leonardo Martins; Ingham, Sheila Jean Mc Neill; Pesquero, João Bosco; Huard, Johnny

doi:10.1007/s12178-015-9268-9

Cited by 18 publications

(9 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gene therapy technologies similarly hold great promise for regeneration. [123] With such therapies, successful delivery is vital, making hydrogels an attractive platform to locally and sustainably deliver appropriate molecules. For example, Yang et al .…”

Section: Acellular Hydrogel Approachesmentioning

confidence: 99%

Exploiting Advanced Hydrogel Technologies to Address Key Challenges in Regenerative Medicine

Foyt

Norman

et al. 2018

Adv Healthcare Materials

118

View full text Add to dashboard Cite

Regenerative medicine aims to tackle a panoply of challenges from repairing focal damage to articular cartilage to preventing pathological tissue remodeling after myocardial infarction. Hydrogels are water‐swollen networks formed from synthetic or naturally derived polymers and are emerging as important tools to address these challenges. Recent advances in hydrogel chemistries are enabling researchers to create hydrogels that can act as 3D ex vivo tissue models, allowing them to explore fundamental questions in cell biology by replicating tissues' dynamic and nonlinear physical properties. Enabled by cutting edge techniques such as 3D bioprinting, cell‐laden hydrogels are also being developed with highly controlled tissue‐specific architectures, vasculature, and biological functions that together can direct tissue repair. Moreover, advanced in situ forming and acellular hydrogels are increasingly finding use as delivery vehicles for bioactive compounds and in mediating host cell response. Here, advances in the design and fabrication of hydrogels for regenerative medicine are reviewed. It is also addressed how controlled chemistries are allowing for precise engineering of spatial and time‐dependent properties in hydrogels with a look to how these materials will eventually translate to clinical applications.

show abstract

Section: Acellular Hydrogel Approachesmentioning

confidence: 99%

Exploiting Advanced Hydrogel Technologies to Address Key Challenges in Regenerative Medicine

Foyt

Norman

et al. 2018

Adv Healthcare Materials

118

View full text Add to dashboard Cite

show abstract

“…Muscle tissue contains progenitor populations that can be stimulated to form new muscle tissue. However, muscle regeneration is frequently limited by scar formation, rather than muscle regeneration [75].…”

Section: Muscle Repair and Regeneration Johnny Huard Phdmentioning

confidence: 99%

“…A combination of PRP injection and oral administration of losartan (an antifibrotic agent) has been shown to enhance muscle healing by stimulating muscle regeneration and angiogenesis and to prevent fibrosis in contusion-injured skeletal muscle [75]. Muscle regeneration and muscle function were significantly promoted with the combined PRP + losartan treatment in contusion injuries created in the tibialis anterior muscles of mice compared with the other groups.…”

Section: Muscle Repair and Regeneration Johnny Huard Phdmentioning

confidence: 99%

Proceedings of the signature series symposium “cellular therapies for orthopaedics and musculoskeletal disease proven and unproven therapies—promise, facts and fantasy,” international society for cellular therapies, montreal, canada, may 2, 2018

et al. 2018

Self Cite

View full text Add to dashboard Cite

“…Gene and cellular therapies, or the combination of both, appear as the main future therapies for muscle injury treatment. 126 Biomaterials have been used in muscle injuries for cell and growth factor delivery. 127 These biomaterials increase the survival and migration of the cells after transplantation in the injured muscle.…”

Section: Musclementioning

confidence: 99%

Biomaterial-Guided Gene Delivery for Musculoskeletal Tissue Repair

Madrigal

Stilhano

Silva

2017

Tissue Engineering Part B: Reviews

View full text Add to dashboard Cite

Gene therapy is a promising strategy for musculoskeletal tissue repair and regeneration where local and sustained expression of proteins and/or therapeutic nucleic acids can be achieved. However, the musculoskeletal tissues present unique engineering and biological challenges as recipients of genetic vectors. Targeting specific cell populations, regulating expression in vivo, and overcoming the harsh environment of damaged tissue accompany the general concerns of safety and efficacy common to all applications of gene therapy. In this review, we will first summarize these challenges and then discuss how biomaterial carriers for genetic vectors can address these issues. Second, we will review how limitations specific to given vectors further motivate the utility of biomaterial carriers. Finally, we will discuss how these concepts have been combined with tissue engineering strategies and approaches to improve the delivery of these vectors for musculoskeletal tissue regeneration.

show abstract

Gene and cell therapy for muscle regeneration

Cited by 18 publications

References 50 publications

Exploiting Advanced Hydrogel Technologies to Address Key Challenges in Regenerative Medicine

Exploiting Advanced Hydrogel Technologies to Address Key Challenges in Regenerative Medicine

Proceedings of the signature series symposium “cellular therapies for orthopaedics and musculoskeletal disease proven and unproven therapies—promise, facts and fantasy,” international society for cellular therapies, montreal, canada, may 2, 2018

Biomaterial-Guided Gene Delivery for Musculoskeletal Tissue Repair

Contact Info

Product

Resources

About