1996
DOI: 10.1099/13500872-142-11-3147
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Gene arrangement and organization in a   76 kb fragment encompassing the oriC region of the chromosome of Mycobacterium leprae

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Cited by 31 publications
(22 citation statements)
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“…Similarly located related genes, including spoIIIJ of B. subtilis, which is required for sporulation (10), are found in most bacteria (15). All of these genes encode proteins predicted to bind nucleoside triphosphate (14) and to contain several transmembrane domains, consistent with a membrane location. Downstream (by 15 nt) of orf431 is orf170, whose product of 170 amino acids has extensive homology to the jag gene product of B. subtilis and, particularly, its orthologues in mycobacteria.…”
Section: Resultsmentioning
confidence: 91%
See 1 more Smart Citation
“…Similarly located related genes, including spoIIIJ of B. subtilis, which is required for sporulation (10), are found in most bacteria (15). All of these genes encode proteins predicted to bind nucleoside triphosphate (14) and to contain several transmembrane domains, consistent with a membrane location. Downstream (by 15 nt) of orf431 is orf170, whose product of 170 amino acids has extensive homology to the jag gene product of B. subtilis and, particularly, its orthologues in mycobacteria.…”
Section: Resultsmentioning
confidence: 91%
“…Apparently translationally coupled to rnpA is orf124, homologues of which are found in the equivalent location in most bacterial chromosomes, though not in that of Mycobacterium leprae (14,15). The predicted S. coelicolor protein is larger (13.6 kDa) than the homologues in other bacteria (9 kDa) and contains no predicted transmembrane domains and is therefore probably cytoplasmic.…”
Section: Resultsmentioning
confidence: 98%
“…However, within the high GjC group of Gram-positive bacteria, Mycobacterium tuberculosis and S. coelicolor A3(2) each have more than five eukaryotic-type protein kinases. Mycobacterium leprae is also reported to have more than three kinases (Fsihi et al, 1996) ; Chlamydia trachomatis has two (Pkn5 and PknD), whereas spirochaetes (Borrelia burg- PkaB 0n82972 PkaG 1n39321 1n60986 AfsK 1n38722 1n66052 0n72440 PkaE 1n23367 1n24283 1n31829 1n45375 PkaF 1n21327 1n30989 1n44339 1n56899 1n19901 PkaD 1n43179 1n56128 1n51208 1n60317 1n53002 1n46337 Pks3 1n43914 1n51712 1n83070 1n73382 1n39806 1n54905 1n4363 1998 (Cole et al, 1998). On the other hand, HPO432, SLL0776 and PHCJ009 gave high scores for homology with several kinases : HPO432 with PknK, CTPknD and PH009 ; SLL0776 with PkaD, AfsK, PknE, CTPknD, SLR1225, SLR1443, SLR1697 and SLR0152 ; and PHCJ009 with PkaE, YloP, PknH, PknL, CTPkn5 and CTPknD (Table 3).…”
Section: Distribution Of Eukaryotic-type Protein Kinases In Bacteriamentioning
confidence: 99%
“…Recently, eukaryotic-type protein kinases have been detected in a small number of prokaryotes, including Streptomyces (Matsumoto et al, 1994 ;Urabe & Ogawara, 1995 ;Hirakata et al, 1998), Myxococcus (Munoz-Dorado et al, 1991 ;Zhang et al, 1992) and Mycobacterium (Fsihi et al, 1996 ;Cole et al, 1998). Since complete nucleotide sequences of the chromosomal DNA of over 10 bacterial species have now been determined (Doolittle, 1998), it would be interesting to know whether these contain eukaryotic-type protein kinases, and if so, how such kinases are distributed.…”
Section: Introductionmentioning
confidence: 99%
“…The protein product of the pcnA gene (Rv3907c ; Cole et al, 1998) of M. tuberculosis has 80 % similarity ( search) to the poly(A) polymerase-encoding gene pcnB of M. leprae (accession no. AAB53125 ; Fsihi et al, 1996), suggesting that this gene is conserved in mycobacteria. In addition, this protein has a high similarity to poly(A) polymerases from various organisms including Bacillus subtilis, E. coli and Helicobacter pylori, supporting our finding that polyadenylylation does occur in mycobacteria.…”
mentioning
confidence: 99%