Gene-Based Prescribing Is Here. Are Providers Ready?

Hull, Leland E.; Lehmann, Lisa Soleymani; Lynch, Julie

doi:10.1016/j.amjmed.2019.02.036

The American Journal of Medicine

2019

DOI: 10.1016/j.amjmed.2019.02.036

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Gene-Based Prescribing Is Here. Are Providers Ready?

Leland E. Hull

Lisa Soleymani Lehmann

Julie Lynch

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Cited by 4 publications

(2 citation statements)

References 7 publications

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“…In the last decades, patients have been more involved with their personal healthcare decisions. Their empowerment in the management of PGx data could improve the diffusion of test results among healthcare professionals and thus facilitate the implementation of PGx tests [25]. As PGx implementation will lie on a multidisciplinary framework, we postulated that the uptake of PGx in clinics will largely depend on PCPs', pharmacists' and patients' opinions and interests.…”

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confidence: 99%

Pharmacogenetic Testing in Primary Care Practice: Opinions of Physicians, Pharmacists and Patients

et al. 2019

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Aim: Although health authorities have set pharmacogenetic (PGx) markers on labels of hundreds of drugs, the use of PGx in clinical care remains infrequent. The adoption of PGx will depend on the opinions of physicians, pharmacists and patients. Materials & methods: Qualitative focus group interviews were performed with 23 physicians, 11 pharmacists and 30 patients. Results: Majority of the participants showed enthusiasm toward the implementation of PGx in clinics. Lack of knowledge on PGx, roles of healthcare providers, factors in favor and challenges of PGx implementation, ethical and insurance issues, educational and tools needs were the key themes that emerged from the interviews. Conclusion: Several barriers impede the uptake of PGx in clinics, however, opinions of physicians, pharmacists and patients are mostly favorable.

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confidence: 99%

Pharmacogenetic Testing in Primary Care Practice: Opinions of Physicians, Pharmacists and Patients

et al. 2019

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“…2 Furthermore, the effects of different geneedrug interactions are widely variable; while some geneedrug interactions may help a provider to titrate a drug to its ideal dose, other geneedrug interactions may be associated with severe and even life-threatening adverse drug reactions. 3 In some instances, an enzyme may be induced or inhibited by another drug, leading to an expression completely different from expected.…”

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confidence: 99%

Identifying End Users' Preferences about Structuring Pharmacogenetic Test Orders in an Electronic Health Record System

Hull

Vassy

Stone

et al. 2020

The Journal of Molecular Diagnostics

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Pharmacogenetics (PGx) testing can be used for detecting genetic variations that may affect an individual's anticipated metabolism of, or response to, medications. Although several studies have focused on developing tools for delivering results from PGx testing, there is a relative dearth of information about how to design provider-friendly electronic order-entry systems for PGx. The U.S. Department of Veterans Affairs (VA) is preparing to implement a new electronic health records system. In this study, VA PGx test end users were surveyed about their preferences for how electronic test orders for PGx should be structured, including the nomenclature that should be used to search for and identify PGx-test orders, whether to offer single-versus multigene tests, and whether information about test methodology should be included in the order name. Responses were analyzed systematically to identify areas of agreement and disagreement with the survey options, and areas where respondents' opinions diverged. End users endorsed preferences for flexible ways to identify and order PGx tests and multigene panel tests; opinions on whether test methodology should be included in the test name were divergent. The results could be used for both informing the VA's new electronic health records implementation (including how PGx tests are searched for and ordered) and for providing insights for other health systems implementing PGxtesting programs.

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Precision health: Determining the capacity of practicing nurses across the United States

Fangonil‐Gagalang,

Schultz,

Huryk

et al. 2024

J of Nursing Scholarship

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IntroductionPrecision Health (PH) holds the promise of revolutionizing healthcare by enabling personalized disease prevention and management through the integration of genomic data, lifestyle factors, environmental influences, and other social determinants of health (SDoH). However, the absence of a baseline assessment of knowledge, skills, and attitudes (KSAs) of practicing nurses' capacity for PH hinders its integration. The purpose of this study is to determine the capacity of practicing Registered Nurses (RNs) for PH across the United States and to assess the validity and reliability of a tool designed for this use—the Precision Health Nurse Capacity Scale (PHNCS).Design/MethodA descriptive exploratory study was conducted to evaluate the capacity of practicing RNs for this evolving phenomenon, PH, using a convenience sample. The survey was sent via email and made available to all members of the American Nurses Association (ANA) who work in a variety of practice environments. The ANA represents the over 4 million nurses practicing in the United States.ResultsThe majority of nurse respondents felt it is important for nurses to become more educated about all aspects of PH including SDoH but they lack confidence in the integration of PH. The PHNCS was found to be a valid and reliable tool in measuring the capacity of nurses to practice PH.ConclusionThe incorporation of PH into nursing practice suffers an immediate impediment: the lack of know‐how of the US nursing workforce. This inaugural data on KSAs for PH establishes a logical baseline from which the requisite education and training should commence.Clinical relevancePrecision Health is an emerging healthcare approach in the United States and globally. Enabling it will require a nursing workforce prepared with the requisite KSAs. Determining the capacity of the nursing workforce is a foundational step to begin this process.

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Gene-Based Prescribing Is Here. Are Providers Ready?

Cited by 4 publications

References 7 publications

Pharmacogenetic Testing in Primary Care Practice: Opinions of Physicians, Pharmacists and Patients

Pharmacogenetic Testing in Primary Care Practice: Opinions of Physicians, Pharmacists and Patients

Identifying End Users' Preferences about Structuring Pharmacogenetic Test Orders in an Electronic Health Record System

Precision health: Determining the capacity of practicing nurses across the United States

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