Gene biomarkers in peripheral white blood cells of horses with experimentally induced osteoarthritis

Kamm, J. Lacy; Frisbie, David D.; McIlwraith, C. Wayne; Orr, Kindra E

doi:10.2460/ajvr.74.1.115

Cited by 23 publications

(24 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Subsequently, upregulation of collagen genes, including COL1A, COL1A2, COL2 and COL3A1, is observed [3,41]. In horses, the effect of corticosteroid administration on the expression of collagen coding genes has been mixed.…”

Section: Discussionmentioning

confidence: 99%

Cytokine, catabolic enzyme and structural matrix gene expression in synovial fluid following intra‐articular administration of triamcinolone acetonide in exercised horses

Knych

Vidal

Chouicha

et al. 2016

Equine Veterinary Journal

View full text Add to dashboard Cite

This study supports the use of synovial fluid as a biological matrix for studying the effects of corticosteroids on gene expression. For the majority of genes studied the effects on expression relative to baseline for both inflammatory and matrix genes were prolonged relative to plasma and synovial fluid TA concentrations. Downregulation of collagen gene expression warrants the careful use of TA in horses.

show abstract

Section: Discussionmentioning

confidence: 99%

Cytokine, catabolic enzyme and structural matrix gene expression in synovial fluid following intra‐articular administration of triamcinolone acetonide in exercised horses

Knych

Vidal

Chouicha

et al. 2016

Equine Veterinary Journal

View full text Add to dashboard Cite

show abstract

“…In addition, several compounds can diffuse through the cartilage from the fluid or from the subchondral bone (Schultz et al 2011). Early identification of OA is critical for the prevention of disease progression (Kamm et al 2013). The stages include clinically silent disease, active (similar to a noninfectious inflammatory process) disease, and physical manifestation or decompensation.…”

Section: Corticosteroids For Intra-articular Treatmentmentioning

confidence: 99%

Osteoarthritis in horses - Part 2: a review of the intra-articular use of corticosteroids as a method of treatment

Souza

2016

Braz. arch. biol. technol.

View full text Add to dashboard Cite

show abstract

“…Moreover, the changes in blood gene expression may also indicate physiological processes associated with OA progression. The role of several factors in OA pathogenesis have been suggested based on the increased levels in peripheral blood samples [17, 18]. The molecules considered as promising biomarkers include hyaluronan, collagen epitopes, aggrecan, and matrix metalloproteinase-3 [19].…”

Section: Introductionmentioning

confidence: 99%

Blood Transcriptional Signatures for Disease Progression in a Rat Model of Osteoarthritis

Korostyński

Małek

Piechota

et al. 2017

International Journal of Genomics

View full text Add to dashboard Cite

Biomarkers of osteoarthritis (OA) that can accurately diagnose the disease at the earliest stage would significantly support efforts to develop treatments for prevention and early intervention. We have sought to determine the time course of alterations in peripheral blood gene expression profile associated with the development of OA. Blood samples were collected from a tail vein of individual rats with monosodium iodoacetate- (MIA-) induced OA (2, 14, 21, and 28 days after the treatment). We used whole-genome microarrays to reveal OA-related transcriptional alterations of 72 transcripts. Three main groups of coexpressed genes revealed diverse time-dependent profiles of up- and downregulation. Functional links that connect expression of the gradually downregulated genes to the G13 signaling pathway were indicated. The mRNA abundance levels of the identified transcripts were further analyzed in publicly available gene expression dataset obtained from a GARP study cohort of OA patients. We revealed three-gene signature differentially expressed in both rat and human blood (TNK2, KCTD2, and WDR37). The alterations in expression of the selected transcripts in peripheral blood samples of the patients indicate heterogeneity of the OA profiles potentially related to disease progress and severity of clinical symptoms. Our study identifies several potential stage-specific biomarkers of OA progression.

show abstract

Gene biomarkers in peripheral white blood cells of horses with experimentally induced osteoarthritis

Cited by 23 publications

References 26 publications

Cytokine, catabolic enzyme and structural matrix gene expression in synovial fluid following intra‐articular administration of triamcinolone acetonide in exercised horses

Cytokine, catabolic enzyme and structural matrix gene expression in synovial fluid following intra‐articular administration of triamcinolone acetonide in exercised horses

Osteoarthritis in horses - Part 2: a review of the intra-articular use of corticosteroids as a method of treatment

Blood Transcriptional Signatures for Disease Progression in a Rat Model of Osteoarthritis

Contact Info

Product

Resources

About