Gene–diet interactions on plasma lipid levels in the Inuit population

Rudkowska, Iwona; Dewailly, Éric; Hegele, Robert A.; Boiteau, Véronique; Dubé-Linteau, Ariane; Abdous, Belkacem; Giguère, Yves; Château-Degat, Marie-Ludivine; Vohl, Marie‐Claude

doi:10.1017/s0007114512002231

Cited by 52 publications

(47 citation statements)

References 41 publications

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“…Although there was no evidence that directly reported the association between rs709158 and the LDL-C level, Lu et al have reported that the SNP was associated with TC, which suggested a possible relationship between this SNP and LDL-C or HDL-C. Besides, another intronic SNP, rs10865710, included in this study has been reported to be associated with the LDL-C level that supported our findings (Rudkowska et al, 2013). What is presented above may give a provable view that mutants even in introns of PPAR genes could also affect the LDL-C level of humans.…”

Section: Discussionsupporting

confidence: 88%

Association and Interaction ofPPARα,δ,andγGene Polymorphisms with Low-Density Lipoprotein-Cholesterol in a Chinese Han Population

Fan

Shen

et al. 2015

Genetic Testing and Molecular Biomarkers

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Aims: Elevated low-density lipoprotein-cholesterol (LDL-C) is regarded as one of major risks of cardiovascular diseases and atherosclerotic events. It has been previously reported that peroxisome proliferatoractivated receptors (PPARs) play an important role in the regulation of lipid metabolism. In this study, we aimed to investigate the influence of PPARa/d/c gene polymorphisms on LDL-C level. Eight hundred twenty unrelated participants were recruited. Ten single-nucleotide polymorphisms (SNPs) were genotyped to analyze the gene-gene interactions among these polymorphisms using the generalized multifactor dimensionality reduction (GMDR) method. Results: The results of single-locus analyses indicated that the genotypes with minor allele variants at the rs1800206, rs9794, rs1805192, rs709158, and rs3856806 loci are associated with higher LDL-C levels ( p < 0.05) after adjusting for covariates. In contrast, individuals that were homozygous for the major allele (CC) of rs10865710 had significantly higher LDL-C than those with either one or more minor type alleles (CG + GG, mean difference: -0.21 mM; 95% confidence interval [CI]: -0.37 to -0.04 mM; p = 0.013). Significant gene-gene interactions among PPAR gene polymorphisms on LDL-C were identified by a generalized multifactor dimensionality reduction (GMDR) approach in 2-to 8-locus models ( p < 0.05). Conclusion: Our results provide evidence that multiple PPARa/d/c gene polymorphisms are individually associated with increased LDL-C, and that interactions, among these alleles result in additional increased risk suggesting that PPAR genes may contribute substantially to the risk of cardiovascular diseases and atherosclerosis.

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Section: Discussionsupporting

confidence: 88%

Association and Interaction ofPPARα,δ,andγGene Polymorphisms with Low-Density Lipoprotein-Cholesterol in a Chinese Han Population

Fan

Shen

et al. 2015

Genetic Testing and Molecular Biomarkers

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“…In 553 Inuit people, Rudkowska et al (2013) found that the rs5128 C allele frequency was 56.05%; however, we found that the rs5128 C allele frequency was 36.31%. Bhanushali and Das (2010) found that rs5128 was associated with dyslipidemia from a study in the Indian population.…”

Section: Discussioncontrasting

confidence: 75%

Relationship of the APOA5/A4/C3/A1 gene cluster and APOB gene polymorphisms with dyslipidemia

Ou¹,

Huang²,

Liu³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We determined the alleles of ten single nucleotide polymorphisms (SNPs) in the APOA5/A4/C3/A1 gene cluster and in APOB in Han Chinese from Xinjiang Shihezi, China using MALDI-TOF mass spectrometry, and explored the correlation between these SNPs and dyslipidemia through a case-control study design with 250 patients and 250 normal controls. All SNPs except for APOA5 rs2072560 conformed to Hardy-Weinberg equilibrium (all P > 0.05). APOA5 rs651821, APOA4 rs5104, APOC3 rs734104, and APOC3 rs5128 genotype and allele frequencies were significantly different between groups (all P < 0.01). For rs651821, the risks of dyslipidemia for the CC or H.J. Ou et al. 9278©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (3): 9277-9290 (2015) CC+CT genotypes were 9.917 or 1.859 times that of TT, and the risk of the C vs T allele was 2.027. For rs5104, the AG, GG, or AG+GG risks were 1.797, 1.861, and 1.809 times AA, and the G vs A risk was 1.427. For rs734104, the CT, CC, or CC+CT risks were 1.851, 2.570, and 1.958 times TT, and the C vs T risk was 1.610. For rs5128, the GC or CC+GC risks were 1.738 or 1.749 times GG, and the C vs G risk was 1.477. Compared with the wild-type haplotype TATG, the risks of dyslipidemia with CGCC, TGCC, or CATG haplotypes (odds ratios = 2.434, 1.503, and 2.740, respectively) were significantly higher. Our results suggested that these four SNPs were significantly associated with dyslipidemia in Xinjiang Shihezi Han Chinese, and might serve as risk factors for dyslipidemia. Individuals carrying the CGCC, TGCC, or CATG haplotypes were prone to dyslipidemia.

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“…In recent years, as the development of molecular biology and genetic engineering technologies has progressed, studies have demonstrated a close association between the ApoE gene polymorphism and serum lipid levels (Shin et al, 2014;Yin et al, 2014;Zhu et al, 2014). It has also been found that dietary factors had some impact on blood lipids, and that this effect could be modified by receptor lipoprotein metabolism (Petkeviciene et al, 2012;Rudkowska et al, 2013). Research data showed that the ApoE polymorphism had a highly significant impact on lipid concentrations (Petkeviciene et al, 2012;Rudkowska et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…It has also been found that dietary factors had some impact on blood lipids, and that this effect could be modified by receptor lipoprotein metabolism (Petkeviciene et al, 2012;Rudkowska et al, 2013). Research data showed that the ApoE polymorphism had a highly significant impact on lipid concentrations (Petkeviciene et al, 2012;Rudkowska et al, 2013). However, environmental factors, including living conditions, diet, and living habits, were also shown to affect blood lipid levels and cerebral infarction (CI) (Egert et al, 2012;Petkeviciene et al, 2012;Rudkowska et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…Research data showed that the ApoE polymorphism had a highly significant impact on lipid concentrations (Petkeviciene et al, 2012;Rudkowska et al, 2013). However, environmental factors, including living conditions, diet, and living habits, were also shown to affect blood lipid levels and cerebral infarction (CI) (Egert et al, 2012;Petkeviciene et al, 2012;Rudkowska et al, 2013). Therefore, this study focused on the relationship between the ApoE gene polymorphism and dietary factors in the association with plasma lipid concentrations.…”

Section: Introductionmentioning

confidence: 99%

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Association of the ApoE gene polymorphism and dietary factors with cerebral infarction and circulating lipid concentrations

et al. 2015

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ABSTRACT. The aim of this study was to explore the relationship between the ApoE gene polymorphism and dietary factors with stroke and circulating lipid levels in the Chinese population. We selected 580 patients with stroke and 580 age-and gender-matched healthy controls, and examined their ApoE polymorphism genotype using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. We also analyzed the relationship between the ApoE gene polymorphism and dietary factors as well as plasma lipid concentrations in this cohort. We detected six ApoE genotypes in the study populations, and determined that the E4 allele was positively associated with cerebral infarction (CI), whereas allele E2 was negatively associated with total cholesterol (TC) and low-density lipoprotein-cholesterol levels. The dietary habits of the subjects with descending order of average total TC and triglyceride levels were: subjects addicted to oily food > subjects addicted to sweets > subjects addicted to smoking > subjects addicted to alcohol > subjects following a vegetarian diet (P < 0.05). Our results demonstrated that the ApoE gene polymorphism was associated with a risk for CI in a Chinese population.

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Gene–diet interactions on plasma lipid levels in the Inuit population

Cited by 52 publications

References 41 publications

Association and Interaction ofPPARα,δ,andγGene Polymorphisms with Low-Density Lipoprotein-Cholesterol in a Chinese Han Population

Association and Interaction ofPPARα,δ,andγGene Polymorphisms with Low-Density Lipoprotein-Cholesterol in a Chinese Han Population

Relationship of the APOA5/A4/C3/A1 gene cluster and APOB gene polymorphisms with dyslipidemia

Association of the ApoE gene polymorphism and dietary factors with cerebral infarction and circulating lipid concentrations

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