2018
DOI: 10.1002/cbic.201800592
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Gene Discovery in Gelsemium Highlights Conserved Gene Clusters in Monoterpene Indole Alkaloid Biosynthesis

Abstract: Genome mining is a routine technique in microbes for discovering biosynthetic pathways. In plants, however, genomic information is not commonly used to identify novel biosynthesis genes. Here, we present the genome of the medicinal plant and oxindole monoterpene indole alkaloid (MIA) producer Gelsemium sempervirens (Gelsemiaceae). A gene cluster from Catharanthus roseus, which is utilized at least six enzymatic steps downstream from the last common intermediate shared between the two plant alkaloid types, is f… Show more

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Cited by 77 publications
(90 citation statements)
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“…Indole alkaloids are produced by plants using a series of unique biosynthetic pathways, leading to an impressive diversity of complex natural products . Many indole alkaloids are endowed with significant biological activities important to human health and the treatment of disease (Scheme ) . The indole alkaloids vincristine ( 88 ) and vinblastine ( 70 ) were discovered in Catharanthus roseus (Madagascar periwinkle) and have had a remarkable impact on cancer therapies over the past several decades .…”
Section: Indole Alkaloid Natural Products and Indole‐based Small Molementioning
confidence: 99%
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“…Indole alkaloids are produced by plants using a series of unique biosynthetic pathways, leading to an impressive diversity of complex natural products . Many indole alkaloids are endowed with significant biological activities important to human health and the treatment of disease (Scheme ) . The indole alkaloids vincristine ( 88 ) and vinblastine ( 70 ) were discovered in Catharanthus roseus (Madagascar periwinkle) and have had a remarkable impact on cancer therapies over the past several decades .…”
Section: Indole Alkaloid Natural Products and Indole‐based Small Molementioning
confidence: 99%
“…With the significant therapeutic value of indole alkaloids and derived natural products (e.g., quinine 100 , camptothecin 102 ; quinoline‐derived alkaloids from strictosidine; Scheme ), extensive investigations regarding the biosynthetic pathways of these alkaloids has been an area of intense interest . Many details regarding the enzymes and chemical transformations involved in the biosynthesis of monoterpene indole alkaloids have been elucidated; however, additional information is needed to fully elucidate these pathways.…”
Section: Indole Alkaloid Natural Products and Indole‐based Small Molementioning
confidence: 99%
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