Gene drives and the management of agricultural pests

Medina, Raúl F.

doi:10.1080/23299460.2017.1407913

Cited by 18 publications

(15 citation statements)

References 40 publications

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“…However, gene drive has also been shown in agriculture with the CRISPR era. Alternative solutions were proposed to use CRISPR drive in the management of plant pathogens, pests, and weeds ( Medina, 2018 ; Neve, 2018 ; Barrett et al, 2019 ; Gardiner et al, 2020 ).…”

Section: Subsectionsmentioning

confidence: 99%

“…Although HEG drive is a powerful tool that can manipulate the population, the most significant lack of HEG-based gene drives is that the endonuclease recognition sites are not common naturally. Even though different study groups have designed different gene drives for pests, the application of these gene drives was limited due to the target region problem, but CRISPR/Cas9 brought a new solution to this problem ( Burt and Koufopanou, 2004 ; Schliekelman et al, 2005 ; Sinkins and Gould, 2006 ; Bax and Thresher, 2009 ; Medina, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

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A New Approach to Develop Resistant Cultivars Against the Plant Pathogens: CRISPR Drives

Tek

Kübra

2022

Front. Plant Sci.

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CRISPR drive is a recent and robust tool that allows durable genetic manipulation of the pest population like human disease vectors such as malaria vector mosquitos. In recent years, it has been suggested that CRISPR drives can also be used to control plant diseases, pests, and weeds. However, using a CRISPR drive in Arabidopsis for the first time in 2021 has been shown to use this technology in plant breeding to obtain homozygous parental lines. This perspective has proposed using CRISPR drive to develop pathogen-resistant cultivars by disrupting the susceptibility gene (S). In the breeding program, CRISPR is used to create S-gene mutations in two parental lines of hybrid cultivars. However, CRISPR must be reapplied or long-term backcrossed for the parental line to obtain homozygous S-mutant cultivars. When a parental line crosses with different parental lines to develop new hybrids, heterozygous S-mutations could not resist in hybrid against the pathogen. CRISPR drives are theoretically valid to develop homozygous S-mutant plants against pathogens by only routine pollination after CRISPR drive transformation to just one parental line. This way, breeders could use this parental line in different crossing combinations without reapplying the genome-editing technique or backcrossing. Moreover, CRISPR drive also could allow the development of marker-free resistant cultivars with modifications on the drive cassette.

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Section: Subsectionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A New Approach to Develop Resistant Cultivars Against the Plant Pathogens: CRISPR Drives

Tek

Kübra

2022

Front. Plant Sci.

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“…The current strategies focus on population suppression to eliminate the pest population. 22 , 23 Another potential application of gene drive technology is environmental conservation by the eradication of invasive species, such as introduced rats on islands. 24 – 26 Alternatively, the population modification concept can be used to use gene drives to spread beneficial traits or remove deleterious mutations in endangered species.…”

Section: Gene Drive Concept and Applicationsmentioning

confidence: 99%

Global Governing Bodies: A Pathway for Gene Drive Governance for Vector Mosquito Control

Kelsey

Stillinger

Pham

et al. 2020

The American Journal of Tropical Medicine and Hygiene

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Gene drive technologies represent powerful tools to develop vector control strategies that will complement the current approaches to mitigate arthropod-borne infectious diseases. The characteristics of gene drive technologies have raised additional concerns to those for standard genetically engineered organisms. This generates a need for adaptive governance that has not been met yet because of the rapid rate of progress in gene drive research. For the eventual release of gene drive insects into wild populations, an international governance network would be helpful in guiding scientists, stakeholders, public opinion, and affected communities in its use. We examined the current institutions and governing bodies among various continents that could have an impact on gene drive governance or the potential to adapt to its future use. Possible governance strategies also are proposed that seek to bridge gaps and promote an ethically sound policy framework. Ideally, governance strategies should be developed before or at the same pace as gene drive research to anticipate field releases and maximize their impact as a public health tool. However, this is not likely to happen as it takes years to develop global accords, and some countries may choose to move ahead independently on the new technology.

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“…Genes implicated in development, feeding, reproduction, and the immune system are desirable targets for pest control. The quick spread of mutations created by CRISPR/Cas distorts the sex ratio, decreases fitness, or eliminates insecticide resistance in the targeted population (Courtier‐Orgogozo et al ., 2017; Medina, 2018). The two forms of CRISPR/Cas‐based sex ratio‐distorting gene drives—homing gene drives and the X‐shredder (X‐S)—both drive maleness, with the resulting paucity of females causing the extinction of ecosystem‐harming populations.…”

Section: Mutagenesis and Crispr/cas Approaches For B Tabaci Controlmentioning

confidence: 99%

Biotechnological interventions for the sustainable management of a global pest, whitefly (Bemisia tabaci)

et al. 2020

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Whiteflies (Bemisia tabaci) are polyphagous invasive hemipteran insects that cause serious losses of important crops by directly feeding on phloem sap and transmitting pathogenic viruses. These insects have emerged as a major threat to global agriculture and food security. Chemically synthesized insecticides are currently the only option to control whiteflies, but the ability of whiteflies to evolve resistance against insecticides has made the management of these insects very difficult. Natural host-plant resistance against whiteflies identified in some crop plants has not been exploited to a great extent. Genetic engineering approaches, such as transgenics and RNA interference (RNAi), are potentially useful for the control of whiteflies. Transgenic plants harboring insecticidal toxins/lectins developed via nuclear or chloroplast transformation are a promising vehicle for whitefly control. Double-stranded RNAs (dsRNAs) of several insect genes, delivered either through microinjection into the insect body cavity or orally via an artificial diet and transiently or stably expressed in transgenic plants, have controlled whiteflies in model plants and in some crops at the laboratory level, but not at the field level. In this review, we highlight the merits and demerits of each delivery method along with strategies for sustained delivery of dsRNAs via fungal entomopathogen/endosymbiont or nontransgenic RNAi approaches, foliar sprays, root absorption or nanocarriers as well as the factors affecting efficient RNAi and their biosafety issues. Genome sequencing and transcriptome studies of whitefly species are facilitating the selection of appropriate genes for RNAi and gene-editing technology for the efficient and resilient management of whiteflies and their transmitted viruses.

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Gene drives and the management of agricultural pests

Cited by 18 publications

References 40 publications

A New Approach to Develop Resistant Cultivars Against the Plant Pathogens: CRISPR Drives

A New Approach to Develop Resistant Cultivars Against the Plant Pathogens: CRISPR Drives

Global Governing Bodies: A Pathway for Gene Drive Governance for Vector Mosquito Control

Biotechnological interventions for the sustainable management of a global pest, whitefly (Bemisia tabaci)

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