Gene–environment interaction: New insights into perceived parenting and social anxiety among adolescents

Chubar, Viktoria; Leeuwen, Karla Van; Bijttebier, Patricia; Assche, Evelien Van; Bosmans, Guy; Noortgate, Wim Van den; Winkel, Ruud van; Goossens, Luc; Claes, Stephan

doi:10.1192/j.eurpsy.2020.62

Cited by 12 publications

(6 citation statements)

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“…Possible explanations could be that childhood psychiatric disorders might be influenced by environmental or epigenetic factors [ 39 ]. The upbringing and surroundings of multiple offspring differ from those of singletons, and certain family and social factors, such as strict parenting, could contribute to these differences in environmental and epigenetic factors [ 40 ]. Additionally, while our study suggests that multiple pregnancies themselves may not increase the risk of psychiatric disorders in offspring, pregnant women with multiple pregnancies may be more susceptible to various pregnancy complications [ 41 , 42 ], some of which, such as preterm birth [ 43 ], have been associated with psychiatric disorders in offspring [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Long-term outcomes of offspring from multiple gestations: a two-sample Mendelian randomization study on multi-system diseases using UK Biobank and FinnGen databases

Jiang,

Du,

et al. 2023

J Transl Med

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Background Assisted reproductive technologies (ART) have increased the incidence of multiple births, which can have a negative impact on maternal and offspring health. The study aimed to investigate the association between genetically predicted multiple birth and the risk of 42 common diseases of the nervous, psychiatric, cardiovascular, respiratory, digestive, and endocrine systems. Methods The study utilized two-sample Mendelian randomization (MR) analysis to explore the potential causal relationship between genetically predicted multiple birth and the genetically predicted risk of diseases. The study used the FinnGen and UK Biobank datasets for analysis. Results The study found no significant causal relationship between multiple birth and psychiatric disorders. However, the lower limits of the 95% confidence intervals for bipolar affective disorder and anxiety disorders were not robust, indicating a need for further investigation. The study found that multiple birth may be a strong risk factor for infantile cerebral palsy, and caution is necessary in both natural and ART multiple births. The study revealed a potential causal relationship between multiple birth and coronary heart disease, ischemic heart disease, and deep vein thrombosis, which may be related to abnormal intrauterine environments in multiple pregnancies. Surprisingly, multiple birth appears to have a protective effect against some respiratory diseases, such as chronic obstructive pulmonary disease and asthma. Conclusions The study highlights the need for caution regarding the risk of infantile cerebral palsy, cardiovascular diseases, and psychiatric disorders in multiple birth. Our study can lead to the development of preventive strategies and improved clinical management for affected infants.

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Section: Discussionmentioning

confidence: 99%

Long-term outcomes of offspring from multiple gestations: a two-sample Mendelian randomization study on multi-system diseases using UK Biobank and FinnGen databases

Jiang,

Du,

et al. 2023

J Transl Med

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“…Additionally, in the PWAS analysis of different gender populations, multiple candidate genes associated with PTSD were identified in the male and female populations, such as GLO1 and GSTZ1 in females and AKT3 and MAPK8IP3 in males. Among the candidate genes in the female population, the GLO1 gene was discussed in the previous passages on overlapping genes; GSTZ1 (glutathione S-transferase Zeta 1) is a member of the glutathione S-transferase super-family, responsible for glutathione-dependent metabolism and involved in the regulation of oxidative stress [ 42 ]. Previous studies have found many genetic polymorphisms in the coding and promoter regions of the GSTZ1 gene, having significant effects on the protein’s kinetic characteristics and/or its expression levels [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

“…Another related study found that polymorphisms in the GSTZ1 gene were associated with early-onset susceptibility to bipolar disorder [ 44 ]. Furthermore, a gene–environment interaction study suggested that GSTZ1 is related to genes associated with harsh punitive parenting, which may contribute to social anxiety in adolescence [ 42 ]. The possible mechanism is that this gene is involved in biological pathways that regulate oxidative stress and glutamate neurotransmission associated with anxiety-like behavior and may be sensitive to stressful life events during development.…”

Section: Discussionmentioning

confidence: 99%

Brain Proteome-Wide Association Study Identifies Candidate Genes that Regulate Protein Abundance Associated with Post-Traumatic Stress Disorder

Zhang

Meng

Zhang

et al. 2022

Genes

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Although previous genome-wide association studies (GWASs) on post-traumatic stress disorder (PTSD) have identified multiple risk loci, how these loci confer risk of PTSD remains unclear. Through the FUSION pipeline, we integrated two human brain proteome reference datasets (ROS/MAP and Banner) with the PTSD GWAS dataset, respectively, to conduct a proteome-wide association study (PWAS) analysis. Then two transcriptome reference weights (Rnaseq and Splicing) were applied to a transcriptome-wide association study (TWAS) analysis. Finally, the PWAS and TWAS results were investigated through brain imaging analysis. In the PWAS analysis, 8 and 13 candidate genes were identified in the ROS/MAP and Banner reference weight groups, respectively. Examples included ADK (pPWAS-ROS/MAP = 3.00 × 10−5) and C3orf18 (pPWAS-Banner = 7.07 × 10−31). Moreover, the TWAS also detected multiple candidate genes associated with PTSD in two different reference weight groups, including RIMS2 (pTWAS-Splicing = 3.84 × 10−2), CHMP1A (pTWAS-Rnaseq = 5.09 × 10−4), and SIRT5 (pTWAS-Splicing = 4.81 × 10−3). Further comparison of the PWAS and TWAS results in different populations detected the overlapping genes: MADD (pPWAS-Banner = 4.90 × 10−2, pTWAS-Splicing = 1.23 × 10−2) in the total population and GLO1(pPWAS-Banner = 4.89 × 10−3, pTWAS-Rnaseq = 1.41 × 10−3) in females. Brain imaging analysis revealed several different brain imaging phenotypes associated with MADD and GLO1 genes. Our study identified multiple candidate genes associated with PTSD in the proteome and transcriptome levels, which may provide new clues to the pathogenesis of PTSD.

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“…A large body of research has demonstrated that parenting characteristics such as overprotection (Yaffe, 2021), harsh punitive control (Chubar et al, 2020), intrusive and manipulative control (Gómez-Ortiz et al, 2019), lower autonomy support (Nelemans et al, 2020), rejection (Smout et al, 2019) are also associated with social anxiety. Longitudinal studies have demonstrated that parenting behavior has an impact on the emotion regulation strategies that children with behavioral inhibition use, which in turn contributes to social anxiety outcomes (Suarez et al, 2021).…”

Section: Literature Reviewmentioning

confidence: 99%

"Early Negative Memories, Humiliation and Defectiveness/Shame Schema: An Emotion-Focused Therapeutic Approach to Social Anxiety"

ASMARI¹,

DOLATSHAHI²,

Poursharifi³

et al. 2022

JEBP

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"Introduction: Recently emotion-focused therapy has developed as an additional approach and considers the role of primary emotions such as shame in the formation and persistence of SAD. Objectives: The purpose of this study was to investigate the theoretical model of emotion-focused therapy for SAD by considering the role of early negative memories, humiliation and the mediating role of self-defectiveness/shame schema in the etiology of SAD. Method: This cross-sectional descriptive study recruited a sample of 105 students, 44 males (41.9%) 61 females (58.1%), diagnosed with SAD by psychologists from Shahid Beheshti University Counseling Center. Participants ranging in age from 18 to 34 with a mean age of 23.1 years (SD=3.5) completed the Social Phobia Inventory, Humiliation Inventory, Early Life Experiences Scale, Defectiveness /Shame Schema subscale of the Young Schema Questionnaire-Short Form. Results: Data were analyzed using SmartPLS-SEM. The results showed that early childhood experiences and humiliation significantly predict SAD. Also, the indirect effects of the independent variables through defectiveness/shame schema on SAD were significant. Conclusions: Consistent with the assumptions of the emotion-focused approach to SAD, these results confirm that early life experiences and humiliation with the development of shame schemes play an important role in the etiology of SAD and must be considered for therapy to be effective. The results of this study suggest that the components of the emotion-focused model can have therapeutic value as targets of intervention in randomized clinical trials."

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Gene–environment interaction: New insights into perceived parenting and social anxiety among adolescents

Cited by 12 publications

References 69 publications

Long-term outcomes of offspring from multiple gestations: a two-sample Mendelian randomization study on multi-system diseases using UK Biobank and FinnGen databases

Long-term outcomes of offspring from multiple gestations: a two-sample Mendelian randomization study on multi-system diseases using UK Biobank and FinnGen databases

Brain Proteome-Wide Association Study Identifies Candidate Genes that Regulate Protein Abundance Associated with Post-Traumatic Stress Disorder

"Early Negative Memories, Humiliation and Defectiveness/Shame Schema: An Emotion-Focused Therapeutic Approach to Social Anxiety"

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