Gene-environment interactions between GSTs polymorphisms and targeted epigenetic alterations in hepatocellular carcinoma following organochlorine pesticides (OCPs) exposure

Tian, Meiping; Zhao, Bin; Martin, Francis; Morais, Camilo L. M.; Liu, Liangpo; Huang, Qingyu; Zhang, Jie; Shen, Heqing

doi:10.1016/j.envint.2019.105313

Cited by 20 publications

(14 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In agreement with the findings of the present study, Tian et al indicated a significant association between OCPs exposure and methylation of tumor suppressor genes in hepatocellular carcinoma (21). In another study, it was shown that upon OCPs exposure, DNA methyltransferases were upregulated in MCF-7 cells (2).…”

Section: Discussionsupporting

confidence: 92%

MGMT methylation alterations in brain cancer following organochlorine pesticides exposure

Yousefi

Asadikaram

Karamouzian

et al. 2021

Environ Health Eng Manag

View full text Add to dashboard Cite

Background: Alterations in the methylation levels of tumor suppressor genes are considered as one of the essential aspects of malignancies. The present study explored the association of O6-methylguanine-DNA methyltransferase (MGMT) gene promoter methylation, as a tumor suppressor, with some organochlorine pesticides (OCPs) in primary brain tumor (PBT) patients. Methods: The present study was conducted on a total of 73 PBT patients. The patients’ serum was analyzed using gas chromatography for seven OCP derivatives. The methylation-specific PCR (MSP) method was also used to determine the methylation status of the MGMT promoter. Results: The current findings demonstrated that the methylation of MGMT promoter occurred in 22 out of 34 glioma cases (64%), but in only one out of 35 meningioma cases. No MGMT promoter methylation was observed in other PBT, hemangioma, and anaplastic medulloblastoma stages. Besides, there were significant associations between MGMT methylation and γ-HCH (odds ratio [OR]: 1.50; 95% CI: 1.03- 2.40, P=0.04), 4,4DDE (OR: 1.44; 95% CI: 1.01- 2.05, P=0.02), 2,4 DDT (OR: 1.23; CI: 1.04- 1.45, P=0.03), and 4,4DDT (OR: 1.46; CI: 1.23- 2.15, P=0.02) in glioma patients. Conclusion: The results of the study suggested that the hypermethylation of the MGMT promoter in glioma patients is associated with increased OCPs in their serum, especially γ- HCH, 4,4DDE, 2,4DDT, and 4,4DDT. Moreover, it may lead to the hypermethylation of the MGMT promoter gene. Hence, it can be concluded that exposure to OCPs may potentially induce glioma.

show abstract

Section: Discussionsupporting

confidence: 92%

MGMT methylation alterations in brain cancer following organochlorine pesticides exposure

Yousefi

Asadikaram

Karamouzian

et al. 2021

Environ Health Eng Manag

View full text Add to dashboard Cite

show abstract

“…Therefore, individuals with the mutant variant have reduced enzyme activity that make them susceptible to oxidative stress and unable to detoxify cancer-causing xenobiotics (Fig. 2) [13,[37][38][39]. [17,27,28].…”

Section: Genes Involved In the Metabolism Of Xenobioticsmentioning

confidence: 99%

Genetic profile for the detection of susceptibility to poisoning by exposure to pesticides

Galvez¹,

Salazar-Flores²,

Sanchez³

et al. 2021

Ann Agric Environ Med.

View full text Add to dashboard Cite

show abstract

“…In the past few years, the influence of XME polymorphisms in DNA damage has been given more importance [39,94,95]. The emphasis is on identifying the interaction between polymorphic gene and many pesticides in the gene-environment.…”

Section: Associations Between Polymorphism Of Xme and Dna Damagementioning

confidence: 99%

“…Therefore, it may be commented that individuals with null deletions of GSTT1 and / or GSTM1 are more vulnerable to DNA damage and cancers (such as melanoma, urinary bladder cancer, epithelial ovarian cancers etc) than their positive counterparts when exposed to the same pesticides. The change in vulnerability can be due to polymorphisms in the XMEs which were thought to modulate the pesticide-induced cytogenetic changes through gene-environment interaction [95].…”

Section: Associations Between Polymorphism Of Xme and Dna Damagementioning

confidence: 99%

Genetic Polymorphisms and Pesticide-Induced DNA Damage: A Review

Usman¹,

Priya²,

Pandit³

et al. 2021

TOBIOTJ

View full text Add to dashboard Cite

The drastic increase in pesticide applications makes human exposure inevitable either through environment or occupation. Pesticide toxicity causes many adverse health effects through a number of pathways leading to DNA damage, mutations and cancers. Nevertheless, there is heterogeneity in the degree of toxicity among individuals due to the influence of genetic polymorphisms on xenobiotic metabolizing enzymes (XMEs) that modulate the biological process. Thus, study of the most common polymorphic genes coding for the enzymes involved in pesticide metabolism (such as cytochrome P450, Glutathione S-transferases, N-acetyltransferase and paraoxonase) may help determine individual’s susceptibility to pesticide toxicity. In this review, we give an overview of some recent developments in the field of genetic polymorphism and pesticide-related DNA damage, including probable biomarkers that may uncover genome susceptibility to pesticide toxicity. We have tried to create a connection between DNA polymorphism and cancer onslaught globally. It is envisaged that knowledge on this line would improve our understanding of facilitating the association between genotype and phenotype in cancer biology.

show abstract

Gene-environment interactions between GSTs polymorphisms and targeted epigenetic alterations in hepatocellular carcinoma following organochlorine pesticides (OCPs) exposure

Cited by 20 publications

References 62 publications

MGMT methylation alterations in brain cancer following organochlorine pesticides exposure

MGMT methylation alterations in brain cancer following organochlorine pesticides exposure

Genetic profile for the detection of susceptibility to poisoning by exposure to pesticides

Genetic Polymorphisms and Pesticide-Induced DNA Damage: A Review

Contact Info

Product

Resources

About