2022
DOI: 10.31234/osf.io/wkeqn
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Gene-environment Interplay in Early Life Cognitive Development

Abstract: Individual differences in early life cognitive development are driven by the interplay of genetic and environmental factors, but identifying replicable gene-environment interactions (GxE) has proven difficult. Here, we systematically tested GxE effects in the prediction of cognitive development from 2 to 4 years, using polygenic scores (PGS) for years spent in education and 39 measures of the home and neighborhood environment. Data came from up to 6,973 unrelated individuals from the Twins Early Development St… Show more

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“…Adjusting for family SES did not alter the effect size of the observed C influences; thus, the C effects that drive the influence of earlier household chaos on later educational achievement are distinct from family SES (Hart et al, 2007). We can only speculate about the kinds of shared environments that may be involved, for example the parenting that children experience in the family home, the school environment that they experience, and the wider neighbourhood conditions (e.g., Engelhardt, Church, Harden, & Tucker-Drob, 2018;Nieuwenhuis & Hooimeijer, 2016;Pinquart, Special Collection: npj Science of Learning Votruba-Drzal, 2015;von Stumm, Kandaswamy, & Maxwell, 2022), they also include variance that is not shared with SES and that may drive the here observed C influences. Further research using genetically sensitive designs is needed to investigate the underlying mechanisms behind these potential environmental factors and to test whether these might act as malleable causal influences on children's educational success after controlling for genetic and environmental confounding.…”
Section: Discussionmentioning
confidence: 99%
“…Adjusting for family SES did not alter the effect size of the observed C influences; thus, the C effects that drive the influence of earlier household chaos on later educational achievement are distinct from family SES (Hart et al, 2007). We can only speculate about the kinds of shared environments that may be involved, for example the parenting that children experience in the family home, the school environment that they experience, and the wider neighbourhood conditions (e.g., Engelhardt, Church, Harden, & Tucker-Drob, 2018;Nieuwenhuis & Hooimeijer, 2016;Pinquart, Special Collection: npj Science of Learning Votruba-Drzal, 2015;von Stumm, Kandaswamy, & Maxwell, 2022), they also include variance that is not shared with SES and that may drive the here observed C influences. Further research using genetically sensitive designs is needed to investigate the underlying mechanisms behind these potential environmental factors and to test whether these might act as malleable causal influences on children's educational success after controlling for genetic and environmental confounding.…”
Section: Discussionmentioning
confidence: 99%