Gene expression analysis of peripheral T cells in a subgroup of common variable immunodeficiency shows predominance of CCR7– effector-memory T cells

Holm, Are Martin; Sivertsen, Einar Andreas; Tunheim, Siv H.; Haug, Terje; Bjerkeli, Vigdis; Yndestad, Arne; Aukrust, Pål; Frøland, Stig S.

doi:10.1111/j.1365-2249.2004.02630.x

Cited by 39 publications

(22 citation statements)

References 44 publications

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“…An increase in a subgroup of CD8 + T cells with cytotoxic effector memory expression markers has been reported in CVID patients. These CCR7 -T cells are similar to chronically activated T cells with an impaired proliferation response [71]. Within the CD8 + T-cell subpopulation, CD8 + effector memory cells are significantly less frequent in organ-specific autoimmune disease, whereas terminally differentiated CD8 + cells are significantly more frequent in CVID patients with polyclonal lymphoid proliferation and autoimmune cytopenias [13].…”

Section: Cd27mentioning

confidence: 71%

T-Cell Abnormalities in Common Variable Immunodeficiency

Azizi

Rezaei

Kiaee

et al. 2016

J Investig Allergol Clin Immunol

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Common variable immunodeficiency (CVID) is the most common clinical primary immunodeficiency. It is characterized by a defect in B-cell differentiation to plasma and memory B cells. Moreover, numerous T-cell abnormalities have been reported and include decreased T-cell count and proliferative response, increased T-cell activation and apoptosis, and abnormalities in cytokine production. The aims of this review are to describe phenotypic and functional defects in T cells in CVID patients and to review the literature with respect to the effects of immunoglobulin replacement on the T-cell component in CVID patients. Key words: Common variable immunodeficiency. T cell. Helper T cells. Regulatory T cells. ResumenLa inmunodeficiencia común variable (CVID) es la inmunodeficiencia primaria más frecuente. Se caracteriza por un defecto en la diferenciación de linfocitos B hacia células plasmáticas y linfocitos B memoria. Se han descrito numerosas alteraciones en los linfocitos T de estos pacientes, tales como disminución en el número de linfocitos T y en sus respuestas proliferativas, aumento en la activación de células T y en la apoptosis, así como alteraciones en la producción de citokinas. El objetivo de esta revisión es describir las alteraciones funcionales y fenotípicas de los linfocitos T en los pacientes con CVID y revisar la bibliografía en relación a los efectos que la administración de inmunoglobulinas produce en los linfocitos T de los pacientes con CVID. Palabras clave: Inmunodeficiencia común variable. Células T. Células T helper. Células T reguladoras.

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Section: Cd27mentioning

confidence: 71%

T-Cell Abnormalities in Common Variable Immunodeficiency

Azizi

Rezaei

Kiaee

et al. 2016

J Investig Allergol Clin Immunol

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“…In fact, the 13 CVID IL-7high patients had significantly higher CD8 ϩ T-cell counts than the remaining patients (1043 [299-2040] vs 531 [353-722] CD3 ϩ CD8 ϩ cells/mm 3 ; P ϭ .02). There were no different proportions of CD45RA ϩ T cells, but the predominance of CCR7 Ϫ effector-memory T cells 11,12 was significantly stronger in the CVID IL-7high patients (88% [75%-90%] vs 68% [45%-90%] CCR7 Ϫ of CD3 ϩ cells; P ϭ .01). There was no difference in the expression of the proliferation marker Ki67 between CVID and controls or between the CVID IL-7high and the remaining patients, indicating that the increased numbers of CD8 ϩ T cells were not due to increased proliferation in vivo.…”

Section: Resultsmentioning

confidence: 95%

“…We describe a subgroup of CVID patients with high plasma levels of IL-7, associated with elevated numbers of CD8 ϩ T cells and increased proportion of terminally differentiated effector-memory T cells 11,12 that do not show signs of increased proliferation, but appear to have reduced apoptosis. Some of these patients also have reduced response to IL-7 in vitro.…”

Section: Resultsmentioning

confidence: 99%

Abnormal interleukin-7 function in common variable immunodeficiency

Holm¹,

Aukrust²,

Damås³

et al. 2005

Blood

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“…2,14 The immunophenotypic characteristics found in our CVID group are comparable to those reported previously in the literature: increased naïve and transitional B cells, CD21 37,38 and decreased CCR7 expression on T cells, especially on cTfh cells. 38,39 It should be noted that the observed reduction of BAFF-R in CVID might be an overestimation because BAFF-R expression levels are lower on CD27 -B cells, the predominant B-cell subset in these patients.…”

Section: Discussionmentioning

confidence: 99%

The immunophenotypic fingerprint of patients with primary antibody deficiencies is partially present in their asymptomatic first-degree relatives

et al. 2016

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T he etiology of primary antibody deficiencies is largely unknown. Beside rare monogenic forms, the majority of cases seem to have a more complex genetic basis. Whereas common variable immunodeficiency has been investigated in depth, there are only a few reports on milder primary antibody deficiencies such as idiopathic primary hypogammaglobulinemia and IgG subclass deficiency. We performed flow cytometric immunophenotyping in 33 patients with common variable immunodeficiency, 23 with idiopathic primary hypogammaglobulinemia and 21 with IgG subclass deficiency, as well as in 47 asymptomatic first-degree family members of patients and 101 unrelated healthy controls. All three groups of patients showed decreased memory B-and naïve T-cell subsets and decreased B-cell activating factor receptor expression. In contrast, circulating follicular helper T-cell frequency and expression of inducible T-cell costimulator and chemokine receptors were only significantly altered in patients with common variable immunodeficiency. Asymptomatic firstdegree family members of patients demonstrated similar, albeit intermediate, alterations in naïve and memory B-and T-cell subsets. About 13% of asymptomatic relatives had an abnormal peripheral B-cell composition. Furthermore, asymptomatic relatives showed decreased levels of CD4 + recent thymic emigrants and increased central memory T cells. Serum IgG and IgM levels were also significantly lower in asymptomatic relatives than in healthy controls. We conclude that, in our cohort, the immunophenotypic landscape of primary antibody deficiencies comprises a spectrum, in which some alterations are shared between all primary antibody deficiencies whereas others are only associated with common variable immunodeficiency. Importantly, asymptomatic first-degree family members of patients were found to have an intermediate phenotype for peripheral Band T-cell subsets.

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Gene expression analysis of peripheral T cells in a subgroup of common variable immunodeficiency shows predominance of CCR7– effector-memory T cells

Cited by 39 publications

References 44 publications

T-Cell Abnormalities in Common Variable Immunodeficiency

T-Cell Abnormalities in Common Variable Immunodeficiency

Abnormal interleukin-7 function in common variable immunodeficiency

The immunophenotypic fingerprint of patients with primary antibody deficiencies is partially present in their asymptomatic first-degree relatives

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