Gene expression and estrogen sensitivity in rat uterus after developmental exposure to the polybrominated diphenylether PBDE 99 and PCB

Ceccatelli, Raffaella; Faass, Oliver; Schlumpf, Margret; Lichtensteiger, W.

doi:10.1016/j.tox.2005.12.004

Cited by 114 publications

(96 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, Kuriyama et al (2006) found that after a single administration of BDE-99 (0.06 or 0.3 mg/kg) to dams on GD 6, hepatic levels were much higher in pups than in dams on PND 1-22, suggesting that gestational exposure leads to long-term body burden. In support of this finding, Ceccatelli et al (2006) found that administration to rats of BDE-99 (1 or 10 mg/kg from GD 10 to GD 18) resulted in significant plasma and adipose tissue levels in pups at 120 days of age.…”

Section: Toxicokinetic Studiesmentioning

confidence: 66%

“…This approach bypasses the need to quantify exposure from different routes and to consider species-specific toxicokinetics aspects, as body burden data are an integrated measure of exposure from all routes (McDonald, 2005). For example, following prenatal exposure to BDE-99 (1 mg/kg from GD 10 to GD 18) plasma levels of pups at PND 120 were 0.95 ng/ml (Ceccatelli et al 2006). Assuming a total lipid content of rat plasma of 2 mg lipid/ml, this corresponds to 475 ng BDE-99/g lipid.…”

Section: Relevance To Humansmentioning

confidence: 99%

“…Assuming a total lipid content of rat plasma of 2 mg lipid/ml, this corresponds to 475 ng BDE-99/g lipid. It should be noted that the study by Ceccatelli et al (2006) examined effects on gene expression in the uterus, rather than alterations in the nervous system; however, upon identical exposure, changes in sexual behavior and sweet preference were also found (Lichtensteiger et al 2004;Lilienthal et al 2006). Levels in human plasma as high as 580 and 460 ng/g lipid have been reported in maternal and fetal blood, respectively (Table 6; Mazdai et al 2003).…”

Section: Relevance To Humansmentioning

confidence: 99%

See 2 more Smart Citations

Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants

2007

View full text Add to dashboard Cite

show abstract

Section: Toxicokinetic Studiesmentioning

confidence: 66%

Section: Relevance To Humansmentioning

confidence: 99%

Section: Relevance To Humansmentioning

confidence: 99%

See 1 more Smart Citation

Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants

2007

View full text Add to dashboard Cite

show abstract

“…BDE-99, -100 and -153 did not induce ER, but they were weakly antiestrogenic at concentrations 3 -10 μM in the models containing either ERα or ERβ (Kojima et al, 2009). Up-regulation of ERα, ERβ and increased ovarian weight have been reported in Long-Evans rats exposed to BDE-99 (Ceccatelli et al, 2006).…”

Section: Estrogenicity/antiestrogenicity Of Pbdesmentioning

confidence: 97%

“…The same treatment protocol in male offspring permanently impaired spermatogenesis by the means of reduced sperm and spermatid counts . In another study in which adult female Long-Evans rats were exposed by subcutaneous injection to 1 or 10 mg/kg per day from GD10-18, offspring exhibited unchanged uterine weight but increased ovarian weight (Ceccatelli et al, 2006). The authors showed that prenatal exposure to BDE-99 disrupted the expression of estrogen target genes and their regulation by endogenous estrogens.…”

Section: Reproductive Organsmentioning

confidence: 98%

Scientific Opinion on Polybrominated Diphenyl Ethers (PBDEs) in Food

2011

EFS2

197

147

View full text Add to dashboard Cite

EFSA was asked by the European Commission to deliver a scientific opinion on polybrominated diphenyl ethers (PBDEs) in food. PBDEs are additive flame retardants which are applied in plastics, textiles, electronic castings and circuitry. PBDEs are ubiquitously present in the environment and likewise in biota and in food and feed. Data from the analysis of 19 PBDE congeners in 3,971 food samples were provided to EFSA by 11 European countries. Eight congeners were considered by the Panel on Contaminants in the Food Chain (CONTAM Panel) to be of primary interest: . The highest dietary exposure is to . Toxicity studies were carried out with technical PBDE mixtures or individual congeners. Main targets were the liver, thyroid hormone homeostasis and the reproductive and nervous system. PBDEs cause DNA damage through the induction of reactive oxygen species. The Panel identified effects on neurodevelopment as the critical endpoint, and derived benchmark doses (BMDs) and their corresponding lower 95 % confidence limit for a benchmark response of 10 %, BMDL 10 s, for a number of PBDE congeners: BDE-47, 309 μg/kg b.w.; BDE-99, 12 μg/kg b.w.; BDE-153, 83 μg/kg b.w.; BDE-209, 1,700 μg/kg b.w. Due to the limitations and uncertainties in the current database, the Panel concluded that it was inappropriate to use these BMDLs to establish health based guidance values, and instead used a margin of exposure (MOE) approach for the health risk assessment. Since elimination characteristics of PBDE congeners in animals and humans differ considerably, the Panel used the body burden as starting point for the MOE approach. The CONTAM Panel concluded that for BDE-47, -153 and -209 current dietary exposure in the EU does not raise a health concern. For BDE-99 there is a potential health concern with respect to current dietary exposure. 4 The term "intra-species" has been replaced by "inter-species" in the Summary and in Chapter 9.1. The chemical stability of the PBDE congeners varies with the individual structure. In general PBDE congeners with up to three bromine substituents and those with nine or ten bromine substituents are more sensitive to abiotic transformations. PBDE congeners with four to eight bromine substituents show the highest stability. PBDE congeners are particularly susceptible to photolysis, reductive debromination and radical reactions whereas they are less susceptible to oxidation and hydrolysis. In general, PBDE congeners are persistent and bioaccumulative with the exception of BDE-209 bioaccumulative properties of which seem to be species dependent. BDE-209 undergoes debromination reactions both in the abiotic environment and in biota, leading to formation of PBDE congeners containing seven to nine bromine atoms. © European Food SafetyBased on the composition of the technical PBDE mixtures, occurrence in the environment and in food, the Panel on Contaminants in the Food Chain (CONTAM Panel) considered the following eight PBDE congeners to be of primary interest: which are relevant for dietary PBDE exposur...

show abstract

Endocrine Disruption in Toxic Responses

Kawa

Sugihara

Nakamura

et al. 2009

General, Applied and Systems Toxicology

View full text Add to dashboard Cite

Many endocrine‐disrupting agents, including industrial materials, pesticides, pharmaceuticals and phytochemicals, have been identified with their use by in vitro assay systems and in vivo studies in laboratory animals. These chemicals are widely distributed in the environment, and are able to mimic or antagonize the biological functions of natural hormones. Indeed, abnormalities thought to be due to such agents have been found in animals throughout the world. There is also thought to be a risk to humans, for example, DES syndrome. Xenoestrogens can accumulate in our environment, and may play a role in the increasing incidences of breast cancer, testicular cancer and other problems of the reproductive system in humans. Risks due to endocrine disruptors in the environment are discussed in this chapter.

show abstract

Gene expression and estrogen sensitivity in rat uterus after developmental exposure to the polybrominated diphenylether PBDE 99 and PCB

Cited by 114 publications

References 42 publications

Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants

Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants

Scientific Opinion on Polybrominated Diphenyl Ethers (PBDEs) in Food

Endocrine Disruption in Toxic Responses

Contact Info

Product

Resources

About