2020
DOI: 10.21203/rs.3.rs-58761/v1
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Gene Expression and Regulatory Webwork of POLR2K in Bladder Carcinogenesis by Integrated Bioinformatics Approaches

Abstract: Background:RNA polymerase II subunit K (POLR2K) belongs to one of the multiple subunits of RNA polymerase II (Pol II), whose biological function is to synthesize mRNA. Aberrant POLR2K expression is related to carcinogenesis. However, POLR2K’s underlying role in bladder cancer has not been explored. In the current study, we intend to analyze the function of POLR2K and its regulatory network within bladder cancer.Methods: Public sequencing data was obtained from GEO and TCGA to investigate POLR2K expression and … Show more

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“…Finally, in bladder cancer patients, high levels of POLR2K were associated with poor progression free and overall survival. Furthermore, the knock down of the Pol II subunit reduced the viability of two bladder cancer cell lines, indicating that its decreased expression could slow down cell growth [149].…”
Section: Polr2k/rpb12mentioning
confidence: 99%
“…Finally, in bladder cancer patients, high levels of POLR2K were associated with poor progression free and overall survival. Furthermore, the knock down of the Pol II subunit reduced the viability of two bladder cancer cell lines, indicating that its decreased expression could slow down cell growth [149].…”
Section: Polr2k/rpb12mentioning
confidence: 99%