Gene expression differences in adipose tissue associated with breast tumorigenesis

Sturtz, Lori A.; Deyarmin, Brenda; Laar, Ryan K. van; Yarina, William C.; Shriver, Craig D.; Ellsworth, Rachel E.

doi:10.4161/adip.28250

Cited by 34 publications

(28 citation statements)

References 33 publications

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“…This is further supported by a study by Sturtz et al 16 that revealed an upregulated expression of genes involved in inflammation, proliferation, invasion, and migration in human adipose tissue adjacent to breast cancer, concluding adipose tissue is not inert, but plays an active fluent role in tumorigenesis. Therefore, the possible role of adipose tissue in breast tumorigenesis should be taken into consideration when planning fat grafting in a patient at increased risk for the development of breast cancer.…”

Section: The Interaction Of Ascs and Breast Cancer Cellssupporting

confidence: 61%

The Oncologic Safety of Breast Fat Grafting and Contradictions Between Basic Science and Clinical Studies

Charvet

Orbay

Wong

et al. 2015

Annals of Plastic Surgery

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Fat grafting is increasingly popular and is becoming a common practice in plastic surgery for postmastectomy breast reconstruction and aesthetic breast augmentation; however, concerns over the oncologic safety remains a controversial and hot topic among scientists and surgeons. Basic science and laboratory research repeatedly show a potentially dangerous effect of adipose-derived stem cells on breast cancer cells; however, clinical research, although limited, continually fails to show an increase in breast cancer recurrence after breast fat grafting, with the exception of 1 small study on a subset patient population with intraepithelial neoplasm of the breast. The aim of this review is to summarize the recent conflicting basic science and clinical data to better understand the safety of breast fat grafting from an oncological perspective.

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Section: The Interaction Of Ascs and Breast Cancer Cellssupporting

confidence: 61%

The Oncologic Safety of Breast Fat Grafting and Contradictions Between Basic Science and Clinical Studies

Charvet

Orbay

Wong

et al. 2015

Annals of Plastic Surgery

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“…Previous literatures have reported that RRM2 had a high expression in cancer and was involved in tumor aggressiveness, poor prognosis, and chemoresistance . For instance, Sturtz et al demonstrated that RRM2 expressed at higher levels in tumor tissues, associated with up‐regulation of cellular propagation and invasiveness . Shah et al revealed that RRM2 was overexpressed in tamoxifen‐resistant BC cells, and enhanced the proliferation and metastasis of MCF‐7 BC cells .…”

Section: Discussionmentioning

confidence: 99%

DSCAM‐AS1 promotes tumor growth of breast cancer by reducing miR‐204‐5p and up‐regulating RRM2

Liang

Yuan

et al. 2018

Molecular Carcinogenesis

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Breast cancer (BC) is a common malignancy worldwide. More than 3 700 000 women die of BC every year. DSCAM-AS1 was overexpressed several kinds of cancer and miR-204-5p was lowly expressed, which indicated that miR-204-5p had anti-tumor activity and DSCAM-AS1 had pro-tumor activity. We intended to analyze DSCAM-AS1, miR-204-5p, and ribonucleotide reductase M2 (RRM2). Microarray analysis and quantitative Real Time fluorescence Polymerase Chain Reaction (qRT-PCR) were employed to determine DSCAM-AS1 and miR-204-5p expression. Luciferase reporter assay was applied to examine the target relationship between DSCAM-AS1, miR-204-5p, and RRM2. Cell Counting Kit-8 (CCK-8 assay), transwell assay, and flow cytometry were used to detect cell proliferation, invasion, and apoptosis. The expression of DSCAM-AS1, miR-204-5p, and RRM2 were confirmed by Western blot. We also conducted in vivo assay to verify the effect of DSCAM-AS1. DSCAM-AS1 was up-regulated, while miR-204-5p was down-regulated in BC tissues and cells. DSCAM-AS1 directly targeted miR-204-5p. DSCAM-AS1 promoted the proliferation and invasion of BC cells by reducing miR-204-5p and inhibiting miR-204-5p expression. DSCAM-AS1 expression was related to the expression of RRM2, and miR-204-5p could reverse the function of DSCAM-AS1. RRM2 was up-regulated in BC cells, and miR-204-5p inhibited RRM2 expression by targeting RRM2. Overexpression of RRM2 stimulated proliferation and cell invasion and impeded apoptosis. In vivo experiments showed that knockdown of DSCAM-AS1 decreased the tumorigenesis of BC cells, increased the expression of miR-204-5p. DSCAM-AS1 promoted proliferation and impaired apoptosis of BC cells by reducing miR-204-5p and enhancing RRM2 expression. DSCAM-AS1/miR-204-5p/RRM2 may serve as novel therapeutic targets for BC. K E Y W O R D S Breast cancer, DSCAM-AS1, miR-204-5p, RRM2

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“…Increased peritoneal ovarian tumour metastatic growth was observed in obese versus control mice, in three different models of DIO, and this was correlated with enhanced vascularity and a decreased M1:M2 macrophage ratio [73]. These data suggest an altered tumour microenvironment influenced by crosstalk between peritumoural fat and tumour cells [68].…”

Section: The Tumour Microenvironment: Role Of Peritumoural Fat and Immentioning

confidence: 93%

“…Most studies are in breast cancer. Adipose tissue surrounding invasive breast cancers exhibits increased expression of antiinflammatory genes, such as those encoding macrophage receptor with collagenous structure (MARCO) and V-Set and immunoglobulin domain containing 4 (VSIG4), while genes differentially expressed between tumour-adjacent and distant adipose tissue including those encoding secreted phosphoprotein 1 (SPP1), ribonucleotide reductase M2 (RRM2), and matrix metalloproteinase 9 (MMP9), are associated with increased cellular proliferation, invasion, and angiogenesis [68]. Moreover, in prostate cancer, gene expression signatures are different in tumours from obese versus lean cohorts [69].…”

Section: The Tumour Microenvironment: Role Of Peritumoural Fat and Immentioning

confidence: 99%

Emerging Concepts Linking Obesity with the Hallmarks of Cancer

Donohoe

Lysaght

O'Sullivan

et al. 2017

Trends in Endocrinology & Metabolism

103

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Gene expression differences in adipose tissue associated with breast tumorigenesis

Cited by 34 publications

References 33 publications

The Oncologic Safety of Breast Fat Grafting and Contradictions Between Basic Science and Clinical Studies

The Oncologic Safety of Breast Fat Grafting and Contradictions Between Basic Science and Clinical Studies

DSCAM‐AS1 promotes tumor growth of breast cancer by reducing miR‐204‐5p and up‐regulating RRM2

Emerging Concepts Linking Obesity with the Hallmarks of Cancer

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