Gene Expression in Endometriosis

Joshi, Niraj; Su, Ren-Wei; Fazleabas, Asgerally T.

doi:10.1007/978-3-030-28584-5_11

Cited by 3 publications

(2 citation statements)

References 168 publications

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“…The decrease or absence of this gene results in a weak progesterone response promoting defective decidualization and implantation in humans and baboons [130]. The alteration of miR-29c resulting in the decrease of FKBP4 during the window of implantation could lead to the progesterone resistance in women with endometriosis, promoting infertility [156]. These in vivo experiments have been further characterized in vitro using HUF cells and showing a compromised decidualization response compared to positive controls [130].…”

Section: Endometriosismentioning

confidence: 99%

“…This miRNA is upregulated in endometriosis decreasing the expression of one of its targets, FK506-binding protein 4 (FKBP4) gene. FKBP4 is a co-chaperone that optimizes the function of the progesterone receptor [156]. The decrease or absence of this gene results in a weak progesterone response promoting defective decidualization and implantation in humans and baboons [130].…”

Section: Endometriosismentioning

confidence: 99%

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Physiologic Events of Embryo Implantation and Decidualization in Human and Non-Human Primates

Ochoa-Bernal

Fazleabas

2020

IJMS

157

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Reproduction is a fundamental process for the preservation of the human species. This process requires a sequence of orchestrated events that are necessary for a successful pregnancy. Two of the most critical steps in the establishment of human pregnancy are implantation and decidualization, which are required for maternal interactions with the developing embryo. This review primarily highlights the physiological aspects of these two events and the adverse pregnancy outcomes from defective implantation and decidualization. The focus of this review is to provide a general concept of the mechanisms involved during the window of implantation, description of components involved in the process and possible pathologies that could disrupt the embryo implantation and decidualization and specifically as it applies to women and non-human primates.

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Section: Endometriosismentioning

confidence: 99%

Section: Endometriosismentioning

confidence: 99%

Physiologic Events of Embryo Implantation and Decidualization in Human and Non-Human Primates

Ochoa-Bernal

Fazleabas

2020

IJMS

157

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Establishment of an Immortalized Endometriotic Stromal Cell Line from Human Ovarian Endometrioma

et al. 2020

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Endometrial-like stromal cells, one of the main components of endometriotic lesions, are an important in vitro model for studying cellular and molecular mechanisms associated with lesion development in endometriosis. However, the short life span of primary endometriotic stromal cells (Ec-ESC) limit their use. Human telomerase reverse transcriptase (hTERT) plasmids can be used to develop immortalized cell lines. Here we aimed to establish an endometriotic stromal cell line by hTERT immortalization. Primary Ec-ESC were obtained from a human ovarian endometriotic cyst. The purity was assessed by morphology and the expression of vimentin, cytokeratin, and human interferon-inducible transmembrane protein 1 (hIFITM1). Cells were infected with hTERT lentiviral vector and selected with hygromycin. hTERT mRNA levels were confirmed by RT-qPCR. Immortalized Ec-ESC (iEc-ESC) were characterized by examining the expression of morphological markers and key genes of interest, TP53, estrogen receptor β (ERβ), progesterone receptor (PR) and steroidogenic factor-1 (SF-1). Karyotyping and in vitro decidualization studies were also performed. Ec-ESCs were positive for vimentin and hIFITM1 and negative for Terms of use and reuse: academic research for non-commercial purposes, see here for full terms.

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LipGene: Lipschitz Continuity Guided Adaptive Learning Rates for Fast Convergence on Microarray Expression Data Sets

Prashanth¹,

Saha²,

Basarkod³

et al. 2022

IEEE/ACM Trans. Comput. Biol. and Bioinf.

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Gene Expression in Endometriosis

Cited by 3 publications

References 168 publications

Physiologic Events of Embryo Implantation and Decidualization in Human and Non-Human Primates

Physiologic Events of Embryo Implantation and Decidualization in Human and Non-Human Primates

Establishment of an Immortalized Endometriotic Stromal Cell Line from Human Ovarian Endometrioma

LipGene: Lipschitz Continuity Guided Adaptive Learning Rates for Fast Convergence on Microarray Expression Data Sets

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