Gene Expression of Tyrosine Hydroxylase in the Developing Fetal Brain

Coulon, J.F.; Biguet, Nicole Faucon; Cavoy, Albert; Delacour, Jean; Mallet, Jacques; David, Jean‐Claude

doi:10.1111/j.1471-4159.1990.tb03154.x

Cited by 21 publications

(5 citation statements)

References 37 publications

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“…(for background discussion, see Puelles and Medina, 1994). Recent expression data on genes that relate directly or indirectly to catecholamine synthesizing cells (Burgunder and Young, 1990;Coulon et al, 1990;Weiss-Wunder and Chesselet, 1991;Solberg et al, 1993;Valarché et al, 1993;Son et al, 1996;Livesey and Hunt, 1997;Zetterström et al, 1997) and progress with in vitro or transgenic experimental approaches (Yamada et al, 1991;Echelard et al, 1993;Ericson et al, 1995;Hynes et al, 1995a,b;Kobayashi et al, 1995;Thomas et al, 1995;Zhou et al, 1995;Perrone-Capano and Di Porzio, 1996) have increased considerably the potential for such causal explanations. Puelles and Medina (1994) examined the neural tube topology of catecholamine primordia in avian embryos and compared them with extant data on mammalian, reptilian, and amphibian embryos.…”

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confidence: 97%

Early neuromeric distribution of tyrosine-hydroxylase-immunoreactive neurons in human embryos

1998

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A segmental mapping of brain tyrosine-hydroxylase-immunoreactive (TH-IR) neurons in human embryos between 4.5 and 6 weeks of gestation locates with novel precision the dorsoventral and anteroposterior topography of the catecholamine-synthetizing primordia relative to neuromeric units. The data support the following conclusions. (1) All transverse sectors of the brain (prosomeres in the forebrain, midbrain, rhombomeres in the hindbrain, spinal cord) produce TH-IR neuronal populations. (2) Each segment shows peculiarities in its contribution to the catecholamine system, but there are some overall regularities, which reflect that some TH-IR populations develop similarly in different segments. (3) Dorsoventral topology of the TH-IR neurons indicates that at least four separate longitudinal zones (in the floor and basal plates and twice in the alar plate) found across most segments are capable of producing the TH-IR phenotype. (4) Basal plate TH-IR neurons tend to migrate intrasegmentally to a ventrolateral superficial position, although some remain periventricular; those in the brainstem are related to motoneurons of the oculomotor and branchiomotor nuclei. (5) Some alar TH-IR populations migrate superficially within the segmental boundaries. (6) Most catecholaminergic anatomical entities are formed as fusions of smaller segmental components, each of which show similar histogenetic patterns. A nomenclature is proposed that partly adheres to previous terminology but introduces the distinction of embryologically different cell populations and unifies longitudinally analogous entities. Such a model, as presented in the present study, is convenient for resolving problems of homology of the catecholamine system across the diversity of vertebrate forms.

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confidence: 97%

Early neuromeric distribution of tyrosine-hydroxylase-immunoreactive neurons in human embryos

1998

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“…Tyrosine hydrolase mRNA was lowest in neonates and, with development, an increase in the quantity of TH mRNA, was seen although patterns were different among neonates with pathalogic lesions. 22 In our immunohistochemical study of development ranging from fetuses to adults, localization and appearance of T H changed with increasing age. In the mid-brain, positive neurons were found in the substantia nigra and around the red nucleus.…”

Section: Discussionmentioning

confidence: 79%

“…Developmental TH-expression of neurons was studied in fetal rats by Coulon et a1., 22 and in postnatal rats by Kedzierski and Porter.23 The latter group quantitatively studied T H mRNA in catecholaminergic cells of the substantia nigra, hypothalamus, superior cervical ganglion, and adrenal gland from early neonatal life to old age. Tyrosine hydrolase mRNA was lowest in neonates and, with development, an increase in the quantity of TH mRNA, was seen although patterns were different among neonates with pathalogic lesions.…”

Section: Discussionmentioning

confidence: 99%

Neuropathology and immunohistochemistry of the brain‐stem in neonates with congenital hydrocephalus: Comparative studies between aqueductal stenosis and Arnold‐Chiari malformation

Fukumizu

Takashima

Becker

1994

Pediatrics International

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Neuropathological and immunohistochemical studies were done on the brain‐stem of neonates who had congenital hydrocephalus with aqueductal stenosis or Arnold‐Chiari malformation (ACM). The infants with aqueductal stenosis showed heterogeneity in their clinicopathological findings while the infants with ACM were relatively similar in neuropathological findings. There were prominent astrogliosis, decreased immunoreactivity with antisera to tyrosine hydroxylase and myelin basic protein in the periaqueductal area, and an increased reactivity with antiserum to substance P in the tegmentum of most patients with aqueductal stenosis and other malformations. In ACM, there was little gliosis in the tegmentum and periaqueductal area and minimal immunoreactivity of tyrosine hydroxylase, myelin basic protein and substance P. In both groups of cases, the cells in the periaqueductal region differ in neurotransmitter/neuromodulator immunoreactivity and degree of myelination reflecting a difference possibly in their maldevelopment.

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“…The CA is involved in the control of autonomic and neuroendocrine functions as well as several behavioral patterns including stress reactions. TH mRNA was produced in the whole rat brain from 13 days of gestation, but the largest increase of the expression was observed in the hypothalamus (10). TH mRNA was mostly expressed in the olfactory and hypothalamic areas, whereas sparse TH expression was observed in the telencephalic region and brainstem (11).…”

Section: Reprintsmentioning

confidence: 98%

EFFECT OF DIAZINON ON BEHAVIOR OF JAPANESE MEDAKA (ORYZIAS LATIPES) AND GENE EXPRESSION OF TYROSINE HYDROXYLASE AS A BIOMARKER

Shin

Chung

Kim

et al. 2001

Journal of Environmental Science and Health, Part B

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This paper reports on the development of a biomarker used to monitor abnormal behaviors caused by diazinon in Japanese medaka (Oryzias latipes) as a model organism. Tyrosine hydroxylase (TH) activity in tissues was measured and the TH enzyme production in specific organs using a in situ cytochemical technique was monitored. These data were comparatively analyzed with those from semi-quantitative RT-PCR utilizing medaka TH gene that could be a potential biomarker for neuronal modulations and behaviors. For monitoring experiments at behavioral and molecular biological levels, the fish were treated under different sublethal conditions of diazinon (O, O-diethyl O-[6-methyl-2-(1-methylethyl)-4-pyrimidinyl] phosphorothioate) and their behavioral responses were observed. There were no significant differences in activity of TH head and body portions when the fish were exposed to lower concentrations (0.5-10 ppb) of diazinon including control treatment (0 ppb) for 24 hr. In temporal change of TH activity at 100 ppb diazinon treatment, however, the activity of body portion appeared to be inhibited during the first 30 min exposure but later seemed to recover slightly after 1 hr. TH appeared to be expressed mainly in the olfactory bulb, midbrain and brain stem regions as assessed by in situ immunohistochemistry. The treatment (1000 ppb) significantly suppressed TH protein production in the olfactory bulb, midbrain and brain stem regions. In kidney from the body portion the higher concentration treatment (1000 ppb) caused little suppression compared with the control. The RT-PCR showed that a production of TH mRNA transcript was significantly inhibited at 5 ppm diazinon treatment in the body portion. It was concluded that a suppression of TH activity would be one of the causes for the abnormal behaviors of the medaka that could be quantitatively monitored using an image processing system. This study provides molecular and neurobehavioral bases of a biomonitoring system for toxic chemicals using a model organism such as fish.

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Gene Expression of Tyrosine Hydroxylase in the Developing Fetal Brain

Cited by 21 publications

References 37 publications

Early neuromeric distribution of tyrosine-hydroxylase-immunoreactive neurons in human embryos

Early neuromeric distribution of tyrosine-hydroxylase-immunoreactive neurons in human embryos

Neuropathology and immunohistochemistry of the brain‐stem in neonates with congenital hydrocephalus: Comparative studies between aqueductal stenosis and Arnold‐Chiari malformation

EFFECT OF DIAZINON ON BEHAVIOR OF JAPANESE MEDAKA (ORYZIAS LATIPES) AND GENE EXPRESSION OF TYROSINE HYDROXYLASE AS A BIOMARKER

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