Gene expression of vasoactive intestinal peptide receptors in human lung cancer

Szilasi, Mária; Buglyo, Armin; Treszl, Andrea; Kiss, Lili; Schally, Andrew V.; Halmos, Gábor

doi:10.3892/ijo.2011.1122

Cited by 10 publications

(5 citation statements)

References 29 publications

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“…The vasoactive intestinal peptide receptor-1 (VIPR1) has an important neuropeptide that controls lung physiology and main functions. VIP antagonist in vitro inhibits the proliferation of NSCLC and reduces the growth of NSCLC tumors transplanted into nude mice [ 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of Prognostic Immune-Related Genes by Integrating mRNA Expression and Methylation in Lung Adenocarcinoma

Zhu

Wang

2020

International Journal of Genomics

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Background. There is plenty of evidence showing that immune-related genes (IRGs) and epigenetic modifications play important roles in the biological process of cancer. The purpose of this study is to establish novel IRG prognostic markers by integrating mRNA expression and methylation in lung adenocarcinoma (LUAD). Methods and Results. The transcriptome profiling data and the RNA-seq data of LUAD with the corresponding clinical information of 543 LUAD cases were downloaded from The Cancer Genome Atlas (TCGA) database, which were analyzed by univariate Cox proportional regression and multivariate Cox proportional regression to develop an independent prognostic signature. On the basis of this signature, we could divide LUAD patients into the high-risk, medium-risk, and low-risk groups. Further survival analyses demonstrated that high-risk patients had significantly shorter overall survival (OS) than low-risk patients. The signature, which contains 8 IRGs (S100A16, FGF2, IGKV4-1, CX3CR1, INHA, ANGPTL4, TNFRSF11A, and VIPR1), was also validated by data from the Gene Expression Omnibus (GEO) database. We also conducted analyses of methylation levels of the relevant IRGs and their CpG sites. Meanwhile, their associations with prognosis were examined and validated by the GEO database, revealing that the methylation levels of INHA, S100A16, the CpG site cg23851011, and the CpG site cg06552037 may be used as the potential regulators for the treatment of LUAD. Conclusion. Collectively, INHA, S100A16, the CpG site cg23851011, and the CpG site cg06552037 are promising biomarkers for monitoring the outcomes of LUAD.

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Section: Discussionmentioning

confidence: 99%

Identification of Prognostic Immune-Related Genes by Integrating mRNA Expression and Methylation in Lung Adenocarcinoma

Zhu

Wang

2020

International Journal of Genomics

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“…VPAC1/VPAC2 mRNA is found 51% and 48% of lung-cancer surgical specimens[48]. A number of recent basic-science and animal-studies provide insights into the signaling-cascades and effects of VIP on lung-cancer-cells, that may yield therapeutic approaches.…”

Section: Vip/pacap: Lung-cancermentioning

confidence: 99%

“…VIP-immunoreactivity(VIP-IR) occurs in a number of tumors[45•] and VPAC1 is overexpressed, resulting in high densities, in numerous cancers including bladder, breast, colon, liver, lung, pancreatic, prostate, thyroid and uterus- cancer[39, 45•, 46, 47••, 48]. In contrast, VPAC2 has been less well-studied, but is present in gastric leiomyomas; thyroid, gastric/pancreatic adenocarcinomas; lung-tumors, various sarcomas and neuroendocrine-tumors[46, 48-50].…”

Section: Introductionmentioning

confidence: 99%

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Vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide, and their receptors and cancer

Moody¹,

Nuche-Berenguer

Jensen

2016

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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Purpose of review To summarize the roles of VIP/PACAP and their receptors(VPAC1, VPAC2/PAC1) in human tumors as well as their role in potential novel treatments. Recent findings Considerable progress has been made in understanding of the effects of VIP/PACAP on growth of various tumors as well as in the signaling cascades involved, especially of the role of transactivation of the Epidermal growth factor(EGF) family. The overexpression of VPAC1/2, PAC1 on a number of common neoplasms (breast, lung, prostate, CNS, neuroblastoma) is receiving increased attention both as a means of tumor imaging the location and extent of these tumors, as well as for targeted directed treatment, by coupling cytotoxic agents to VIP/PACAP analogues. Summary VIP/PACAP has prominent growth effects on a number of common neoplasms, which frequently overexpressed the three subtypes of their receptors. The increased understanding of their signaling cascades, effect on tumor growth/differentiation, and the use of the overexpression of these receptors for localization/targeted cytotoxic delivery, are all suggesting possible novel tumor treatments.

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“…This type 2 receptor is expressed in the central nervous system, smooth muscle and blood vessels [17,18]. VPAC2 has been poorly studied in cancer, but it has been detected in thyroid, gastric, lung and neuroendocrine tumours, among others [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Colorectal Cancer Early Detection in Stool Samples Tracing CpG Islands Methylation Alterations Affecting Gene Expression

Vega-Benedetti

Loi

Moi

et al. 2020

IJMS

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Colorectal cancer (CRC) is a major cause of cancer mortality. Early diagnosis is relevant for its prevention and treatment. Since DNA methylation alterations are early events in tumourigenesis and can be detected in cell-free DNA, they represent promising biomarkers for early CRC diagnosis through non-invasive methods. In our previous work, we identified 74 early altered CpG islands (CGIs) associated with genes involved in cell cross-talking and cell signalling pathways. The aim of this work was to test whether methylation-based biomarkers could be detected in non-invasive matrices. Our results confirmed methylation alterations of GRIA4 and VIPR2 in CRC tissues, using MethyLight, as well as in stool samples, using a much more sensitive technique as droplet digital PCR. Furthermore, we analysed expression levels of selected genes whose promoter CGIs were hypermethylated in CRC, detecting downregulation at mRNA and protein levels in CRC tissue for GRIA4, VIPR2, SPOCK1 and SLC6A3. Most of these genes were already lowly expressed in colon normal tissues supporting the idea that cancer DNA methylation targets genes already barely expressed in the matched normal tissues. Our study suggests GRIA4 and VIPR2 as biomarkers for early CRC diagnosis using stool samples and confirms downregulation of genes hypermethylated in CRC.

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Gene expression of vasoactive intestinal peptide receptors in human lung cancer

Cited by 10 publications

References 29 publications

Identification of Prognostic Immune-Related Genes by Integrating mRNA Expression and Methylation in Lung Adenocarcinoma

Identification of Prognostic Immune-Related Genes by Integrating mRNA Expression and Methylation in Lung Adenocarcinoma

Vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide, and their receptors and cancer

Colorectal Cancer Early Detection in Stool Samples Tracing CpG Islands Methylation Alterations Affecting Gene Expression

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