Gene Expression Profile of the Rat Eye Iridocorneal Angle: NEIBank Expressed Sequence Tag Analysis

Abstract

The iridocorneal libraries are a good source of novel uncharacterized genes and molecular markers for the tissues of the eye angle. Although myocilin is not abundantly expressed in rat eye angle, other olfactomedin-containing genes are expressed there and may play important roles in normal eye function and disease.

Expression of Mutated Mouse Myocilin Induces Open-Angle Glaucoma in Transgenic Mice

“…Increased Myoc in Tg TM was associated with a decrease in ATPase-1, which is highly expressed in the eye angle (Ahmed et al, 2004). A decrease in Na ϩ gradient may result in several harmful events including cell overloading with calcium attributable to reversal of Na ϩ /Ca 2ϩ exchanger (Senatorov et al, 2000).…”

Functional rescue of experimental ischemic optic neuropathy with αB-crystallin

“…39 In the absence of aBC, retinal pigment epithelium is more susceptible to H 2 O 2 -induced apoptosis 37 and exhibits greater post-ischemic inflammatory changes at the ON head, supporting aBC's role as a negative regulator of inflammation (this report). In contrast, progressive RGC degeneration observed in the ocular hypertension rat model for glaucomatous neuropathy is associated with a temporary downregulation of aBC after 2 weeks and recovery after 5 weeks, [31][32][33] suggesting a transient negative effect of ocular hypertension on aBC gene expression. 32 The improvement in fVEPs responses following aBC treatment developed over 3 weeks, during a period of known axonal and oligodendrocyte loss.…”

Novel genetic variants modify the effect of smoking on carotid plaque burden in Hispanics

“…We just know that its homologous in rat plays important roles in maintaining normal eye function and disease [30]. Further studies are needed to clarify the role of the protein encoded by this gene in human physiology and pathology.…”