Gene expression profiles of diabetic mice treated with whole body hyperthermia: A high-density DNA microarray analysis

Kokura, Satoshi; Adachi, Satoko; Mizushima, Katsura; Okayama, Tetsuya; Hattori, Takeshi; Okuda, Tomohiro; Nakabe, Nami; Manabe, Emiko; Ishikawa, Takeshi; Handa, Osamu; Takagi, Tomohisa; Naito, Yuji; Yoshikawa, Toshikazu

doi:10.3109/02656730903272917

Cited by 8 publications

(4 citation statements)

References 27 publications

(35 reference statements)

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“…Similarly, diabetic rats have an increased mortality rate when exposed to severe heat, and exogenous insulin increases their survival time (Niu et al, 2003). Furthermore, nonlethal heat stress ameliorates proxies of insulin insensitivity in diabetic rodents (Kokura et al, 2007(Kokura et al, , 2010 or rodents fed high fat diets (Gupte et al, 2009). This is similar to reports indicating that thermal therapy (e.g., saunas and hot baths) improves insulin sensitivity in humans (McCarty et al, 2009).…”

Section: Insulinsupporting

confidence: 74%

RUMINANT NUTRITION SYMPOSIUM: Ruminant Production and Metabolic Responses to Heat Stress1,2

Baumgard

Rhoads

2012

Journal of Animal Science

191

127

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Heat stress compromises efficient animal production by marginalizing nutrition, management, and genetic selection efforts to maximize performance endpoints. Modifying farm infrastructure has yielded modest success in mitigating heat stress-related losses, yet poor production during the summer remains arguably the costliest issue facing livestock producers. Reduced output (e.g., milk yield and muscle growth) during heat stress was traditionally thought to result from decreased nutrient intake (i.e., a classic biological response shared by all animals during environmental-induced hyperthermia). Our recent observations have begun to challenge this belief and indicate heat-stressed animals employ novel homeorhetic strategies to direct metabolic and fuel selection priorities independently of nutrient intake or energy balance. Alterations in systemic physiology support a shift in carbohydrate metabolism, evident by increased basal and stimulated circulating insulin concentrations. Perhaps most intriguing given the energetic shortfall of the heat-stressed animal is the apparent lack of basal adipose tissue mobilization coupled with a reduced responsiveness to lipolytic stimuli. Thus, the heat stress response markedly alters postabsorptive carbohydrate, lipid, and protein metabolism independently of reduced feed intake through coordinated changes in fuel supply and utilization by multiple tissues. Interestingly, the systemic, cellular, and molecular changes appear conserved amongst different species and physiological states. Ultimately, these changes result in the reprioritization of fuel selection during heat stress, which appears to be primarily responsible for reduced ruminant animal productivity during the warm summer months.

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Section: Insulinsupporting

confidence: 74%

RUMINANT NUTRITION SYMPOSIUM: Ruminant Production and Metabolic Responses to Heat Stress1,2

Baumgard

Rhoads

2012

Journal of Animal Science

191

127

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“…Similarly, diabetic rats have an increased mortality rate when exposed to severe heat, and exogenous insulin increases their survival time (142). Furthermore, nonlethal heat stress ameliorates proxies of insulin insensitivity in diabetic rodents (143,144) or rodents fed high-fat diets (145). This is similar to reports indicating that thermal therapy (saunas and hot baths) improves insulin sensitivity in humans (146).…”

Section: Systemic Heat Stress Responsesupporting

confidence: 67%

Nutritional Interventions to Alleviate the Negative Consequences of Heat Stress

Rhoads

Baumgard

Suagee

et al. 2013

Advances in Nutrition

192

135

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Energy metabolism is a highly coordinated process, and preferred fuel(s) differ among tissues. The hierarchy of substrate use can be affected by physiological status and environmental factors including high ambient temperature. Unabated heat eventually overwhelms homeothermic mechanisms resulting in heat stress, which compromises animal health, farm animal production, and human performance. Various aspects of heat stress physiology have been extensively studied, yet a clear understanding of the metabolic changes occurring at the cellular, tissue, and whole-body levels in response to an environmental heat load remains ill-defined. For reasons not yet clarified, circulating nonesterified fatty acid levels are reduced during heat stress, even in the presence of elevated stress hormones (epinephrine, glucagon, and cortisol), and heat-stressed animals often have a blunted lipolytic response to catabolic signals. Either directly because of or in coordination with this, animals experiencing environmental hyperthermia exhibit a shift toward carbohydrate use. These metabolic alterations occur coincident with increased circulating basal and stimulated plasma insulin concentrations. Limited data indicate that proper insulin action is necessary to effectively mount a response to heat stress and minimize heat-induced damage. Consistent with this idea, nutritional interventions targeting increased insulin action may improve tolerance and productivity during heat stress. Further research is warranted to uncover the effects of heat on parameters associated with energy metabolism so that more appropriate and effective treatment methodologies can be designed.

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“…(2009) reported that thermal therapy can improve insulin sensitivity in humans. Moreover, HS can ameliorate biomarkers of insulin sensitivity in diabetic rats ( Kokura et al., 2010 ) and rats fed a high-fat diet ( Gupte et al., 2009 ). Increased insulin sensitivity may be an essential component of the acclimation mechanism in HS.…”

Section: Discussionmentioning

confidence: 99%

Nano-chromium picolinate and heat stress enhance insulin sensitivity in cross-bred sheep

et al. 2023

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Gene expression profiles of diabetic mice treated with whole body hyperthermia: A high-density DNA microarray analysis

Cited by 8 publications

References 27 publications

RUMINANT NUTRITION SYMPOSIUM: Ruminant Production and Metabolic Responses to Heat Stress1,2

RUMINANT NUTRITION SYMPOSIUM: Ruminant Production and Metabolic Responses to Heat Stress1,2

Nutritional Interventions to Alleviate the Negative Consequences of Heat Stress

Nano-chromium picolinate and heat stress enhance insulin sensitivity in cross-bred sheep

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