Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms

Hoffman, Matthew P.; Kidder, Benjamin L.; Steinberg, Zachary L.; Lakhani, Saba; Ho, Susan; Kleinman, Hynda K.; Larsen, Melinda

doi:10.1242/dev.00172

Cited by 198 publications

(237 citation statements)

References 69 publications

Supporting

Mentioning

222

Contrasting

Unclassified

Order By: Relevance

“…BMP suppresses branching morphogenesis induced by FGF during organogenesis of the lung, kidney, and salivary gland (Weaver et al, 2000;Hoffman et al, 2002;Bush et al, 2004). Thus, we investigated whether BMP would also suppress the morphogenesis of the hepatic epithelium induced by FGF.…”

Section: (E J) Rcas-fgfr3ca Infection Inducedmentioning

confidence: 98%

“…2). FGF7 has been reported to induce the expression of Fgfr1b in the branching processes of the mouse submandibular gland in vitro (Hoffman et al, 2002;Steinberg et al 2005), suggesting that bFGF administration to the hepatic epithelium in vitro could increase the transcription of Fgfr1 and Fgfr2. To verify this possibility, we analyzed the expression of Fgfr1 or Fgfr2 by semi-quantitative RT-PCR in the hepatic epithelium cultured in the presence and absence of bFGF.…”

Section: Bfgf Promotes the Expressions Of Fgfr1 And Fgfr2 In Vitromentioning

confidence: 99%

See 1 more Smart Citation

FGF signaling segregates biliary cell‐lineage from chick hepatoblasts cooperatively with BMP4 and ECM components in vitro

Yanai

Tatsumi

Hasunuma

et al. 2008

Developmental Dynamics

View full text Add to dashboard Cite

Intrahepatic bile ducts (IHBDs) are indispensable for transporting bile secreted from hepatocytes to the hepatic duct. The biliary epithelial cells (BECs) of the IHBD arise from bipotent hepatoblasts around the portal vein, suggesting the portal mesenchyme is essential for their development. However, except for Notch or Activin/ TGF-␤ signaling molecules, it is not known which molecules regulate IHBD development. Here, we found that FGF receptors and BMP4 are specifically expressed in the developing IHBD and the hepatic mesenchyme, respectively. Using a mesenchyme-free culture of liver bud, we showed that bFGF and FGF7 induce the hepatoblasts to differentiate into BECs, and that BMP4 enhances bFGF-induced BEC differentiation. The extracellular matrix (ECM) components in the hepatic mesenchyme induced BEC differentiation. Forced expression of a constitutively active form of the FGF receptor partially induced BEC differentiation markers in vivo. These data strongly suggest that bFGF and FGF7 promote BEC differentiation cooperatively with BMP4 and ECMs in vivo.

show abstract

Section: (E J) Rcas-fgfr3ca Infection Inducedmentioning

confidence: 98%

Section: Bfgf Promotes the Expressions Of Fgfr1 And Fgfr2 In Vitromentioning

confidence: 99%

FGF signaling segregates biliary cell‐lineage from chick hepatoblasts cooperatively with BMP4 and ECM components in vitro

Yanai

Tatsumi

Hasunuma

et al. 2008

Developmental Dynamics

View full text Add to dashboard Cite

show abstract

“…FGFR1, which belongs to a family of four receptor tyrosine kinases, is a 92 kDa transmembrane protein with an extracellular domain containing three immunoglobulin-like C2-type domains, a heparin-binding site, a transmembrane domain and an intracellular thyrosine kinase domain (Eswarakumar et al, 2005). FGFR1 is expressed in most tissues including normal fetal and adult salivary gland tissue (Hughes, 1997;Hoffman et al, 2002). Interestingly, FGFR1 is also involved in the development of salivary glands by regulation of branching morphogenesis (Hoffman et al, 2002).…”

Section: Fgfr1-plag1 Gene Fusion and Amplification F Persson Et Almentioning

confidence: 99%

“…FGFR1 is expressed in most tissues including normal fetal and adult salivary gland tissue (Hughes, 1997;Hoffman et al, 2002). Interestingly, FGFR1 is also involved in the development of salivary glands by regulation of branching morphogenesis (Hoffman et al, 2002).…”

Section: Fgfr1-plag1 Gene Fusion and Amplification F Persson Et Almentioning

confidence: 99%

High-resolution array CGH analysis of salivary gland tumors reveals fusion and amplification of the FGFR1 and PLAG1 genes in ring chromosomes

et al. 2007

View full text Add to dashboard Cite

We have previously identified a subgroup of pleomorphic salivary gland adenomas with ring chromosomes of uncertain derivation. Here, we have used spectral karyotyping (SKY), fluorescence in situ hybridization (FISH) and high-resolution oligonucleotide array-CGH to determine the origin and content of these rings and to identify genes disrupted as a result of ring formation. Of 16 tumors with rings, 11 were derived from chromosome 8, 3 from chromosome 5 and 1 each from chromosomes 1, 6 and 9. Array-CGH revealed that 10/11 r(8) consisted of amplification of a 19 Mb pericentromeric segment with recurrent breakpoints in FGFR1 in 8p12 and in PLAG1 in 8q12.1. Molecular analyses revealed that ring formation consistently generated novel FGFR1-PLAG1 gene fusions in which the 5 0 -part of FGFR1 is linked to the coding sequence of PLAG1. An alternative mechanism of PLAG1 activation was found in tumors with copy number gain of an intact PLAG1 gene. Rings derived from chromosomes 1, 5, 6 or 9 did not result in gene fusions, but rather resulted in losses indicative of the involvement of putative tumor suppressor genes on 8p, 5p, 5q and/or 6q. Our findings also reveal a novel mechanism by which FGFR1 contributes to oncogenesis and further illustrate the versatility of the FGFR1 and PLAG1 genes in tumorigenesis.

show abstract

“…In ex vivo cultured SMG, branching morphogenesis involves both FGFR signaling (Morita and Nogawa, 1999; Hoffman et al , 2002; Jaskoll et al , 2002) and EGFR signaling (Kashimata and Gresik, 1997; Kashimata et al , 2000; Umeda et al , 2001). Transgenic mice lacking FGF8 (Daphna-Iken et al , 1998), FGF10 (Ohuchi et al , 2000), FGFR2b (De Moerlooze et al , 2000), or EGFR (Jaskoll and Melnick, 1999) do not develop past the initial bud stage ( Fgf8 -conditional null mice, Fgf10 -null, and FGFR2b -null mice), or they have substantially fewer terminal buds ( EGFR -null mice).…”

Section: Morphogenetic Roles Of Growth Factorsmentioning

confidence: 99%

Salivary Gland Branching Morphogenesis — Recent Progress and Future Opportunities

Hsu

Yamada

2010

Int J Oral Sci

View full text Add to dashboard Cite

Salivary glands provide saliva to maintain oral health, and a loss of salivary gland function substantially decreases quality-of-life. Understanding the biological mechanisms that generate salivary glands during embryonic development may identify novel ways to regenerate function or design artificial salivary glands. This review article summarizes current research on the process of branching morphogenesis of salivary glands, which creates gland structure during development. We highlight exciting new advances and opportunities in studies of cell-cell interactions, mechanical forces, growth factors, and gene expression patterns to improve our understanding of this important process.

show abstract

Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms

Cited by 198 publications

References 69 publications

FGF signaling segregates biliary cell‐lineage from chick hepatoblasts cooperatively with BMP4 and ECM components in vitro

FGF signaling segregates biliary cell‐lineage from chick hepatoblasts cooperatively with BMP4 and ECM components in vitro

High-resolution array CGH analysis of salivary gland tumors reveals fusion and amplification of the FGFR1 and PLAG1 genes in ring chromosomes

Salivary Gland Branching Morphogenesis — Recent Progress and Future Opportunities

Contact Info

Product

Resources

About