Gene Expression Profiling of Nasal Polyps Associated With Chronic Sinusitis and Aspirin‐Sensitive Asthma

Abstract

Nasal polyps appear to have characteristic transcriptional signatures compared to normal sinonasal mucosa. The five genes identified in this study likely play roles in the pathogenesis of polyps associated with CRS and ASA, and are therefore attractive targets for novel medical therapies for these common debilitating diseases.

Cytokines in Chronic Rhinosinusitis. Role in Eosinophilia and Aspirin-exacerbated Respiratory Disease

“…Principal component analysis using a large panel of markers could not distinguish between NP of AERD and CRSwNP; this finding is consistent with other large microarray-based studies in which researchers investigated differences in various sinonasal tissues (38,39). However, some significant differences between the two polyp subtypes were identified upon a more focused analysis of specific mediators.…”

Periostin and receptor activator of nuclear factor κ‐B ligand expression in allergic fungal rhinosinusitis

“…Using polymerase chain reaction (PCR) and immunohistochemistry techniques, periostin levels were found to be significantly elevated in polypoid tissue in patients with CRS and nasal polyposis with and without aspirin sensitivity when compared with controls. 9 These increased periostin levels were found to be specific to the polypoid tissue sample itself and not universally elevated in samples of adjacent "healthy" mucosa from the same patient. 10 However, despite periostin's significant role in Th-2-mediated pathways, eosinophil recruitment, mucus production, and sinonasal inflammatory disease, it has yet to be evaluated in patients with AFRS.…”

Single-Nucleotide Polymorphisms on theRYD5Gene in Nasal Polyposis

“…NP is a chronic inflammatory disease (Van Zele et al, 2006;Stankovic et al, 2008;Fokkens et al, 2012). It has been known that the cytokine-driven regulation of expression in the SCGB superfamily in the airways plays a role in the pathogenesis of some diseases, such as asthma, rhinitis, and NP (Dear et al, 1991;Mukherjee et al, 1999;Jackson et al, 2011;Lu et al, 2011;Pala et al, 2014).…”

“…The prevalence of NP in the general population has been estimated as 1-4%, although evidence is insufficient (Fokkens et al, 2012). NP is a multifactorial disease and its etiopathogenesis has been known to be associated with conditions such as allergic rhinitis, allergy, asthma, and aspirin intolerance (Van Zele et al, 2006;Stankovic et al, 2008).…”