2005
DOI: 10.1016/j.tox.2005.07.008
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Gene expression profiling of responses to dimethylarsinic acid in female F344 rat urothelium

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Cited by 27 publications
(15 citation statements)
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“…The utility of gene expression profiling in hazard identification has been examined for a limited number of chemicals, including dibutyl phthalate and acetaminophen (Euling et al, 2011;Kienhuis et al, 2011;Makris et al, 2010). Toxicogenomic profiles of alachlor exposure in rat olfactory mucosa (Genter et al, 2002) and dimethylarsenic (DMA) exposure in human cultured bladder cells and rat bladder epithelium (Sen et al, 2005; US EPA, 2005) have also Table 3 Comparison of CBNP profiles with lung disease models using functional analysis for genes in common (grey) and genes unique to CBNP (black). provided useful information for two final assessments of acetochlor and arsenicals (US EPA, 2004.…”
Section: Hazard Identification Mode Of Action and Prediction Of Apicmentioning
confidence: 99%
“…The utility of gene expression profiling in hazard identification has been examined for a limited number of chemicals, including dibutyl phthalate and acetaminophen (Euling et al, 2011;Kienhuis et al, 2011;Makris et al, 2010). Toxicogenomic profiles of alachlor exposure in rat olfactory mucosa (Genter et al, 2002) and dimethylarsenic (DMA) exposure in human cultured bladder cells and rat bladder epithelium (Sen et al, 2005; US EPA, 2005) have also Table 3 Comparison of CBNP profiles with lung disease models using functional analysis for genes in common (grey) and genes unique to CBNP (black). provided useful information for two final assessments of acetochlor and arsenicals (US EPA, 2004.…”
Section: Hazard Identification Mode Of Action and Prediction Of Apicmentioning
confidence: 99%
“…Previous microarray studies on arsenic were mainly performed in vitro using human or murine cell lines (4,6,21,22,45,64,66,67) and yeast (29), while in vivo studies typically involved chronic exposure to arsenic (37,62,63). A recent study investigated subacute in vivo effects of dimethylarsinic acid on gene expression profiles of rat urothelium (48). Although many arsenic-induced, differentially expressed genes have been identified, there are no data on in vivo kinetics evaluated by the microarray approach on the adaptive response of a specific targeted organ, such as liver; undoubtedly, these data from microarray analyses should aid further understanding of arsenic mechanisms of toxicity resulting in pathology.…”
mentioning
confidence: 99%
“…We found that the number of genes altered by diuron after 7 days of exposure followed a dose-response relationship, although no significant morphological lesions were observed in any diuron treatment group using LM and only a minimal response was seen under SEM. Other studies that have investigated dose-response effects of toxicants using integrated transcriptomics and classic toxicological endpoints have also reported that transcriptional changes may be observed in the absence of morphological or clinical manifestations (Sen et al, 2005;Nesnow et al, 2009;Ludwig et al, 2011). Unsupervised analysis (PCA) revealed that the gene expression profile of the 2500 ppm group was clearly separated from the profiles of other dose levels, indicating that even after 7 days the carcinogenic dose elicited a transcriptional response that was distinguishable from the other doses.…”
Section: Discussionmentioning
confidence: 99%