Gene Expression Profiling Reveals Upregulated <i>UCA1</i> and <i>BMF</i> in Gallbladder Epithelia of Children With Pancreaticobiliary Maljunction

Kaneko, Kenitiro; Ito, Yoshinori; Ono, Yoshio; Tainaka, Takahisa; Tsuchiya, Hironori; Shimoyama, Yoshie; Ando, Hisami

doi:10.1097/mpg.0b013e318214bd30

Cited by 20 publications

(18 citation statements)

References 34 publications

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“…Furthermore, the association of CDKN2A (MIM:600160) with pancreatic cancer had been curated in OMIM [11]. The rank of UCA1 was seven, and Kaneko et al [39] showed that UCA1 and BMF were upregulated in gallbladder epithelia of children with pancreaticobiliary malfunction. Therefore, our results suggested that UCA1 might be associated with pancreatic disease.…”

Section: Resultsmentioning

confidence: 99%

A Network Based Method for Analysis of lncRNA-Disease Associations and Prediction of lncRNAs Implicated in Diseases

et al. 2014

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Increasing evidence has indicated that long non-coding RNAs (lncRNAs) are implicated in and associated with many complex human diseases. Despite of the accumulation of lncRNA-disease associations, only a few studies had studied the roles of these associations in pathogenesis. In this paper, we investigated lncRNA-disease associations from a network view to understand the contribution of these lncRNAs to complex diseases. Specifically, we studied both the properties of the diseases in which the lncRNAs were implicated, and that of the lncRNAs associated with complex diseases. Regarding the fact that protein coding genes and lncRNAs are involved in human diseases, we constructed a coding-non-coding gene-disease bipartite network based on known associations between diseases and disease-causing genes. We then applied a propagation algorithm to uncover the hidden lncRNA-disease associations in this network. The algorithm was evaluated by leave-one-out cross validation on 103 diseases in which at least two genes were known to be involved, and achieved an AUC of 0.7881. Our algorithm successfully predicted 768 potential lncRNA-disease associations between 66 lncRNAs and 193 diseases. Furthermore, our results for Alzheimer's disease, pancreatic cancer, and gastric cancer were verified by other independent studies.

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Section: Resultsmentioning

confidence: 99%

A Network Based Method for Analysis of lncRNA-Disease Associations and Prediction of lncRNAs Implicated in Diseases

et al. 2014

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“…Both UCA1 and CUDR exhibit tissue specificity and were upregulated in human embryonic tissue and a limited set of normal tissues (Wang et al 2008;Tsang et al 2007), but also in cancer cell lines from different origin and cancerous patient tissue (Wang et al 2006(Wang et al , 2012bKaneko et al 2011;Fang et al 2014;Tian et al 2014;Han et al 2014;Tsang et al 2007).…”

Section: Uca1 Cudr/uca1amentioning

confidence: 99%

Long Noncoding RNAs in Lung Cancer

Roth

Diederichs

2015

Current Topics in Microbiology and Immunology

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Despite great progress in research and treatment options, lung cancer remains the leading cause of cancer-related deaths worldwide. Oncogenic driver mutations in protein-encoding genes were defined and allow for personalized therapies based on genetic diagnoses. Nonetheless, diagnosis of lung cancer mostly occurs at late stages, and chronic treatment is followed by a fast onset of chemoresistance. Hence, there is an urgent need for reliable biomarkers and alternative treatment options. With the era of whole genome and transcriptome sequencing technologies, long noncoding RNAs emerged as a novel class of versatile, functional RNA molecules. Although for most of them the mechanism of action remains to be defined, accumulating evidence confirms their involvement in various aspects of lung tumorigenesis. They are functional on the epigenetic, transcriptional, and posttranscriptional level and are regulators of pathophysiological key pathways including cell growth, apoptosis, and metastasis. Long noncoding RNAs are gaining increasing attention as potential biomarkers and a novel class of druggable molecules. It has become clear that we are only beginning to understand the complexity of tumorigenic processes. The clinical integration of long noncoding RNAs in terms of prognostic and predictive biomarker signatures and additional cancer targets could provide a chance to increase the therapeutic benefit. Here, we review the current knowledge about the expression, regulation, biological function, and clinical relevance of long noncoding RNAs in lung cancer.

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“…One example of such an oncogenic lncRNA is urothelial carcinoma-associated 1 (UCA1), which is believed to function in regulation of embryonic development and in bladder cancer invasion and progression [18,19]. It regulates the expression of several genes involved in tumorigenesis and/or embryonic development [20].…”

Section: Introductionmentioning

confidence: 99%

Potential roles of abnormally expressed long noncoding RNA UCA1 and Malat-1 in metastasis of melanoma

et al. 2014

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Melanoma is a highly aggressive skin cancer with increasing incidence worldwide. Long noncoding RNAs (lncRNAs), a group of nonprotein-coding transcripts longer than 200 nucleotides, are pervasively transcribed in the genome and are emerging as new players in tumorigenesis. The primary objective of this study was to investigate the role of six cancer-related lncRNAs in pairs of melanoma and adjacent normal tissues (ANTs). A total of 63 primary melanoma, paired ANTs, and metastatic lesions were collected in a Chinese population. Real-time PCR analysis was carried out to compare a series of cancer-related lncRNAs among primary melanoma tissues, ANTs, and metastatic lesions. In in-vitro studies, transwell migration assay was carried out to estimate the migration abilities of melanoma cells with different expression levels of urothelial carcinoma-associated 1 (UCA1) or metastasis-associated lung adenocarcinoma transcript 1 (Malat-1) lncRNAs. We found that UCA1 and Malat-1 lncRNAs were markedly more increased in melanomas than in paired ANTs (P<0.05). Melanomas at later stages (stages 3-4) showed higher expression of UCA1 lncRNA than those at early stages (stages 1-2) (P=0.455). In melanomas with lymph node metastasis, the metastatic lesions had a relatively higher expression of Malat-1 lncRNA than in paired primary tumors (P=0.414). Knockdown of UCA1 or Malat-1 lncRNA could attenuate the migrational ability of melanoma cells in in-vitro studies. Increased expression of UCA1 and Malat-1 lncRNAs might have a correlation with melanoma metastasis.

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Gene Expression Profiling Reveals Upregulated UCA1 and BMF in Gallbladder Epithelia of Children With Pancreaticobiliary Maljunction

Cited by 20 publications

References 34 publications

A Network Based Method for Analysis of lncRNA-Disease Associations and Prediction of lncRNAs Implicated in Diseases

A Network Based Method for Analysis of lncRNA-Disease Associations and Prediction of lncRNAs Implicated in Diseases

Long Noncoding RNAs in Lung Cancer

Potential roles of abnormally expressed long noncoding RNA UCA1 and Malat-1 in metastasis of melanoma

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