Gene expression signature for recurrence in stage III colorectal cancers

Watanabe, Toshiaki; Kobunai, Takashi; Sakamoto, Etsuko; Yamamoto, Yasutake; Konishi, Tsuyoshi; Horiuchi, Atsushi; Shimada, Ryu; Oka, Toshinori; Nagawa, Hirokazu

doi:10.1002/cncr.24023

Cited by 27 publications

(14 citation statements)

References 18 publications

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“…In oncology, gene expression profiling has been used to identify transcriptional signatures that predict several aspects of disease behavior, including risk of metastasis and response to chemotherapy (26)(27)(28). Where such techniques have previously been applied to autoimmune and inflammatory conditions, they have generally not detected signatures with equivalent prognostic utility.…”

Section: Discussionmentioning

confidence: 99%

Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis

Lee¹,

Lyons²,

McKinney³

et al. 2011

J. Clin. Invest.

283

258

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Crohn disease (CD) and ulcerative colitis (UC) are increasingly common, chronic forms of inflammatory bowel disease. The behavior of these diseases varies unpredictably among patients. Identification of reliable prognostic biomarkers would enable treatment to be personalized so that patients destined to experience aggressive disease could receive appropriately potent therapies from diagnosis, while those who will experience more indolent disease are not exposed to the risks and side effects of unnecessary immunosuppression. Using transcriptional profiling of circulating T cells isolated from patients with CD and UC, we identified analogous CD8 + T cell transcriptional signatures that divided patients into 2 otherwise indistinguishable subgroups. In both UC and CD, patients in these subgroups subsequently experienced very different disease courses. A substantially higher incidence of frequently relapsing disease was experienced by those patients in the subgroup defined by elevated expression of genes involved in antigen-dependent T cell responses, including signaling initiated by both IL-7 and TCR ligation -pathways previously associated with prognosis in unrelated autoimmune diseases. No equivalent correlation was observed with CD4 + T cell gene expression. This suggests that the course of otherwise distinct autoimmune and inflammatory conditions may be influenced by common pathways and identifies what we believe to be the first biomarker that can predict prognosis in both UC and CD from diagnosis, a major step toward personalized therapy.

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Section: Discussionmentioning

confidence: 99%

Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis

Lee¹,

Lyons²,

McKinney³

et al. 2011

J. Clin. Invest.

283

258

View full text Add to dashboard Cite

show abstract

“…Reproductive System Disease 0 1 2 3 4 5 6 7 8 9 -log(p-value) 10 given that only 50% of the stage III tumors in the study had that expression pattern. That is not surprising given the heterogeneity and complexity of rectal cancer biology.…”

Section: Cancermentioning

confidence: 95%

“…Gene signatures have been used in colorectal cancer to define biological pathways, describe differences in treatment response, and predict outcomes. [7][8][9][10] Gene expression studies have also been used to develop signatures that predict lymph node involvement in colorectal cancer. 11,12 These studies are hindered by small sample sizes and the combined analysis of both colon and rectal cancers.…”

mentioning

confidence: 99%

High-Throughput Arrays Identify Distinct Genetic Profiles Associated With Lymph Node Involvement in Rectal Cancer

Kalady

Coffey

DeJulius

et al. 2012

Diseases of the Colon &Amp; Rectum

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“…This approach already has begun to have a significant impact on the classification and prognosis of multiple types of cancer. Expression profiling already has been used in colon cancer specimens, with promising results, and defined cassettes of genes have been proposed in several studies to have the resolution to discriminate among tumors of different stages and prognoses (Table 1) [13][14][15][16][17][18][19][20]. qPCR qPCR is a revolutionary molecular biology technique that allows amplification and quantification in real time of mRNA from specific specimens in fresh frozen or fixed, paraffin-embedded tissues.…”

Section: Microarray Expression Profilingmentioning

confidence: 99%

Using The Colon Cancer Multigene Recurrence Score to Determine Risk: Prognostic Milestone or a Step in the Right Direction?

Wilson

Bohanes

Lenz

2010

Curr Colorectal Cancer Rep

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Although early-stage colon cancer is potentially curable by surgery, a significant number of patients will experience recurrence and eventually progress to metastatic disease. Although the implementation of adjuvant chemotherapy in stage III disease is recommended, its role in stage II disease remains controversial in clinical practice. The accumulating clinical data strongly indicate that a subset of patients with stage II disease are at increased risk for recurrence and often are not identified by standard clinical and histopathologic features. Recently, research efforts have attempted to identify specific cassettes of markers or gene signatures with the specificity and sensitivity to identify patients at increased risk for recurrence. In an era of personalized medicine, using such biomarkers will assist in identifying high-risk patients and allow the appropriation of adjuvant chemotherapy to reduce the risk of recurrence. In this review, we discuss the development and validation of genetic signatures to predict tumor recurrence and their current status, including the technologies involved and recent experiences in breast cancer. Finally, we describe the proposed recurrence score multigene signature for identifying high-risk stage II colon cancer.

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Gene expression signature for recurrence in stage III colorectal cancers

Abstract: BACKGROUND: Colorectal cancer patients with lymph node metastases (stage III) show poorer prognosis

Cited by 27 publications

References 18 publications

Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis

Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis

High-Throughput Arrays Identify Distinct Genetic Profiles Associated With Lymph Node Involvement in Rectal Cancer

Using The Colon Cancer Multigene Recurrence Score to Determine Risk: Prognostic Milestone or a Step in the Right Direction?

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