Gene expressions and copy numbers associated with metastatic phenotypes of uterine cervical cancer

Lyng, Heidi; Brøvig, Runar S; Svendsrud, Debbie Hege; Holm, Ruth; Kaalhus, Olav; Knutstad, K.; Oksefjell, H.; Sundfør, Kolbein; Kristensen, Gunnar B.; Stokke, Trond

doi:10.1186/1471-2164-7-268

Cited by 130 publications

(99 citation statements)

References 52 publications

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“…Further, DNAJC9 was shown to physically interact with Replication protein A (RPA2), which is involved in DNA replication and repair [38] (Additional file 1: Figure S11B). These genes were also shown to be dysregulated in cancer: C9orf40 was reported to be dysregulated in ovarian carcinoma [39] whereas DNAJC9 was shown to be up-regulated in metastatic cervical cancer in cancer stem cells [40, 41]. …”

Section: Discussionmentioning

confidence: 99%

Meta-analysis reveals conserved cell cycle transcriptional network across multiple human cell types

2017

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BackgroundCell division is central to the physiology and pathology of all eukaryotic organisms. The molecular machinery underpinning the cell cycle has been studied extensively in a number of species and core aspects of it have been found to be highly conserved. Similarly, the transcriptional changes associated with this pathway have been studied in different organisms and different cell types. In each case hundreds of genes have been reported to be regulated, however there seems to be little consensus in the genes identified across different studies. In a recent comparison of transcriptomic studies of the cell cycle in different human cell types, only 96 cell cycle genes were reported to be the same across all studies examined.ResultsHere we perform a systematic re-examination of published human cell cycle expression data by using a network-based approach to identify groups of genes with a similar expression profile and therefore function. Two clusters in particular, containing 298 transcripts, showed patterns of expression consistent with cell cycle occurrence across the four human cell types assessed.ConclusionsOur analysis shows that there is a far greater conservation of cell cycle-associated gene expression across human cell types than reported previously, which can be separated into two distinct transcriptional networks associated with the G1/S-S and G2-M phases of the cell cycle. This work also highlights the benefits of performing a re-analysis on combined datasets.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-016-3435-2) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Meta-analysis reveals conserved cell cycle transcriptional network across multiple human cell types

2017

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“…In addition, expression of MRPL11 was different between the node positive and negative tumors. The prognostic genes were clustered into two groups based on their metastatic phenotypes, and MRPL11 and MRPS23 were grouped based their association with rapid proliferation, oxidative phosphorylation, invasiveness, and tumor size [112]. In yeast, the cytoplasmic ribosomal homolog RP11 binds and suppresses the E3 ubiquitin-protein ligase function of HDM2 and leads to the stabilization and activation of the p53 tumor suppressor protein [113, 114] under conditions of growth inhibition, DNA damage and oncogenic insults [115].…”

Section: Mitoribosome Components As Biomarkers and Their Associatimentioning

confidence: 99%

Mitochondrial ribosomes in cancer

Kim

Maiti

Barrientos

2017

Seminars in Cancer Biology

150

120

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Mitochondria play fundamental roles in the regulation of life and death of eukaryotic cells. They mediate aerobic energy conversion through the oxidative phosphorylation (OXPHOS) system, and harbor and control the intrinsic pathway of apoptosis. As a descendant of a bacterial endosymbiont, mitochondria retain a vestige of their original genome (mtDNA), and its corresponding full gene expression machinery. Proteins encoded in the mtDNA, all components of the multimeric OXPHOS enzymes, are synthesized in specialized mitochondrial ribosomes (mitoribosomes). Mitoribosomes are therefore essential in the regulation of cellular respiration. Additionally, an increasing body of literature has been reporting an alternative role for several mitochondrial ribosomal proteins as apoptosis-inducing factors. No surprisingly, the expression of genes encoding for mitoribosomal proteins, mitoribosome assembly factors and mitochondrial translation factors is modified in numerous cancers, a trait that has been linked to tumorigenesis and metastasis. In this article, we will review the current knowledge regarding the dual function of mitoribosome components in protein synthesis and apoptosis and their association with cancer susceptibility and development. We will also highlight recent developments in targeting mitochondrial ribosomes for the treatment of cancer.

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“…Major mutations in MRPs can lead to functional changes in mitochondrial translation and can be lethal (Miller et al, 2004; Jacobs and Turnbull, 2005; Saada et al, 2007; Galmiche et al, 2011; Rotig, 2011; Smits et al, 2011). Aberrantly expressed MRPs are also observed in many different tumors, including in breast cancer, gliomas, squamous cell carcinoma, and osteosarcoma (Bonnefoy et al, 2001; Koc et al, 2001b; Mariani et al, 2001; Miller et al, 2004; Lyng et al, 2006). Therefore, a complete list of mitochondrial ribosomal proteins will be fundamental to our understanding of the mitochondrial translational machinery and its contribution to mitochondrial ATP production in health and disease.…”

Section: Introductionmentioning

confidence: 99%

Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome

et al. 2013

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Defects in mitochondrial ribosomal proteins (MRPs) cause various diseases in humans. Because of the essential role of MRPs in synthesizing the essential subunits of oxidative phosphorylation (OXPHOS) complexes, identifying all of the protein components involved in the mitochondrial translational machinery is critical. Initially, we identified 79 MRPs; however, identifying MRPs with no clear homologs in bacteria and yeast mitochondria was challenging, due to limited availability of expressed sequence tags (ESTs) in the databases available at that time. With the improvement in genome sequencing and increased sensitivity of mass spectrometry (MS)-based technologies, we have established four previously known proteins as MRPs and have confirmed the identification of ICT1 (MRP58) as a ribosomal protein. The newly identified MRPs are MRPS37 (Coiled-coil-helix-coiled-coil-helix domain containing protein 1-CHCHD1), MRPS38 (Aurora kinase A interacting protein1, AURKAIP1), MRPS39 (Pentatricopeptide repeat-containing protein 3, PTCD3), in the small subunit and MRPL59 (CR-6 interacting factor 1, CRIF1) in the large subunit. Furthermore, we have demonstrated the essential roles of CHCHD1, AURKAIP1, and CRIF1in mitochondrial protein synthesis by siRNA knock-down studies, which had significant effects on the expression of mitochondrially encoded proteins.

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Gene expressions and copy numbers associated with metastatic phenotypes of uterine cervical cancer

Cited by 130 publications

References 52 publications

Meta-analysis reveals conserved cell cycle transcriptional network across multiple human cell types

Meta-analysis reveals conserved cell cycle transcriptional network across multiple human cell types

Mitochondrial ribosomes in cancer

Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome

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