Gene–gene and gene–environment interactions defining lipid-related traits

Ordovás, José M.; Robertson, Ruairi C.; Cléirigh, Ellen Ní

doi:10.1097/mol.0b013e32834477a9

Cited by 46 publications

(33 citation statements)

References 43 publications

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“…Han males had higher ApoA1 levels and lower TC levels than Jing males, whereas Han females had higher LDL-C levels than Jing females. It was widely realized that dyslipidemia as a serious risk factor for CVD is a multifactorial and complicated disease caused by genetic factors, including lipid-associated gene variants and environmental factors, including age, sex, diet, alcohol consumption, cigarette smoking, obesity, exercise, hypertension [38, 39], and their interactions [12, 13]. …”

Section: Discussionmentioning

confidence: 99%

Association of the SPTLC3 rs364585 polymorphism and serum lipid profiles in two Chinese ethnic groups

et al. 2017

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BackgroundLittle is known about the association of the single nucleotide polymorphism (SNP) of rs364585 near serine palmitoyl-transferase long-chain base subunit 3 gene (SPTLC3) and serum lipid profiles. The present study was detected the association of the SPTLC3 rs364585 SNP and several environmental factors with serum lipid profiles in the Han and Jing populations.MethodsGenotyping of the SPTLC3 rs364585 SNP was performed in 824 unrelated individuals of Han and 783 participants of Jing by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis, and then confirmed by direct sequencing.ResultsThere was no significant difference in either genotypic or allelic frequencies between Han and Jing, or between males and females of the both ethnic groups. The levels of serum low-density lipoprotein cholesterol (LDL-C) and the ratio of apolipoprotein (Apo) A1 to ApoB in Han; and total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and LDL-C in Jing were different between the A allele carriers and the A allele non-carriers (P < 0.05-0.001). Subgroup analysis according to sex showed that the levels of LDL-C in Han males; TC and LDL-C in Jing males; and HDL-C and LDL-C in Jing females were different between the A allele carriers and the A allele non-carriers (P < 0.05-0.001), the A allele carriers had higher LDL-C and TC levels, and lower HDL-C levels than the A allele non-carriers. Serum lipid traits were also associated with several environmental factors in the Han and Jing populations, or in males and females of the both ethnic groups.ConclusionsThe present study demonstrates the association between the SPTLC3 rs364585 SNP and serum TC, HDL-C and LDL-C levels in our study populations. These associations might have ethnic- and/or sex-specificity.Trial registrationRetrospectively registered.

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Section: Discussionmentioning

confidence: 99%

Association of the SPTLC3 rs364585 polymorphism and serum lipid profiles in two Chinese ethnic groups

et al. 2017

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“…These humbling statistics confirm the complex nature of obesity and the need to identify additional factors including interactions between multiple genes and environmental factors [10][11][12]. Moreover, epigenetic modifications may be responsible for a significant proportion of the apparent missing heritability as well as the mechanisms by which the environment could induce metabolic changes with lasting effects.…”

mentioning

confidence: 78%

Epigenetics Lights Up the Obesity Field

Marti

Ordovas²

2011

Obes Facts

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“…Epigenetic alterations have become more and more significantly associated with gene-diet and gene-environment interactions resulting in altered lipid metabolism, inflammation, and other metabolic imbalances leading to CV disease and obesity [43]. The accumulation of homocysteine in blood leads to an intracellular increase in S-adenosylhomocysteine (AdoHcy), which is a potent, competitive methyltransferase inhibitor [44].…”

Section: Inflammation Specific Nutritional Factors Epigenetics Andmentioning

confidence: 99%

Epigenetics in the development, modification, and prevention of cardiovascular disease

Whayne

2014

Mol Biol Rep

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Epigenetics has major relevance to all disease processes; cardiovascular (CV) disease and its related conditions are no exception. Epigenetics is defined as the study of heritable alterations in gene expression, or cellular phenotype, and goes far beyond a pure genetic approach. A more precise definition is that epigenetics represents all the meiotically and mitotically inherited changes in gene expression that are not encoded on the deoxyribonucleic acid (DNA) sequence itself. Major epigenetic mechanisms are modifications of histone proteins in chromatin and DNA methylation (which does not alter the DNA sequence). There is increasing evidence for the involvement of epigenetics in human disease such as cancer, inflammatory disease and CV disease. Other chronic diseases are also susceptible to epigenetic modification such as metabolic diseases including obesity, metabolic syndrome, and diabetes mellitus. There is much evidence for the modification of epigenetics by nutrition and exercise. Through these modifications, there is infinite potential for benefit for the fetus, the newborn, and the individual as well as population effects. Association with CV disease, including coronary heart disease and peripheral vascular disease, is evident through epigenetic relationships and modification by major CV risk factors such as tobacco abuse. Aging itself may be altered by epigenetic modification. Knowledge of epigenetics and its relevance to the development, modification, and prevention of CV disease is in a very preliminary stage but has an infinite future.

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Gene–gene and gene–environment interactions defining lipid-related traits

Cited by 46 publications

References 43 publications

Association of the SPTLC3 rs364585 polymorphism and serum lipid profiles in two Chinese ethnic groups

Association of the SPTLC3 rs364585 polymorphism and serum lipid profiles in two Chinese ethnic groups

Epigenetics Lights Up the Obesity Field

Epigenetics in the development, modification, and prevention of cardiovascular disease

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