Gene–gene interaction analysis of personality traits in a Japanese population using an electrochemical DNA array chip analysis

Urata, Tomohiro; Takahashi, Nagahide; Hakamata, Yuko; Iijima, Yoshimi; Kuwahara, Natsumi; Ozaki, Norio; Ono, Yutaka; Amano, Masahiko; Inada, Toshiya

doi:10.1016/j.neulet.2006.12.018

Cited by 29 publications

(19 citation statements)

References 10 publications

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“…Jacob et al 55 also found no association between the MAOA-mVNTR and neuroticism or personality dimensions, except that the hemi-and homozygous genotypes for the 3-repeat variant was more frequent among cluster B personality disorder patients. Another study did not find association between this polymorphism alone and neuroticism, but reported a marginally significant gene--gene interaction between the MAOA-mVNTR, COMT (Val158Met), dopamine receptor type 3 gene (DRD3) (Ser9Gly) polymorphisms and agreeableness in Japanese females 56 . Additionally, no association was found between shyness in grade school students and the MAOA promoter region polymorphism 57 .…”

Section: Neuroticism and Personality Traits/disordersmentioning

confidence: 94%

O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos

Nishioka¹,

Perin²,

Sampaio³

et al. 2011

Rev. psiquiatr. clín.

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Introduction: A functional variable number of tandem repeats (VNTR) polymorphism of the promoter region of the monoamine oxidase A (MAOA) gene has been described and many studies have investigated the association of this polymorphism with human behaviors, as well as with several psychiatric disorders. Objective: This study aimed to review the literature on the role of the VNTR functional polymorphism of the promoter region of the MAOA gene on the modulation of human behavior for the development of psychiatric disorders. Method: Searches on the Medline, Embase, Web of Science and PsycInfo databases were performed including works from January 1998 to June 2009. The words used were: "MAOA and human behavior" and "MAOA and psychiatry". Results: Several studies were found (N = 3,873). After the selection process, 109 papers were included in the review. There was found an association of MAOA low activity alleles with antisocial personality disorder, conduct disorder, ADHD, pathological gambling, and substance abuse. High activity alleles were associated with neuroticism, anorexia nervosa and depression and anxiety disorders. There was no association between the MAOA polymorphisms and bipolar disorder and schizophrenia. Discussion: The main findings, summarized in this paper, support a role of MAOA VNTR polymorphism in some psychiatric disorders although some divergences were found due to methodological difficulties in genetic studies. In general, the studies associated the low activity alleles with impulsivity and aggressive behavior ("hyperactive behaviors"), and the high activity alleles of the gene with "hypoactive behaviors", such as depression and anxiety, which demonstrates a modulation of the MAOA enzyme in "hyperactive" and "hypoactive" disorders.

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Section: Neuroticism and Personality Traits/disordersmentioning

confidence: 94%

O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos

Nishioka¹,

Perin²,

Sampaio³

et al. 2011

Rev. psiquiatr. clín.

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“…Traits such as harm avoidance (HA) in TCI, neuroticism in NEO, and BIS all belong to negative emotionality (NEM), whereas novelty seeking (NS) in TCI, extraversion in NEO, and BAS belong to positive emotionality (PEM; Reuter et al, 2006b). Associations between COMT Val/Met and PEM/NEM were quite mixed, with nine studies showing no significant associations (Strobel et al, 2003;Tochigi et al, 2006;Ishii et al, 2007;Light et al, 2007;Urata et al, 2007;Sheldrick et al, 2008;Calati et al, 2011;Kang et al, 2010;Salo et al, 2010), seven studies showing the Val allele associated with high PEM or low NEM (Enoch et al, 2003;Tsai et al, 2004;Reuter and Hennig, 2005;Stein et al, 2005;Hoth et al, 2006;Hashimoto et al, 2007;Wacker and Gatt, 2010), and three studies showing the opposite (Met allele associated with high PEM or low NEM; Kim et al, 2006;Golimbet et al, 2007;Demetrovics et al, 2010), and three studies reported opposite pattern for males and females (Eley et al, 2003;Reuter et al, 2006b;Lang et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Sex Modulates the Associations Between the COMT Gene and Personality Traits

Chen

Moyzis

Dong

et al. 2011

Neuropsychopharmacol

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Previous research has shown inconsistent findings regarding the relations between the functional Val158Met polymorphisms of the catechol-O-methyltransferase (COMT) gene and individual differences in personality traits. This study attempts to overcome some of the weaknesses of previous research, namely, small sample sizes, clinical samples, ethnic stratification, wide age ranges, neglecting sex differences, and single measures of personality traits. A large sample (n ¼ 556, 250 male, 306 female) of healthy Chinese college students (mean age ¼ 20.5 ± 1 years) was given a battery of personality scales, including the temperament and character inventory-revised, the behavioral inhibition system and behavioral approach system scale, the Beck depression inventory, and the Beck anxiety inventory. Factor analysis of the affect-related personality traits revealed two factors that corresponded to positive (PEM) and negative emotionality (NEM). We found a consistent COMT-by-sex interaction effect on affect-related personality traits. Compared with males with Met/Met alleles, males with Val/Val alleles showed significantly higher scores on NEM, but lower scores on PEM. Females, however, showed an opposite but nonsignificant pattern. Our results supported the role of the COMT gene in personality traits for males and contributed to the growing literature on sex differences in gene-behavior connections.

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“…Other genes implicated in personality development include the MAOA enzyme (Soliman et al, 2011;Urata et al, 2007), GABRA6 (Alfimova et al, 2010), BDNF (Suzuki et al, 2011;Terracciano et al, 2010a), and COMT Urata et al, 2007). Unfortunately, negative reports are ubiquitous (Jorm et al, 2000;Lee et al, 2008).…”

Section: Other Genes Of Interestmentioning

confidence: 99%

Trends and Directions in Personality Genetic Studies

Kim¹,

Kim²

2011

Genomics & Informatics

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How personality forms and whether personality genes exist are long-studied questions. Various concepts and theories have been presented for centuries. Personality is a complex trait and is developed through the interaction of genes and the environment. Twin and family studies have found that there are critical genetic and environmental components in the inheritance of personality traits, and modern advances in genetics are making it possible to identify specific variants for personality traits. Although genes that were found in studies on personality have not provided replicable association between genetic and personality variability, more and more genetic variants associated with personality traits are being discovered. Here, we present the current state of the art on genetic research in the personality field and finally list several of the recently published research highlights. First, we briefly describe the commonly used self-reported measures that define personality traits. Then, we summarize the characteristics of the candidate genes for personality traits and investigate gene variants that have been suggested to be associated with personality traits.

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Gene–gene interaction analysis of personality traits in a Japanese population using an electrochemical DNA array chip analysis

Cited by 29 publications

References 10 publications

O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos

O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos

Sex Modulates the Associations Between the COMT Gene and Personality Traits

Trends and Directions in Personality Genetic Studies

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