2020
DOI: 10.21203/rs.2.21098/v1
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Gene networks and expression quantitative trait loci associated with platinum-based chemotherapy response in high-grade serous ovarian cancer

Abstract: Background A major impediment in the treatment of ovarian cancer is the relapse of platinum-resistant tumors, which occurs in approximately 25% of patients. A better understanding of the biological mechanisms underlying platinum-based response will improve treatment efficacy through genetic testing and novel therapies.Methods Using data from high-grade serous ovarian carcinoma (HGSOC) patients in the Cancer Genome Atlas (TCGA), we classified those who remained progression-free for 12 months following platinum-… Show more

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“…Initial version of this manuscript have been deposited in a non-commercial preprint repository (bioRxiv accession number: 740696). 60…”
Section: Availability Of Data and Materialsmentioning
confidence: 99%
“…Initial version of this manuscript have been deposited in a non-commercial preprint repository (bioRxiv accession number: 740696). 60…”
Section: Availability Of Data and Materialsmentioning
confidence: 99%