2023
DOI: 10.1016/j.tranon.2023.101795
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Gene partners of the EWSR1 fusion may represent molecularly distinct entities

Victoria Walker,
Dexter X. Jin,
Sherri Z. Millis
et al.
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Cited by 3 publications
(4 citation statements)
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“…Recently, a number of rare EWSR1 partners were reported in a genomic study of tumor cases profiled with NGS panels, with most of them being sarcomas but with carcinomas also present [23]. Here, we describe three new examples of rare GFs in sarcoma, further expanding the growing catalogue of EWSR1 partner genes that may define specific entities with distinct prognostic and therapeutic implications.…”
Section: Introductionmentioning
confidence: 79%
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“…Recently, a number of rare EWSR1 partners were reported in a genomic study of tumor cases profiled with NGS panels, with most of them being sarcomas but with carcinomas also present [23]. Here, we describe three new examples of rare GFs in sarcoma, further expanding the growing catalogue of EWSR1 partner genes that may define specific entities with distinct prognostic and therapeutic implications.…”
Section: Introductionmentioning
confidence: 79%
“…The three cases we have presented expressed GF transcripts involving EWSR1 as a 5 ′ partner and novel or rare 3 ′ partners, two of which had not been reported before. There seems to be an ever-expanding catalogue of genes that translocate with EWSR1, and interestingly, EWSR1 GFs with uncommon partners are associated with a higher frequency of mutations in actionable genes [13,14,23]. Different EWSR1 fusion partners endow the tumoral cells with specific properties, which, together with the cellular context and additional genetic alterations, determine the distinct biological features of each entity.…”
Section: Discussionmentioning
confidence: 99%
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