Gene polymorphism of C106T “rs759853” is not associated with diabetic retinopathy in Egyptian patients with type 2 diabetes mellitus

Shawki, Hadeel Ahmed; Elzehery, Rasha; Abo-Hashem, Ekbal M.; Shahin, Maha; Youssef, Magdy M.

doi:10.1016/j.genrep.2020.100865

Cited by 2 publications

(2 citation statements)

References 24 publications

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“…Some AR inhibitors as drug candidates have been developed for treatment of diabetic complications [74]. In a study on an Egyptian population the role of C106T rs759853 polymorphism was excluded in conferring the risk of DR. As indicated by the authors of this study, this polymorphism was not an independent genetic risk factor for DR [75].…”

Section: Chromosomesupporting

confidence: 48%

The Role of Genetic Polymorphisms in Diabetic Retinopathy: Narrative Review

Sienkiewicz-Szłapka,

Fiedorowicz,

Król-Grzymała

et al. 2023

IJMS

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Diabetic retinopathy (DR) is renowned as a leading cause of visual loss in working-age populations with its etiopathology influenced by the disturbance of biochemical metabolic pathways and genetic factors, including gene polymorphism. Metabolic pathways considered to have an impact on the development of the disease, as well as genes and polymorphisms that can affect the gene expression, modify the quantity and quality of the encoded product (protein), and significantly alter the metabolic pathway and its control, and thus cause changes in the functioning of metabolic pathways. In this article, the screening of chromosomes and the most important genes involved in the etiology of diabetic retinopathy is presented. The common databases with manuscripts published from January 2000 to June 2023 have been taken into consideration and chosen. This article indicates the role of specific genes in the development of diabetic retinopathy, as well as polymorphic changes within the indicated genes that may have an impact on exacerbating the symptoms of the disease. The collected data will allow for a broader look at the disease and help to select candidate genes that can become markers of the disease.

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Section: Chromosomesupporting

confidence: 48%

The Role of Genetic Polymorphisms in Diabetic Retinopathy: Narrative Review

Sienkiewicz-Szłapka,

Fiedorowicz,

Król-Grzymała

et al. 2023

IJMS

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“…Interestingly, two recent studies of T2D in Eastern European and Arab populations demonstrated the opposite relationship, suggesting that the T allele is associated with increased risk and severity of DM, while the C allele is protective [61,62]. Finally, some studies have found no such association [63][64][65][66], including a 2018 meta-analysis [29]. It is possible that some of the variation in these findings is due to the racial heterogeneity of the studies in question; however, when stratifying by type of diabetes, the T allele of the SNP has been found to be protective against the development of DR in T1D regardless of the ethnic background [26,29]; therefore, differences in the pathogenesis of DR in T1D compared to T2D may also account for the heterogeneity of these findings.…”

Section: Genetic Studies 41 Candidate Gene Studiesmentioning

confidence: 99%

Genetics of Diabetic Retinopathy, a Leading Cause of Irreversible Blindness in the Industrialized World

Bhatwadekar

Shughoury

Belamkar

et al. 2021

Genes

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Diabetic retinopathy (DR) is a chronic complication of diabetes and a leading cause of blindness in the industrialized world. Traditional risk factors, such as glycemic control and duration of diabetes, are unable to explain why some individuals remain protected while others progress to a more severe form of the disease. Differences are also observed in DR heritability as well as the response to anti-vascular endothelial growth factor (VEGF) treatment. This review discusses various aspects of genetics in DR to shed light on DR pathogenesis and treatment. First, we discuss the global burden of DR followed by a discussion on disease pathogenesis as well as the role genetics plays in the prevalence and progression of DR. Subsequently, we provide a review of studies related to DR’s genetic contribution, such as candidate gene studies, linkage studies, and genome-wide association studies (GWAS) as well as other clinical and meta-analysis studies that have identified putative candidate genes. With the advent of newer cutting-edge technologies, identifying the genetic components in DR has played an important role in understanding DR incidence, progression, and response to treatment, thereby developing newer therapeutic targets and therapies.

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Gene polymorphism of C106T “rs759853” is not associated with diabetic retinopathy in Egyptian patients with type 2 diabetes mellitus

Cited by 2 publications

References 24 publications

The Role of Genetic Polymorphisms in Diabetic Retinopathy: Narrative Review

The Role of Genetic Polymorphisms in Diabetic Retinopathy: Narrative Review

Genetics of Diabetic Retinopathy, a Leading Cause of Irreversible Blindness in the Industrialized World

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