Gene Polymorphism of XRCC1 Arg399Gln and Cervical Carcinoma Susceptibility in Asians: A Meta-analysis Based on 1,759 Cases and 2,497 Controls

Liu, Yiting; Shi, Jingpu; Fu, Ling; Zhou, Bo; Wang, Hailong; Wu, Xiaohua

doi:10.7314/apjcp.2013.14.1.189

Cited by 8 publications

(3 citation statements)

References 19 publications

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“…More than 300 validated single nucleotide polymorphisms in the XRCC1 gene were reported in the dbSNP database (http://www.ncbi.nlm.nih.gov/SNP), among them, rs25487 in XRCC1 codon 399 of exon 10 was the most extensively studied polymorphic site. Recently, meta-analysis studies have reported that XRCC1 Arg399Gln variant was associated with the risk of certain cancers, such as breast cancer [29], nasopharyngeal carcinoma [30], cervical carcinoma [31] and glioma [32]. In this paper, we performed a systematic literature review to comprehensively evaluate the association between sequence variants in XRCC1 Arg399Gln and the risk of squamous cell carcinoma of the head and neck.…”

Section: Discussionmentioning

confidence: 99%

Association of X-ray Repair Cross Complementing Group 1 Arg399Gln Polymorphisms with the Risk of Squamous Cell Carcinoma of the Head and Neck: Evidence from an Updated Meta-Analysis

et al. 2013

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BackgroundEpidemiologic studies have reported the association of X-ray repair cross-complementary group 1 (XRCC1) Arg399Gln polymorphisms with susceptibility to squamous cell carcinoma of the head and neck (HNSCC). However, the results were conflictive rather than conclusive. The purpose of this study was to clarify the association of XRCC1 Arg399Gln variants with HNSCC risk.MethodsSystematic searches were performed through the search engines of PubMed, Elsevier, Science Direct, CNKI and Chinese Biomedical Literature Database. Summary odds ratio (OR) with 95% confidence intervals (CI) was computed to estimate the strength association.ResultsOverall, we did not observe any association of XRCC1 Arg399Gln polymorphisms with HNSCC risk in total population (OR = 0.95, 95% CI: 0.76–1.19 for Gln/Gln vs. Arg/Arg, OR = 1.05, 95% CI: 0.92–1.20 for Arg/Gln vs. Arg/Arg, and OR = 1.03, 95% CI: 0.90–1.18 for Gln/Gln+Arg/Gln vs. Arg/Arg) based on 18 studies including 3917 cases and 4560 controls. In subgroup analyses, we observed an increased risk of XRCC1 399 Arg/Gln genotype for HNSCC in Caucasians (OR = 1.20, 95% CI: 1.00–1.44) and Gln/Gln genotype for larynx squamous cell carcinoma (OR = 1.63, 95% CI: 1.10–2.40). We did not observe any association between XRCC1 Arg399Gln variants and HNSCC risk in additional subgroup analyses.ConclusionThe results from this present meta-analysis suggest that XRCC1 Arg399Gln variants may contribute to HNSCC risk among Caucasians and to the risk of larynx squamous cell carcinoma. Further, well-designed studies with larger sample sizes are required to verify our findings.

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Section: Discussionmentioning

confidence: 99%

Association of X-ray Repair Cross Complementing Group 1 Arg399Gln Polymorphisms with the Risk of Squamous Cell Carcinoma of the Head and Neck: Evidence from an Updated Meta-Analysis

et al. 2013

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“…6 XRCC1 memiliki tiga SNPs umum, varian genetik dalam XRCC1 adalah (C/T) dalam ekson 6 menghasilkan substitusi Arg / Trp pada kodon 194, (G/A) dalam ekson 9 mengubah asam amino Arg / His pada kodon 280 dan polimorfisme lain (G/A) dalam ekson 10 mengubah asam amino Arg / Gln pada kodon 399 pada stabilitas genomik. 6,7,8 Penelitian yang dilakukan pada populasi Asia menunjukkan hubungan yang signifikan antara polimorfisme XRCC1 Arg399Gln dan risiko karsinoma serviks. 9 Polimorfisme genetik adalah adanya variasi genetik pada suatu populasi dengan frekuensi lebih dari satu persen.…”

Section: Pendahuluanunclassified

Hubungan Polimorfisme Gen XRCC1 Arg399Gln Terhadap Kejadian Kanker Serviks Pada Wanita Ras Melayu

Sary¹,

Legiran²,

Saleh³

2018

BioJInd

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Kanker serviks merupakan kanker yang terjadi pada serviks atau leher rahim, suatu daerah yang terletak pada organ reproduksi wanita yang merupakan pintu masuk ke arah rahim, letaknya antara rahim (uterus) dan liang senggama atau vagina. Insiden terjadinya kanker serviks dipengaruhi oleh Human Papiloma Virus (HPV), usia, usia terlalu muda berhubungan seksual, paritas, riwayat keluarga dan RAS. Gen XRCC1 sebagai perancah dalam BER yang terlibat dalam membantu memperbaiki kesalahan-kesalahan selama replikasi DNA serta menjaga integritas genom. Single Nukleotida Polymorphism (SNP) di XRCC1 telah dikaitkan dengan pengembangan yang terjadi pada kanker serviks yang dapat mengurangi aktivitas perbaikan DNA, meningkatkan terjadinya mutasi sehingga kerentanan terhadap kanker. Penelitian ini bertujuan untuk melihat adakah hubungan polimorfisme gen XRCC1 Arg399Gln dengan kejadian kanker serviks. Penelitian ini merupakan penelitian observasional analitik dengan desain case-control dengan jumlah sampel sebanyak 35 orang wanita kanker serviks dan 35 orang wanita normal yang setiap sampel memiliki RAS melayu Jambi. Identifikasi polimorfisme gen XRCC1 Arg399Gln dilakukan dengan teknik PCR-RLFP amplifikasi dengan primer spesifik yang digunakan untuk melihat mutagenesis. Hasil analisis dengan uji Chi-Square genotipe G/G (Wild Type), G/A (Mutant Heterozigot) dan G/A (Mutant Heterozigot) terhadap kanker serviks nilai ? = 0,032 (OR : 10.074 ; CI : 1,186 -85,570). Kesimpulan ada hubungan polimorfisme genotip gen XRCC1 Arg399Gln terhadap kejadian kanker serviks pada wanita RAS Melayu Jambi.

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“…Recently, association studies between XRCC polymorphisms and different types of cancers including hematological malignancies have been performed [2,[7][8][9][10][11][12][13][14]. However, depending on cancer type and ethnic groups, the risk genotype of these polymorphisms are controversial [14].…”

Section: Introductionmentioning

confidence: 99%

Identification of XRCC1 Arg399Gln and XRCC3 Thr241Met Polymorphisms in a Turkish Population and Their Association with the Risk of Chronic Lymphocytic Leukemia

Mutlu

Elçi

Yıldırım

et al. 2014

Indian J Hematol Blood Transfus

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DNA repair systems are essential for cellular functions. Defects due to sequence variations in DNA repair genes can lead severe failure of cell functions and causing many cancer types including leukemia. The aim of this study was to investigate the relationship between XRCC1 Arg399Gln and XRCC3 Thr241Met polymorphisms and susceptibility to chronic lymphocytic leukemia (CLL) in Turkish patients. In addition, genotype distribution of these polymorphisms was compared with other populations. The frequencies of Arg399Gln and Thr241Met single nucleotide polymorphisms were studied in 25 CLL patients and 30 healthy individuals. Single nucleotide polymorphisms were genotyped by PCR-RFLP method. The genotype and allele frequencies of Arg399Gln and Thr241Met polymorphisms were not statistically different between the CLL patients and control group. The allelic frequency similarities were found between Turkish and Brazilian populations for Arg399Gln polymorphism. On the other hand, similarities were found between Turkish and other Caucasian populations for Thr241Met polymorphism. Marked differences were observed between American African versus Turkish and Chinese versus Turkish populations for Arg399Gln and Thr241Met polymorphisms respectively. These results indicate that Arg399Gln and Thr241Met polymorphisms were not associated with the development of CLL in Turkish population and ethnic differences is one of the most important factor for allele frequency differences.

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Gene Polymorphism of XRCC1 Arg399Gln and Cervical Carcinoma Susceptibility in Asians: A Meta-analysis Based on 1,759 Cases and 2,497 Controls

Cited by 8 publications

References 19 publications

Association of X-ray Repair Cross Complementing Group 1 Arg399Gln Polymorphisms with the Risk of Squamous Cell Carcinoma of the Head and Neck: Evidence from an Updated Meta-Analysis

Association of X-ray Repair Cross Complementing Group 1 Arg399Gln Polymorphisms with the Risk of Squamous Cell Carcinoma of the Head and Neck: Evidence from an Updated Meta-Analysis

Hubungan Polimorfisme Gen XRCC1 Arg399Gln Terhadap Kejadian Kanker Serviks Pada Wanita Ras Melayu

Identification of XRCC1 Arg399Gln and XRCC3 Thr241Met Polymorphisms in a Turkish Population and Their Association with the Risk of Chronic Lymphocytic Leukemia

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