Gene Polymorphisms and Febrile Neutropenia in Acute Leukemia—No Association with IL-4, CCR-5, IL-1RA, but the MBL-2, ACE, and TLR-4 Are Associated with the Disease in Turkish Patients: A Preliminary Study

Pehlıvan, Mustafa; Şahin, Handan Haydaroğlu; Özdilli, Kürşat; Önay, Hüseyin; Özcan, Ali; Özkınay, Ferda; Pehlıvan, Sacide

doi:10.1089/gtmb.2014.0004

Cited by 8 publications

(8 citation statements)

References 38 publications

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“…Our results consistent with results obtained by Pehlivan et al [30] which show that Gram-negative bacteremia was more common in deficient MBL2 AB/BB genotype. However our result inconsistent with study by Hellemann et al [31] in critically ill patients admitted to an intensive care, which reported an association of low MBL2 O/O genotype with an increased incidence of Gram-positive infections.…”

Section: Discussionsupporting

confidence: 93%

<i>MBL2</i> Gene Polymorphism and the Association with Neonatal Sepsis in Egyptian Neonates, a Case Control Study

Mashaly¹,

El-Sabbagh²,

El-Kazzaz³

et al. 2016

OJI

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Mannose binding lectin (MBL) is an important component of innate immunity particularly in neonates whose adaptive immunity is not fully developed. Polymorphism in MBL2 gene promoter and exon1 determines MBL serum level and function. The aim of this study was to investigate the frequency of different MBL2 genotypes in neonatal sepsis among patients of neonatal intensive care unit (NICU). Two hundred and forty-five neonates were enrolled in this study (127 infected and 118 uninfected controls). Multiplex PCR and double amplification refractory mutation system (dARMS) were used for typing of MBL2 exon1 and promoter respectively. Klebsiella species were the most frequently isolated organisms (22.8%). There is no statistical significance difference in the distribution of different expression genotypes between infected group and controls (P = 0.11). However, prevalence of low MBL2 expression genotypes (XA/O and O/O) was higher in infected patients compared to control group (patients 25.2% and controls 15.3%). Low and medium MBL2 expression genotypes were mostly associated with Gram-negative bacterial infections (18.9% and 22.8%) respectively. A statistically significant association of Gram-negative bacterial infections with low MBL2 expression genotypes was found (P = 0.02). Higher frequency of AB and BB genotypes was observed (31.5% and 7.9%) in patients group compared to control, but without statistical significant difference.

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Section: Discussionsupporting

confidence: 93%

<i>MBL2</i> Gene Polymorphism and the Association with Neonatal Sepsis in Egyptian Neonates, a Case Control Study

Mashaly¹,

El-Sabbagh²,

El-Kazzaz³

et al. 2016

OJI

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“…This could have affected the quality of their study if the episodes occurred within a short period of time (i.e. biomarker had not returned to baseline levels) or there was overrepresentation of patients with genetic predisposition to infections, in their biomarker response, or fever without adverse outcome …”

Section: Discussionmentioning

confidence: 99%

Updated systematic review and meta‐analysis of the predictive value of serum biomarkers in the assessment and management of fever during neutropenia in children with cancer

Arif

Phillips

2019

Pediatric Blood & Cancer

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Routinely measurable biomarkers as predictors for adverse outcomes in febrile neutropenia could improve management through risk stratification. This systematic review assesses the predictive role of biomarkers in identifying events such as bacteraemia, clinically documented infections, microbiologically documented infection, severe sepsis requiring intensive care or high dependency care and death. This review collates 8319 episodes from 4843 patients. C-reactive protein (CRP), interleukin (IL)-6, IL-8 and procalcitonin (PCT) consistently predict bacteraemia and severe sepsis; other outcomes have highly heterogeneous results. Performance of the biomarkers at admission using different thresholds demonstrates that PCT > 0.5 ng/mL offers the best compromise between sensitivity and specificity: sensitivity 0.67 (confidence interval [CI] 0.53-0.79) specificity 0.73 . Seventeen studies describe the use of serial biomarkers, with PCT having the greatest discriminatory role. Biomarkers, potentially with serial measurements, may predict adverse outcomes in paediatric febrile neutropenia and their role in risk stratification is promising.

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“…Several innate immune factors have been proposed as possible determinants of infectious morbidity in patients receiving chemotherapy. Among these are mannose-binding lectin (MBL2), ficolin, TLR-4 (135,145) and NOD2 (220). Much research has been done for MBL but the evidence for effects of MBL deficiency remains conflicting (7,46,55,62,101,105,116,139,142).…”

Section: Cim Diagnosis and Biomarkers Supported By Animal Modelsmentioning

confidence: 99%

Animal models of chemotherapy-induced mucositis: translational relevance and challenges

Sangild

Shen

Pontoppidan

et al. 2018

American Journal of Physiology-Gastrointestinal and Liver Physi

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Chemotherapy for cancer patients induces damaging tissue reactions along the epithelium of the gastrointestinal tract (GIT). This chemotherapy-induced mucositis (CIM) is a serious side effect of cytotoxic drugs, and several animal models of CIM have been developed, mainly in rodents and piglets, to help understand the progression of CIM and how to prevent it. Animal models allow highly controlled experimental conditions, detailed organ (e.g., GIT) insights, standardized, clinically relevant treatment regimens, and discovery of new biomarkers. Still, surprisingly few results from animal models have been translated into clinical CIM management and treatments. The results obtained from specific animal models can be difficult to translate to the diverse range of CIM manifestations in patients, which vary according to the antineoplastic drugs, dose, underlying (cancer) disease, and patient characteristics (e.g., age, genetics, and body constitution). Another factor that hinders the direct use of results from animals is inadequate collaboration between basic science and clinical science in relation to CIM. Here, we briefly describe CIM pathophysiology, particularly the basic knowledge that has been obtained from CIM animal models. These model studies have indicated potential new preventive and ameliorating interventions, including supplementation with natural bioactive diets (e.g., milk fractions, colostrum, and plant extracts), nutrients (e.g., polyunsaturated fatty acids, short-chain fatty acids, and glutamine), and growth factor peptides (e.g., transforming growth factor and glucagon-like peptide-2), as well as manipulations of the gut microbiota (e.g., prebiotics, probiotics, and antibiotics). Rodent CIM models allow well-controlled, in-depth studies of animals with or without tumors while pig models more easily make clinically relevant treatment regimens possible. In synergy, animal models of CIM provide the basic physiological understanding and the new ideas for treatment that are required to make competent decisions in clinical practice.

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Gene Polymorphisms and Febrile Neutropenia in Acute Leukemia—No Association with IL-4, CCR-5, IL-1RA, but the MBL-2, ACE, and TLR-4 Are Associated with the Disease in Turkish Patients: A Preliminary Study

Cited by 8 publications

References 38 publications

<i>MBL2</i> Gene Polymorphism and the Association with Neonatal Sepsis in Egyptian Neonates, a Case Control Study

<i>MBL2</i> Gene Polymorphism and the Association with Neonatal Sepsis in Egyptian Neonates, a Case Control Study

Updated systematic review and meta‐analysis of the predictive value of serum biomarkers in the assessment and management of fever during neutropenia in children with cancer

Animal models of chemotherapy-induced mucositis: translational relevance and challenges

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Gene Polymorphisms and Febrile Neutropenia in Acute Leukemia—No Association with IL-4, CCR-5, IL-1RA, but the MBL-2, ACE, and TLR-4 Are Associated with the Disease in Turkish Patients: A Preliminary Study

Cited by 8 publications

References 38 publications

&lt;i&gt;MBL2&lt;/i&gt; Gene Polymorphism and the Association with Neonatal Sepsis in Egyptian Neonates, a Case Control Study

&lt;i&gt;MBL2&lt;/i&gt; Gene Polymorphism and the Association with Neonatal Sepsis in Egyptian Neonates, a Case Control Study

Updated systematic review and meta‐analysis of the predictive value of serum biomarkers in the assessment and management of fever during neutropenia in children with cancer

Animal models of chemotherapy-induced mucositis: translational relevance and challenges

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Product

Resources

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<i>MBL2</i> Gene Polymorphism and the Association with Neonatal Sepsis in Egyptian Neonates, a Case Control Study

<i>MBL2</i> Gene Polymorphism and the Association with Neonatal Sepsis in Egyptian Neonates, a Case Control Study