Gene polymorphisms and serum levels of BDNF and CRH in vitiligo patients

Kussainova, Assiya; Kassym, Laura; Bekenova, Nazira; Akhmetova, Almira; Glushkova, Natalya; Kussainov, Almas; Urazalina, Zhanar; Yurkovskaya, Oksana; Smail, Yerbol; Pak, Laura; Semenova, Yuliya

doi:10.1371/journal.pone.0271719

Cited by 3 publications

(1 citation statement)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vitiligo patients exhibit a higher incidence of stressful life events prior to the onset of their condition 8 . The presence of depression-related polymorphisms in the BDNF and CRH genes and the elevated expression of in ammatory factors in the blood of individuals with pure depression provide evidence that anxiety and depression could not only result from the dis guring appearance of vitiligo, but could also play a signi cant role in the induction or exacerbation of the condition, thus affecting treatment outcomes 9,10 .…”

Section: Introductionmentioning

confidence: 99%

Analysis of the Causal Relationship Between Anxiety- Depression and Vitiligo and Its Impact on Disease Onset, Progression, and Therapeutic Efficacy

Cao,

Xu,

Zhou

et al. 2024

Preprint

View full text Add to dashboard Cite

Background Anxiety and depression are the most common psychiatric comorbidities among vitiligo patients. However, the impact on disease progression and outcomes remains unclear. Objective To elucidate the causal relationship between anxiety and depression and the progression and outcomes of vitiligo, providing a foundation for strengthening psychological interventions in the treatment of vitiligo. Methods Two-sample Mendelian randomization analysis was used to validate the causal relationship between depression and vitiligo. The Hospital Anxiety and Depression Scale (HADS) was used to assess the psychiatric condition of vitiligo patients. We conducted Fisher's chi-square tests and rank sum tests to analyse differences in clinical characteristics and outcomes among vitiligo patients with different HADS scores. Regression analysis was used to assess the correlation between anxiety-depression and disease progression, outcomes. Results Depression significantly increases the risk of the appearance of vitiligo (P = 0.03). Age, duration of the disease, body surface area, and VIDA were positive associated factors with HADS, with VIDA being the most influential. Univariate regression analysis demonstrated that HADS (P < 0.001) and VIDA (P < 0.001) were significant negative associated factors for disease outcomes. However, HADS (P < 0.001) emerged as the only factor that influenced the therapeutic efficacy in multivariate regression analysis. A restricted cubic spline graph illustrates a U-shaped relationship between HADS and clinical efficacy, with the most significant impact on therapeutic efficacy occurring when HADS is equal to 15. Conclusion Anxiety and depression exhibit a bidirectional positive causal relationship with vitiligo. Moderate to severe anxiety-depression constitutes a significant factor influencing the clinical efficacy of vitiligo treatment.

show abstract

Section: Introductionmentioning

confidence: 99%

Analysis of the Causal Relationship Between Anxiety- Depression and Vitiligo and Its Impact on Disease Onset, Progression, and Therapeutic Efficacy

Cao,

Xu,

Zhou

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Association between miR-202, miR-211, and miR-1238 gene polymorphisms and risk of vitiligo

Shahroudi,

Rezaei,

Mirzaeipour

et al. 2024

Arch Dermatol Res

View full text Add to dashboard Cite

Anxiety—depression: a pivotal mental factor for accelerating disease progression and reducing curative effect in vitiligo patients

Cao,

Lin,

Jin

et al. 2024

Front. Psychol.

View full text Add to dashboard Cite

ObjectiveTo clarify the causal relationship between anxiety-depression and the progression and outcomes of vitiligo, providing a basis for enhancing psychological interventions in the treatment of vitiligo.MethodsA two-sample Mendelian randomization analysis was used to validate the causal relationship between anxiety, depression, and vitiligo. The Hospital Anxiety and Depression Scale (HADS) assessed the psychiatric condition of vitiligo patients. Fisher’s chi-square tests and rank sum tests analyzed the differences in clinical characteristics among vitiligo patients with different HADS scores. Regression analysis assessed the correlation between anxiety-depression and disease progression and treatment outcomes.ResultsMendelian randomization analysis showed that depression significantly increases the risk of vitiligo (OR = 4.46, 95% CI: 1.16–17.18, p = 0.03). According to the HADS scores, clinical characteristics differed significantly among the groups (p < 0.05). Univariate regression analysis demonstrated that both HADS (B = –1.168, p < 0.001, 95% CI: −1.532 to −0.804) and VIDA (B = –2.157, p < 0.001, 95% CI: −3.464 to −0.887) were significantly negative associated factors for disease outcomes. However, HADS (B = –1.006, p < 0.001, 95% CI: −1.475 to −0.657) emerged as the only factor influencing therapeutic efficacy in multivariate regression analysis. A restricted cubic spline graph illustrates a U-shaped relationship between HADS and clinical efficacy, with the most significant impact on therapeutic efficacy occurring when HADS equals 15.ConclusionAnxiety—depression exhibit a bidirectional positive causal relationship with vitiligo. Moderate to severe anxiety-depression significantly influences the clinical efficacy of vitiligo treatment.

show abstract

Gene polymorphisms and serum levels of BDNF and CRH in vitiligo patients

Cited by 3 publications

References 52 publications

Analysis of the Causal Relationship Between Anxiety- Depression and Vitiligo and Its Impact on Disease Onset, Progression, and Therapeutic Efficacy

Analysis of the Causal Relationship Between Anxiety- Depression and Vitiligo and Its Impact on Disease Onset, Progression, and Therapeutic Efficacy

Association between miR-202, miR-211, and miR-1238 gene polymorphisms and risk of vitiligo

Anxiety—depression: a pivotal mental factor for accelerating disease progression and reducing curative effect in vitiligo patients

Contact Info

Product

Resources

About