Gene Polymorphisms of Toll-Like Receptor 9 −1486T/C and 2848G/A in Cervical Cancer Risk

Mu, Xiyan; Zhao, Jianming; Yuan, Xin; Zhao, Xiaowen; Yao, Kui; Liu, Yingwei; Zhao, Xia

doi:10.1097/igc.0000000000000494

Cited by 14 publications

(8 citation statements)

References 17 publications

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“…A previous meta-analysis on the relationship between TLR9 polymorphisms rs352140 and rs187084 and cervical cancer risk conducted by Mu et al is consistent with our results [ 37 ]. There were five studies of rs352140 and four case-control studies of rs187084 in the study of Mu et al that assessed the correlation between TLR9 SNPs and cervical cancer risk.…”

Section: Discussionsupporting

confidence: 93%

The Associations between Toll-Like Receptor 9 Gene Polymorphisms and Cervical Cancer Susceptibility

Tian

Zhang

Yang

et al. 2018

Mediators of Inflammation

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This meta-analysis systematically reviews the association between Toll-like receptor 9 polymorphisms and the risk of cervical cancer. Case-control studies focused on the association were collected from the PubMed, Web of Science, Cochrane Library, Embase, MEDLINE, CNKI, VIP, and Wanfang databases from inception to July 2017. We screened the studies and assessed the methodological quality of the included studies and extracted data. A meta-analysis was performed using RevMan 5.3 and Stata 12.0 software. Pooled odds ratios and 95% confidence intervals were employed to evaluate the strength of the associations between Toll-like receptor 9 polymorphisms and cervical cancer risk. A total of 9 studies comprising 3331 cervical cancer patients and 4109 healthy controls met the inclusion criteria. Of these, 8 studies contained information about G2848A (rs352140) and 4 studies contained information about −1486T/C (rs187084). Our results revealed that the associations between rs187084 and cervical cancer risk in the dominant model (p = 0.002) and heterozygous model (p = 0.002) were significant, with 1.30- and 1.32-fold increases in susceptibility, respectively, compared to that in the wild-type model. However, rs352140 was not related to cervical cancer regardless of whether the subgroup analysis was conducted (p > 0.05). In conclusion, there is a significant correlation between rs187084 and cervical cancer risk with the minor C allele increasing the risk of occurrence of cervical cancer. However, rs352140 is not associated with the occurrence of cervical cancer.

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Section: Discussionsupporting

confidence: 93%

The Associations between Toll-Like Receptor 9 Gene Polymorphisms and Cervical Cancer Susceptibility

Tian

Zhang

Yang

et al. 2018

Mediators of Inflammation

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“…These variants may exert various influences on the expression or function of a particular gene. 14 , 15 Even with the potential importance of HOTAIR in carcinogenesis, only a few studies have investigated the effects of HOTAIR SNPs on cancer susceptibility. For example, Guo et al reported that the mutated T allele of rs12826786 in HOTAIR could increase the risk of developing gastric cancer and was associated with TNM stage.…”

Section: Introductionmentioning

confidence: 99%

The association between HOTAIR polymorphisms and cancer susceptibility: an updated systemic review and meta-analysis

Liu

et al. 2018

OTT

Self Cite

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ObjectivesThis work aims to explore whether HOX transcript antisense intergenic RNA (HOTAIR) polymorphisms are associated with cancer susceptibility.Materials and methodsA comprehensive search was conducted for literature published from January 2007 to July 2017. The pooled odds ratios (ORs) and the corresponding 95% CIs were calculated using the Revman 5.2 software. Eighteen articles of 36 case–control studies were enrolled including six HOTAIR polymorphisms and 10 cancer types.ResultsThe results showed that cancer risk was elevated in recessive mutation of rs12826786 (TT vs CC+CT: OR =1.55, 95% CI =1.19, 2.03; TT+CT vs CC: OR =1.23, 95% CI =1.04, 1.46; TT vs CC: OR =1.67, 95% CI =1.24, 2.24; T vs C: OR =1.24, 95% CI =1.09, 1.40) and rs920778 (TT vs CC+CT: OR =1.73, 95% CI =1.30, 2.30; TT+CT vs CC: OR =1.40, 95% CI =1.16, 1.70; TT vs CC: OR =1.83, 95% CI =1.25, 2.68; T vs C: OR =1.37, 95% CI =1.18, 1.59), while the results for polymorphisms of rs7958904, rs4759314, rs874945, and rs1899663 were insignificant. The stratified results for Chinese population were consistent with the overall group analysis.ConclusionOur meta-analysis showed that HOTAIR polymorphisms of rs12826786 and rs920778 were correlated with increased cancer risk, while rs7958904, rs4759314, rs874945, and rs1899663 were not. More studies with different types of cancer are needed to confirm the findings.

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“…Another study analyzed the influence of three TLR9 polymorphisms on multiple cancers, and in the case of the TLR9-1237 TC (rs5743836) SNP, found a protective effect of the C variant allele on digestive system tumors and breast cancer. In contrast to the SNP TLR9-1486 CT (rs187084), there was a high risk for C wild allele carriers in cancer development, particularly in the case of cervical cancer in both the Chinese[13,24] and Caucasian populations[25]. Tian et al[13] stratified the population by race to eliminate heterogeneity, and demonstrated for the rs187084 SNP that the influence of heterogeneity decreased when stratified only among the Chinese population.…”

Section: Discussionmentioning

confidence: 99%

Toll-like receptor 9 polymorphisms and Helicobacter pylori influence gene expression and risk of gastric carcinogenesis in the Brazilian population.

Susi¹,

Lourenço²,

Rasmussen³

et al. 2019

WJGO

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BACKGROUNDToll-like receptors (TLRs) are the first line of host defense, and are involved in Helicobacter pylori (H. pylori) recognition and activation of both inflammatory and carcinogenic processes. The presence of single nucleotide polymorphisms (SNPs) in genes that activate the immune response may modulate the risk of precancerous lesions and gastric cancer (GC). Among them, Toll-like receptor 9 (TLR9) polymorphisms have emerged with a risk factor of infectious diseases and cancer, however the studies are still inconclusive.AIMTo evaluate whether TLR9 rs5743836 and rs187084 SNPs contribute to the risk of gastric carcinogenesis, and its influence on mRNA expression.METHODSA case-control study was conducted to evaluate two TLR9 SNPs (TLR9-1237 TC-rs5743836 and TLR9-1486 CT-rs187084) in chronic gastritis (CG) and GC patients. A total of 609 DNA samples of peripheral blood [248 CG, 161 GC, and 200 samples from healthy individuals (C)] were genotyped by polymerase chain reaction-restriction fragment length polymorphism. All samples were tested for the H. pylori infection using Hpx1 and Hpx2 primers. Quantitative polymerase chain reaction by TaqMan® assay was used to quantify TLR9 mRNA from fresh gastric tissues (48 GC, 26 CG, and 14 C).RESULTSFor TLR9-1237, the TC + CC or CC genotypes were associated with a higher risk of GC than C [recessive model odds ratio (OR) = 5.01, 95% confidence interval (CI): 2.52-9.94, P < 0.0001], and the CG (recessive model OR =4.63; 95%CI: 2.44-8.79, P < 0.0001) groups. For TLR9-1486, an association between the CT + TT genotypes and increased risk of both GC (dominant model OR = 2.72, 95%CI: 1.57-4.72, P < 0.0001) and CG (dominant model OR = 1.79, 95%CI: 1.15-2.79, P = 0.0094) was observed when compared to the C group. Moreover, the presence of TLR9-1237 TC/CC + TLR9-1486 CC genotypes potentiate the risk for this neoplasm (OR = 18.57; 95%CI: 5.06-68.15, P < 0.0001). The TLR9 mRNA level was significantly higher in the GC group (RQ = 9.24, P < 0.0001) in relation to the CG group (RQ = 1.55, P = 0.0010) and normal mucosa (RQ = 1.0). When the samples were grouped according to the polymorphic genotypes and the presence of H. pylori infection, an influence of TLR9-1237 TC + CC polymorphic genotypes (P = 0.0083) and H. pylori infection (P < 0.0001) was observed on the upregulation of mRNA expression.CONCLUSIONOur findings show that TLR9 rs5743836 and rs187084 polymorphisms are associated with a higher risk of carcinogenesis gastric, and that TLR9 mRNA levels can be modulated by TLR9-1237 TC + CC variant genotypes and H. pylori infection.

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Gene Polymorphisms of Toll-Like Receptor 9 −1486T/C and 2848G/A in Cervical Cancer Risk

Abstract: This meta-analysis indicates that TLR9 (-1486T/C, rs187084)-but not TLR9 (2848G/A, rs352140)-may be a risk factor for cervical cancer.

Cited by 14 publications

References 17 publications

The Associations between Toll-Like Receptor 9 Gene Polymorphisms and Cervical Cancer Susceptibility

The Associations between Toll-Like Receptor 9 Gene Polymorphisms and Cervical Cancer Susceptibility

The association between HOTAIR polymorphisms and cancer susceptibility: an updated systemic review and meta-analysis

Toll-like receptor 9 polymorphisms and Helicobacter pylori influence gene expression and risk of gastric carcinogenesis in the Brazilian population.

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