Gene Polymorphisms of Tumor Necrosis Factor Alpha
and Antioxidant Enzymes in Bronchial Asthma

Despotović, Milena; Stoimenov, Tatjana Jevtović; Stanković, Ivana; Pavlović, D.; Sokolović, Dušan; Cvetković, Tatjana; Kocić, Gordana; Bašić, Jelena; Veljković, Andrej; Djordjević, B

doi:10.17219/acem/40454

Cited by 18 publications

(11 citation statements)

References 26 publications

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“…TNF-α is a proinflammatory cytokine that is mainly secreted by multinuclear giant cells, with a wide range of biological activities, including the regulation of host immune functions and the inflammatory reaction process [24]. that TNF-α participates in several key processes of tumor progression, including oncogene activation, DNA damage, and tumor metastasis [25].…”

Section: Discussionmentioning

confidence: 99%

Tumor Necrosis Factor Alpha (TNF-α) –308G/A Polymorphism and the Risk of Multiple Myeloma: A Meta-analysis of Pooled Data from 12 Case-control Studies

Li¹,

Ye²

2019

Tjh

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Tumor necrosis factor alpha (TNF-α) is an important cytokine involved in inflammation, immune response, and other biological processes. The association between polymorphism-308G/A in its promoter and the risk of multiple myeloma (MM) is not clear. Thus, we conducted a meta-analysis to clarify this question. Materials and Methods: Twelve eligible studies, which included 2204 MM cases and 3478 controls, were enrolled in our meta-analysis by searching the PubMed, China National Knowledge Infrastructure, Scopus, Web of Science, and Google Scholar databases up to December 2018. The effect of polymorphism-308G/A on MM risk was evaluated by calculating the pooled odds ratio (OR) and the 95% confidence interval (CI). Furthermore, the Q-test and I2 statistical analyses were used to estimate the degree of heterogeneity. Sensitivity analysis was conducted to test the robustness of the meta-analysis results. Publication bias was assessed by Egger's test and visual inspection of a funnel plot. Results: In the dominant model,-308G/A polymorphism was associated with reduced MM risk (OR=0.80, 95% CI: 0.65-0.97), and it also demonstrated a significant protective effect with a pooled OR of 0.82 (95% CI: 0.68-0.99) in the Caucasian subgroup. Because of the limited number of individual studies with AA genotype carriers, only eight studies were included in the recessive model, and no significant difference was observed. Moreover, the meta-analysis of the allele frequency demonstrated that the A allele has a protective effect against MM risk with a pooled OR of 0.83 (95% CI: 0.69-0.99). Sensitivity analysis suggested that the synthesized effect size was not influenced by any individual study. Moreover, the Egger's test statistical analysis suggested that publication bias was not obvious in the present analysis. Amaç: Tümör nekroz faktör alfa (TNF-α) enflamasyon, immün cevap ve diğer biyolojik süreçlerde rol alan önemli bir sitokindir. TNF-α-308G/A promotor bölge polimorfizmi ile multipl myelom (MM) riski arasındaki ilişki net değildir. Bu soruya cevap aramak amacıyla bir meta-analiz çalışması gerçekleştirdik. Gereç ve Yöntemler: Meta analize 2018 Aralık ayına kadar PubMed, China National Knowledge Infrastructure, Scopus, "Web of Science", ve "Google Scholar"da yayınlanmış olan 2204 MM hastası ve 3478 kontrol içeren 12 çalışma dahil edildi.-308G/A polimorfizminin MM üzerine olan etkisi birleştirilmiş odds oranı (OR) ve %95 güven aralığı (CI) ile değerlendirildi. Heterojenite derecesinin hesaplanması için Q-test ve I2 istatistiksel analizleri kullanıldı. Meta analiz sonuçlarının kuvvet testi için hassasiyet analizi kullanıldı. Yayın yanlılık değerlendirilmesi Egger testi ve huni grafiğinin görsel incelemesi ile yapıldı. Bulgular: Baskın modelde,-308G/A polimorfizmi azalmış MM riski ile ilişkili bulundu (OR=0,80, %95 CI: 0,65-0,97), ve bu polimorfizm varlığının anlamlı koruyucu etkisi beyaz ırkta 0,82 (%95 CI: 0,68-0,99) birleştirilmiş OR ile de gösterildi. AA genotip taşıyıcılarının bireysel çalışmalarda daha az sayıda bulunması nedeniy...

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Section: Discussionmentioning

confidence: 99%

Tumor Necrosis Factor Alpha (TNF-α) –308G/A Polymorphism and the Risk of Multiple Myeloma: A Meta-analysis of Pooled Data from 12 Case-control Studies

Li¹,

Ye²

2019

Tjh

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“…It has been reported that IL-10 can suppress macrophage activity by inhibiting the production of interferon gamma, IL-2, IL-12, and IL-18 and that the modulation of the inflammatory response is essential to preserve immune system balance [ 15 ]. Tumor necrosis factor α (TNF-α) is a multifunctional and pro-inflammatory cytokine that can respond to inflammation, infection, and injury by mast cells, macrophages, eosinophils, epithelial cells, and neutrophils in asthma pathogenesis [ 16 ]. However, few studies have systematically investigated the inflammatory cytokine levels in patients with asthma, AECOPD, and ACOS.…”

Section: Introductionmentioning

confidence: 99%

Plasma Inflammatory Cytokine IL-4, IL-8, IL-10, and TNF-α Levels Correlate with Pulmonary Function in Patients with Asthma-Chronic Obstructive Pulmonary Disease (COPD) Overlap Syndrome

Huang

Liu

et al. 2016

Med Sci Monit

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BackgroundThe aim of this study was to investigate the plasma inflammatory cytokine levels and their correlations with pulmonary function in patients with asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS).Material/MethodsBetween January 2013 and December 2014, a total of 96 patients with asthma, acute exacerbation of chronic obstructive pulmonary disease (AECOPD), or ACOS were enrolled, and 35 healthy people were included as a control group. Fasting plasma interleukin (IL)-4, IL-8, IL-10, and tumor necrosis factor alpha (TNF-α) levels were detected using enzyme-linked immunosorbent assay (ELISA). Correlations between the plasma inflammatory cytokine levels and forced expiratory volume in 1 second (FEV1), FEV1/predicted value ratio (FEV1%pred), and FEV1/forced vital capacity (FVC) were analyzed.ResultsIL-4 and IL-8 levels showed statistically significant differences among the 3 groups of patients (both P<0.001); IL-4 level was significantly lower, while IL-8 level was significantly higher in the AECOPD group and ACOS group than those in the asthma group (all P<0.05). IL-10 level and TNF-α level were significantly different among the 3 patient groups (both P<0.001). IL-10 level was significantly different between each of the 2 groups (all P<0.001). TNF-α level in the asthma group was higher than in the AECOPD group and ACOS group (both P<0.001). IL-4 and IL-10 were positively and IL-8 and TNF-α were negatively related with FEV1, FEV1%pred, and FEV1/FVC.ConclusionsPlasma levels of inflammatory cytokines IL-4, IL-8, IL-10, and TNF-α are related with severity of airway diseases and could be potential markers for the evaluation of asthma, COPD, and ACOS.

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“…Our results suggest that naringenin could markedly decrease the release of IL-8 and TNF-α, protecting cells from CSE-induced inflammatory reaction. IL-8 and TNF-α are essential inflammatory cytokines of pulmonary illnesses [ 52 , 53 ]. Clinical studies have demonstrated the correlation between pulmonary illnesses and the content of IL-8 and TNF-α [ 54 ], and strong correlations have been found between the number of sputum cells (macrophages and neutrophils) and proinflammatory cytokine levels (IL-8 and TNF-α) [ 55 ], suggesting that IL-8 and TNF-α are suitable for evaluating the inflammatory reaction in BEAS-2B cells.…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Naringenin in Cigarette Smoke-Induced Damage to the Lung Based on Bioinformatic Prediction and In Vitro Analysis

Chen

Xiao

et al. 2020

Molecules

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Naringenin is found mainly in citrus fruits, and is thought to be beneficial in the prevention and control of lung diseases. This study aims to investigate the mechanisms of naringenin against the damage in the lung caused by cigarette smoke. A system bioinformatic approach was proposed to predict the mechanisms of naringenin for protecting lung health. Then, we validated this prediction in BEAS-2B cells treated with cigarette smoke extract (CSE). System bioinformatic analysis indicated that naringenin exhibits protective effects on lung through the inhibition of inflammation and suppression of oxidative stress based on a multi-pathways network, mainly including oxidative stress pathway, Nrf2 pathway, Lung fibrosis pathway, IL-3 signaling pathway, and Aryl hydrocarbon receptor pathway. The in vitro results showed that naringenin significantly attenuated CSE-induced up-regulation of IL-8 and TNF-α. CSE stimulation increased the mRNA expressions of Nrf2, HO-1, and NQO1; the levels of total protein and nuclear protein of Nrf2; and the activity of SOD on days 2 and 4; but decreased these indexes on day 6. Naringenin can balance the antioxidant system by regulating Nrf2 and its downstream genes, preliminarily validating that Nrf2 pathway is involved in the protection offered by naringenin against cigarette smoke-induced damage to the lung. It suggests that dietary naringenin shows possible potential use in the management of lung health.

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Gene Polymorphisms of Tumor Necrosis Factor Alpha and Antioxidant Enzymes in Bronchial Asthma

Cited by 18 publications

References 26 publications

Tumor Necrosis Factor Alpha (TNF-α) –308G/A Polymorphism and the Risk of Multiple Myeloma: A Meta-analysis of Pooled Data from 12 Case-control Studies

Tumor Necrosis Factor Alpha (TNF-α) –308G/A Polymorphism and the Risk of Multiple Myeloma: A Meta-analysis of Pooled Data from 12 Case-control Studies

Plasma Inflammatory Cytokine IL-4, IL-8, IL-10, and TNF-α Levels Correlate with Pulmonary Function in Patients with Asthma-Chronic Obstructive Pulmonary Disease (COPD) Overlap Syndrome

Beneficial Effects of Naringenin in Cigarette Smoke-Induced Damage to the Lung Based on Bioinformatic Prediction and In Vitro Analysis

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