2023
DOI: 10.1101/2023.03.17.532606
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Gene recoding by synonymous mutations creates promiscuous intragenic transcription initiation in mycobacteria

Abstract: Each genome encodes some codons more frequently than their synonyms (codon usage bias), but codons are also arranged more frequently into specific pairs (codon pair bias). Recoding viral genomes and yeast or bacterial genes with non-optimal codon pairs has been shown to decrease gene expression. Gene expression is thus importantly regulated not only by the use of particular codons but by their proper juxtaposition. We therefore hypothesized that non-optimal codon pairing could likewise attenuate Mtb genes. We … Show more

Help me understand this report
View published versions

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 68 publications
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?