Gene Regulation by Hormone-like Signals in Dictyostelium

Schaap, Pauline; Peters, Dorien J.M.; Haribabu, Bodduluri; Dottin, Robert P.

doi:10.1016/b978-0-12-429350-2.50018-8

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“…Starved amoebae become responsive to cAMP, which binds to serpentine cAMP receptors (cARs). Cells surrounding cAMP producing cells respond by chemotaxis and secreting cAMP themselves, which results in the formation of a multicellular aggregate, and, finally, a fruiting body (consisting of a stalk and spores) (16,17). Extracellular folic acid and cAMP have been shown to evoke several heterotrimeric G-protein-dependent responses in vegetative and aggregative D. discoideum cells, respectively.…”

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confidence: 99%