Gene regulatory cascade of senescence-associated NAC transcription factors activated by ETHYLENE-INSENSITIVE2-mediated leaf senescence signalling in Arabidopsis

Kim, Hyo Jung; Hong, Sung Hwan; Kim, You Wang; Lee, Il Hwan; Jun, Ji Hyung; Phee, Bong-Kwan; Timilsina, Rupak; Jeong, Hana; Lee, Yeonmi; Hong, Byoung Seok; Nam, Hong Gil; Woo, Hye Ryun; Lim, Pyung Ok

doi:10.1093/jxb/eru112

Cited by 238 publications

(249 citation statements)

References 51 publications

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“…Furthermore, several NAC transcription factors shown to be regulated by ETHYLENE-INSENSITIVE2 and involved in senescence were up-regulated in both mutant lines ( Fig. 10A; Kim et al, 2014). Finally, seven membrane-bound NAC transcription factors (ANAC013, At13328700; ANAC014, At1g33060; ANAC016, At1g34180; ANAC042, At2g43000; ANAC053, At3g10500; ANAC069, At4g01550; and ANAC089, At5g22290) that are involved in mediating mitochondrial retrograde signaling ( Fig.…”

Section: Specific Regulation Of Gene Expression and The Mitochondrialmentioning

confidence: 90%

Decreasing Electron Flux through the Cytochrome and/or Alternative Respiratory Pathways Triggers Common and Distinct Cellular Responses Dependent on Growth Conditions

et al. 2014

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Diverse signaling pathways are activated by perturbation of mitochondrial function under different growth conditions. Mitochondria have emerged as an important organelle for sensing and coping with stress in addition to being the sites of important metabolic pathways. Here, responses to moderate light and drought stress were examined in different Arabidopsis (Arabidopsis thaliana) mutant plants lacking a functional alternative oxidase (alternative oxidase1a [aox1a]), those with reduced cytochrome electron transport chain capacity (T3/T7 bacteriophage-type RNA polymerase, mitochondrial, and plastidial [rpoTmp]), and double mutants impaired in both pathways (aox1a:rpoTmp). Under conditions considered optimal for growth, transcriptomes of aox1a and rpoTmp were distinct. Under adverse growth conditions, however, transcriptome changes in aox1a and rpoTmp displayed a highly significant overlap and were indicative of a common mitochondrial stress response and downregulation of photosynthesis. This suggests that the role of mitochondria to support photosynthesis is provided through either the alternative pathway or the cytochrome pathway, and when either pathway is inhibited, such as under environmental stress, a common, dramatic, and succinct mitochondrial signal is activated to alter energy metabolism in both organelles. aox1a:rpoTmp double mutants grown under optimal conditions showed dramatic reductions in biomass production compared with aox1a and rpoTmp and a transcriptome that was distinct from aox1a or rpoTmp. Transcript data indicating activation of mitochondrial biogenesis in aox1a:rpoTmp were supported by a proteomic analysis of over 200 proteins. Under optimal conditions, aox1a: rpoTmp plants seemed to switch on many of the typical mitochondrial stress regulators. Under adverse conditions, aox1a:rpoTmp turned off these responses and displayed a biotic stress response. Taken together, these results highlight the diverse signaling pathways activated by the perturbation of mitochondrial function under different growth conditions.

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Section: Specific Regulation Of Gene Expression and The Mitochondrialmentioning

confidence: 90%

Decreasing Electron Flux through the Cytochrome and/or Alternative Respiratory Pathways Triggers Common and Distinct Cellular Responses Dependent on Growth Conditions

et al. 2014

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“…Such a loop implies that the cascade of coherent feed-forward loops regulates the expression of ORE1 during senescence. We note that EIN3 also directly binds to the promoter of NAP, a major senescence-promoting NAC transcription factor and one of the 89 senescence-promoting genes 3 (Supplementary Data 1), and induces NAP transcription 49 , indicating that EIN3 activates the expression of both ORE1 and NAP.…”

Section: Discussionmentioning

confidence: 95%

Phytochrome-interacting transcription factors PIF4 and PIF5 induce leaf senescence in Arabidopsis

et al. 2014

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Plants initiate senescence to shed photosynthetically inefficient leaves. Light deprivation induces leaf senescence, which involves massive transcriptional reprogramming to dismantle cellular components and remobilize nutrients. In darkness, intermittent pulses of red light can inhibit senescence, likely via phytochromes. However, the precise molecular mechanisms transducing the signals from light perception to the inhibition of senescence remain elusive. Here, we show that in Arabidopsis, dark-induced senescence requires phytochrome-interacting transcription factors PIF4 and PIF5 (PIF4/PIF5). ELF3 and phytochrome B inhibit senescence by repressing PIF4/PIF5 at the transcriptional and post-translational levels, respectively. PIF4/PIF5 act in the signalling pathways of two senescence-promoting hormones, ethylene and abscisic acid, by directly activating expression of EIN3, ABI5 and EEL. In turn, PIF4, PIF5, EIN3, ABI5 and EEL directly activate the expression of the major senescence-promoting NAC transcription factor ORESARA1, thus forming multiple, coherent feed-forward loops. Our results reveal how classical light signalling connects to senescence in Arabidopsis.

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“…ABF3 is a bZIP master regulator of ABA signaling that controls ABRE-dependent gene expression (16), GBF3 is a bZIP factor that binds G-box motifs (25), and AFP3 interacts with the bZIP protein ABI5 to fine-tune the ABA response (24). NAP, an NAC TF associated with stress and senescence (26,27), controls the expression of ABSCISIC ALDEHYDE OXIDASE3 (AAO3), an enzyme that catalyzes the final steps of ABA synthesis (28), and thereby may contribute further to ABA accumulation (Fig. 6).…”

Section: Discussionmentioning

confidence: 99%

Abscisic acid signaling is controlled by a BRANCHED1/HD-ZIP I cascade in Arabidopsis axillary buds

González-Grandío

Pajoro

Franco-Zorrilla

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Shoot-branching patterns determine key aspects of plant life and are important targets for crop breeding. However, we are still largely ignorant of the genetic networks controlling locally the most important decision during branch development: whether the axillary bud, or branch primordium, grows out to give a lateral shoot or remains dormant. Here we show that, inside the buds, the TEOSINTE BRANCHED1, CYCLOIDEA, PCF (TCP) transcription factor BRANCHED1 (BRC1) binds to and positively regulates the transcription of three related Homeodomain leucine zipper protein (HD-ZIP)-encoding genes: HOMEOBOX PROTEIN 21 (HB21), HOMEOBOX PROTEIN 40 (HB40), and HOMEOBOX PROTEIN 53 (HB53). These three genes, together with BRC1, enhance 9-CIS-EPOXICAROTENOID DIOXIGENASE 3 (NCED3) expression, lead to abscisic acid accumulation, and trigger hormone response, thus causing suppression of bud development. This TCP/HD-ZIP genetic module seems to be conserved in dicot and monocotyledonous species to prevent branching under light-limiting conditions.

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Gene regulatory cascade of senescence-associated NAC transcription factors activated by ETHYLENE-INSENSITIVE2-mediated leaf senescence signalling in Arabidopsis

Abstract: SummaryThe EIN2-mediated senescence signalling pathway coordinates the expression of genes during leaf senescence via the gene regulatory network involving EIN3 and senescence-associated NAC TFs.

Cited by 238 publications

References 51 publications

Decreasing Electron Flux through the Cytochrome and/or Alternative Respiratory Pathways Triggers Common and Distinct Cellular Responses Dependent on Growth Conditions

Decreasing Electron Flux through the Cytochrome and/or Alternative Respiratory Pathways Triggers Common and Distinct Cellular Responses Dependent on Growth Conditions

Phytochrome-interacting transcription factors PIF4 and PIF5 induce leaf senescence in Arabidopsis

Abscisic acid signaling is controlled by a BRANCHED1/HD-ZIP I cascade in Arabidopsis axillary buds

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